DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R1 and Gabbr2

DIOPT Version :9

Sequence 1:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_001074610.1	Gene:	Gabbr2 / 242425	MGIID:	2386030	Length:	940	Species:	Mus musculus

Alignment Length:	847	Identity:	287/847 - (33%)
Similarity:	456/847 - (53%)	Gaps:	58/847 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLCLIAS--PHLQGGVAGRP------DELHIGGIFPI---AGKGGWQGGQACMPAARLALDDVNK 66
            ||.|:.|  |...|...|.|      ..|.|.|:.|:   ..||..  |:..:||..||::.:..
Mouse    27 LLSLLLSLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSI--GRGVLPAVELAIEQIRN 89

  Fly    67 QPNLLPGFKLILHSNDSECEPGLGASVMYNLLYNKPQKLMLLAG-CSTVCTTVAEAAKMWNLIVL 130
            :..|.|.| |.|...|:||:...|....|:.:...|..||:..| |.:|.:.:||:.:.|||:.|
Mouse    90 ESLLRPYF-LDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQL 153

  Fly   131 CYGASSPALSDRKRFPTLFRTHPSATVHNPTRIKLMKKFGWSRVAILQQAEEVFISTVEDLENRC 195
            .:.|::|.|:|:|::|..|||.||....||..:||:|.|.|.||..|.|..:.|.....||....
Mouse   154 SFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVL 218

  Fly   196 MEAGVEIVTRQSFLSDPTDAVRNLRRQDARIIVGLFYVVAARRVLCEMYKQQLYGRAHVWFFIGW 260
            ....:||...:||.:||..:|:.|:..|.|||:|.|....|.:|.|..:::.::|..:.|...||
Mouse   219 YGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGW 283

  Fly   261 YEDNWYE-VNLKAEGITCTVEQMRIAAEGHLTTEALMWNQNNQTTISGMTAEEFRHRLNQALIEE 324
            ||..|:| |:::|....|....:..|.||::..:....:.....||||.|.:::....|......
Mouse   284 YEPAWWEQVHVEANSSRCLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNSKRSGV 348

  Fly   325 GYDINHDRYPEGYQEAPLAYDAVWSVALAFNKTMERL--TTGKKSLRDFTYTDKEIADEIYAAMN 387
            |....|     ||     |||.:|.:|....:.||.|  ::..:.::||.|||..:...|..|||
Mouse   349 GPSKFH-----GY-----AYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMN 403

  Fly   388 STQFLGVSGVVAFSSQGDRIALTQIEQMIDGKYEKLGYYDTQLDNLSWLN-TEQWIGGKVPQDRT 451
            .|.|.||:|.|.|.: |:|:...:..|..|.:..|:|.|:...|.|..:| |.::.|.:.|:|:|
Mouse   404 ETNFFGVTGQVVFRN-GERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKT 467

  Fly   452 IVTHVLRTVSLPLFVCMCTISSCGIFVAFALIIFNIWNKHRRVIQSSHPVCNTIMLFGVIICLIS 516
            |:...||.:||||:..:..::..|:.:|.|.:.|||.|:::::|:.|.|..|.:::.|.::...|
Mouse   468 IILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYAS 532

  Fly   517 VILLGIDGRFVSPEEYPKICQARAWLLSTGFTLAYGAMFSKVWRVHRFTTKAKTDPKKKVEPWKL 581
            :.|.|:||.|||.:.:..:|..|.|:|:.|:|.|:||||:|.||||......|. .||.::..||
Mouse   533 IFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKM-KKKIIKDQKL 596

  Fly   582 YTMVSGLLSIDLVILLSWQIFDPLQRYLETFPLE-DPVSTTDDIKIRPELEHCESQRNSMWLGLV 645
            ..:|.|:|.|||.||:.||..|||:|.:|.:.:| ||...  ||.|||.|||||:...::|||:|
Mouse   597 LVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGR--DISIRPLLEHCENTHMTIWLGIV 659

  Fly   646 YGFKGLILVFGLFLAYETRSIKVKQINDSRYVGMSIYNVVVLCLITAPVGMVIASQQDASFAFVA 710
            |.:|||:::||.|||:|||::.:..:|||:|:|||:|||.::|:|.|.|..:...|.:..|..||
Mouse   660 YAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVA 724

  Fly   711 LAVIFCCFLSMLLIFVPKVIEVIRHP--------------KDKAESKYNPD-SAISKEDEERYQK 760
            |.:|||..:::.|:||||:|.:..:|              :.|.:||.:.. :::::....|.:.
Mouse   725 LVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEG 789

  Fly   761 LVTENEELQRLITQKEEKIRVLRQRLVERGDAKGT--------ELNGATGVASAAVATTSQPASL 817
            |.:||..|:..||:.::.:..:..:|.:..: |.|        |||....:.:...:|....|.|
Mouse   790 LQSENHRLRMKITELDKDLEEVTMQLQDTPE-KTTYIKQNHYQELNDILSLGNFTESTDGGKAIL 853

  Fly   818 IN 819
            .|
Mouse   854 KN 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361	131/409 (32%)
		ANF_receptor	52..415	CDD:279440	118/366 (32%)
		7tm_3	476..730	CDD:278433	111/254 (44%)
Gabbr2	NP_001074610.1	PBP1_GABAb_receptor	57..459	CDD:380589	133/415 (32%)
		7tmC_GABA-B-R2	479..748	CDD:320421	115/271 (42%)
		TM helix 1	479..504	CDD:320421	7/24 (29%)
		TM helix 2	516..537	CDD:320421	5/20 (25%)
		TM helix 3	553..577	CDD:320421	12/23 (52%)
		TM helix 4	596..616	CDD:320421	10/19 (53%)
		TM helix 5	652..678	CDD:320421	14/25 (56%)
		TM helix 6	687..710	CDD:320421	13/22 (59%)
		TM helix 7	717..742	CDD:320421	10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..789		4/26 (15%)
		GBR2_CC	778..816	CDD:375881	7/37 (19%)
		PRK03992	785..>863	CDD:179699	17/72 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49267
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820