Protein Alignment GABA-B-R1 and Gabbr2

DIOPT Version :10

• Sequence 1: NP_523569.3
• Gene: GABA-B-R1 / 34878
• FlyBaseID: FBgn0260446
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_001074610.1
• Gene: Gabbr2 / 242425
• MGIID: 2386030
• Length: 940
• Species: Mus musculus
• Alignment Length: 847
• Identity: 287/847 - (33%)
• Similarity: 456/847 - (53%)
• Gaps: 58/847 - (6%)

  Fly    13 LLCLIAS--PHLQGGVAGRP------DELHIGGIFPI---AGKGGWQGGQACMPAARLALDDVNK 66
            ||.|:.|  |...|...|.|      ..|.|.|:.|:   ..||..  |:..:||..||::.:..
Mouse    27 LLSLLLSLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSI--GRGVLPAVELAIEQIRN 89

  Fly    67 QPNLLPGFKLILHSNDSECEPGLGASVMYNLLYNKPQKLMLLAG-CSTVCTTVAEAAKMWNLIVL 130
            :..|.|.| |.|...|:||:...|....|:.:...|..||:..| |.:|.:.:||:.:.|||:.|
Mouse    90 ESLLRPYF-LDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQL 153

  Fly   131 CYGASSPALSDRKRFPTLFRTHPSATVHNPTRIKLMKKFGWSRVAILQQAEEVFISTVEDLENRC 195
            .:.|::|.|:|:|::|..|||.||....||..:||:|.|.|.||..|.|..:.|.....||....
Mouse   154 SFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVL 218

  Fly   196 MEAGVEIVTRQSFLSDPTDAVRNLRRQDARIIVGLFYVVAARRVLCEMYKQQLYGRAHVWFFIGW 260
            ....:||...:||.:||..:|:.|:..|.|||:|.|....|.:|.|..:::.::|..:.|...||
Mouse   219 YGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGW 283

  Fly   261 YEDNWYE-VNLKAEGITCTVEQMRIAAEGHLTTEALMWNQNNQTTISGMTAEEFRHRLNQALIEE 324
            ||..|:| |:::|....|....:..|.||::..:....:.....||||.|.:::....|......
Mouse   284 YEPAWWEQVHVEANSSRCLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNSKRSGV 348

  Fly   325 GYDINHDRYPEGYQEAPLAYDAVWSVALAFNKTMERL--TTGKKSLRDFTYTDKEIADEIYAAMN 387
            |....|     ||     |||.:|.:|....:.||.|  ::..:.::||.|||..:...|..|||
Mouse   349 GPSKFH-----GY-----AYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMN 403

  Fly   388 STQFLGVSGVVAFSSQGDRIALTQIEQMIDGKYEKLGYYDTQLDNLSWLN-TEQWIGGKVPQDRT 451
            .|.|.||:|.|.|.: |:|:...:..|..|.:..|:|.|:...|.|..:| |.::.|.:.|:|:|
Mouse   404 ETNFFGVTGQVVFRN-GERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKT 467

  Fly   452 IVTHVLRTVSLPLFVCMCTISSCGIFVAFALIIFNIWNKHRRVIQSSHPVCNTIMLFGVIICLIS 516
            |:...||.:||||:..:..::..|:.:|.|.:.|||.|:::::|:.|.|..|.:::.|.::...|
Mouse   468 IILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYAS 532

  Fly   517 VILLGIDGRFVSPEEYPKICQARAWLLSTGFTLAYGAMFSKVWRVHRFTTKAKTDPKKKVEPWKL 581
            :.|.|:||.|||.:.:..:|..|.|:|:.|:|.|:||||:|.||||......|. .||.::..||
Mouse   533 IFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKM-KKKIIKDQKL 596

  Fly   582 YTMVSGLLSIDLVILLSWQIFDPLQRYLETFPLE-DPVSTTDDIKIRPELEHCESQRNSMWLGLV 645
            ..:|.|:|.|||.||:.||..|||:|.:|.:.:| ||...  ||.|||.|||||:...::|||:|
Mouse   597 LVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGR--DISIRPLLEHCENTHMTIWLGIV 659

  Fly   646 YGFKGLILVFGLFLAYETRSIKVKQINDSRYVGMSIYNVVVLCLITAPVGMVIASQQDASFAFVA 710
            |.:|||:::||.|||:|||::.:..:|||:|:|||:|||.::|:|.|.|..:...|.:..|..||
Mouse   660 YAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVA 724

  Fly   711 LAVIFCCFLSMLLIFVPKVIEVIRHP--------------KDKAESKYNPD-SAISKEDEERYQK 760
            |.:|||..:::.|:||||:|.:..:|              :.|.:||.:.. :::::....|.:.
Mouse   725 LVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEG 789

  Fly   761 LVTENEELQRLITQKEEKIRVLRQRLVERGDAKGT--------ELNGATGVASAAVATTSQPASL 817
            |.:||..|:..||:.::.:..:..:|.:..: |.|        |||....:.:...:|....|.|
Mouse   790 LQSENHRLRMKITELDKDLEEVTMQLQDTPE-KTTYIKQNHYQELNDILSLGNFTESTDGGKAIL 853

  Fly   818 IN 819
            .|
Mouse   854 KN 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_523569.3	PBP1_GABAb_receptor	34..443	CDD:380589	133/416 (32%)
		7tmC_GABA-B-R1	463..734	CDD:320418	115/271 (42%)
		TM helix 1	463..488	CDD:320418	7/24 (29%)
		TM helix 2	500..521	CDD:320418	5/20 (25%)
		TM helix 3	537..561	CDD:320418	12/23 (52%)
		TM helix 4	581..601	CDD:320418	10/19 (53%)
		TM helix 5	638..664	CDD:320418	14/25 (56%)
		TM helix 6	673..696	CDD:320418	13/22 (59%)
		TM helix 7	703..728	CDD:320418	10/24 (42%)
Gabbr2	NP_001074610.1	PBP1_GABAb_receptor	57..459	CDD:380589	133/415 (32%)
		7tmC_GABA-B-R2	479..748	CDD:320421	115/271 (42%)
		TM helix 1	479..504	CDD:320421	7/24 (29%)
		TM helix 2	516..537	CDD:320421	5/20 (25%)
		TM helix 3	553..577	CDD:320421	12/23 (52%)
		TM helix 4	596..616	CDD:320421	10/19 (53%)
		TM helix 5	652..678	CDD:320421	14/25 (56%)
		TM helix 6	687..710	CDD:320421	13/22 (59%)
		TM helix 7	717..742	CDD:320421	10/24 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	762..789		4/26 (15%)
		GBR2_CC	778..816	CDD:465774	7/37 (19%)