DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABA-B-R1 and Gpr156

DIOPT Version :9

Sequence 1:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_700443.2	Gene:	Gpr156 / 239845	MGIID:	2653880	Length:	798	Species:	Mus musculus

Alignment Length:	414	Identity:	101/414 - (24%)
Similarity:	180/414 - (43%)	Gaps:	65/414 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 VSLPLFVCMCTISSCGIFVAFALIIFNIWNKHRRVIQSSHPVCNTIMLFGVIICLISVILLGI-- 522
            :|..|...|.|..|||:.:....:.|.|..:..|:::.|.|..|.:.|.|..:..||..|.||
Mouse    45 LSPALLGIMWTFLSCGLLLVLFFLAFTIRCRKNRIVKMSSPNLNVVTLLGSCLTYISAYLFGIQD 109

  Fly   523 --DGRFVSPEEYPKICQARAWLLSTGFTLAYGAMFSKVWRVHRFTTKAKTDPKKKVEPWKLYTMV 585
              :|..|.     .:.|.|..||..|.:|.:|.:..|.||:::..|:...|.:..::..:|..:|
Mouse   110 ALEGSSVE-----ALIQTRLSLLCIGTSLVFGPILGKSWRLYKVFTQRVPDKRVIIKDLQLLGLV 169

  Fly   586 SGLLSIDLVILLSWQIFDPLQRYLETFPLEDPVSTTDDIKIRPELEHCESQRNSMWLGLVYGFKG 650
            :.|:..|:::|::|.:.||:| .|:...:...|:..|..........|.|:.:.:|:.||.|.||
Mouse   170 AALVVADVILLVTWVLTDPIQ-CLQMLGVSMKVTGRDVSCSLTNTHFCASRYSDVWIALVLGCKG 233

  Fly   651 LILVFGLFLAYETRSIKVKQINDSRYVGMSIYNVVVLCLITAPVGMVIA----SQQDASFA---- 707
            |:|::|.:||..|..:....:|.|    ::|...|.|.|:||.:..|:.    |..:..|.
Mouse   234 LLLLYGAYLAGLTNHVSSPPVNQS----LTIMVGVNLLLLTAGLLFVVTRYLHSWPNLVFGLTSG 294

  Fly   708 --FVALAVIFCCFLSMLLIFVPKV---------IEVIRH-------PKDKAESKYNPDSAISKED 754
              ||....:.||      :|:|::         .:.:||       |......:::.|.:....|
Mouse   295 GIFVCTTTVNCC------VFIPQLKQWKAFEGENQTMRHMAKYFSTPSKSFHGQFDEDPSCHLRD 353

  Fly   755 EER-YQKLVTEN----EELQRLITQKEEKIRVLRQ----------RLVERGDAKGTELNGATGVA 804
            |:. .::|:||.    |.||..::..:||:..|..          .:.:...|:|..|   .|.:
Mouse   354 EKSCMERLLTEKNAVIESLQEQVSNAKEKLVKLMSAECTYDSPEWAVPDAASARGLAL---PGPS 415

  Fly   805 SAAVATTSQPASLINSSAHATPAA 828
            .....:.::..:....|.| .|||
Mouse   416 ECPAVSENESGAAARDSLH-VPAA 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361
		ANF_receptor	52..415	CDD:279440
		7tm_3	476..730	CDD:278433	70/276 (25%)
Gpr156	NP_700443.2	7tm_3	71..>141	CDD:278433	21/74 (28%)
		rad18	347..>538	CDD:273165	20/96 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..497
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..666
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..715
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810