DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABA-B-R1 and Shbg

DIOPT Version :9

Sequence 1:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_035497.1	Gene:	Shbg / 20415	MGIID:	98295	Length:	403	Species:	Mus musculus

Alignment Length:	233	Identity:	50/233 - (21%)
Similarity:	73/233 - (31%)	Gaps:	105/233 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSDGAVTFWI---FLLCL-----IASPHLQGGVAGRPDELHIGGI--------FPIA------- 42
            |..| ::..|:   .:|||     ..:.|.|     |...:.:||:        ||:.
Mouse   137 MNGD-SLLLWVDGKEMLCLRQISASLADHSQ-----RSMRIALGGLLLPTSKLRFPLVPALDGCI 195

  Fly    43 GKGGWQGGQA---CMPAARLALDDVNKQPNL--------------LP-------------GFKLI 77
            .:..|.|.||   ..|...|...||:.||.|              :|             ||||:
Mouse   196 RRDIWLGHQAQLSASPRTSLGNCDVDLQPGLFFPPGTHAEFSLQDIPQPHADPWTFSLELGFKLV 260

  Fly    78 -------------------LHSND------SECEPGLGASVMYNLLYNKPQKLMLLAGCSTVCTT 117
                               :|..:      ||.||    .|:..|....|.:|.|    ..|...
Mouse   261 DGSGQLLALGTGTNSSWLNIHLQNQSVVLSSEAEP----KVVLPLDVGLPLQLTL----DRVKVV 317

  Fly   118 VAEAAKMWNLIVLCYGASSPALSDRKRFPTLFR--THP 153
            :::..||   .||......||        :|:|  :||
Mouse   318 LSQGPKM---EVLSMSLLRPA--------SLWRLWSHP 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361	41/192 (21%)
		ANF_receptor	52..415	CDD:279440	34/159 (21%)
		7tm_3	476..730	CDD:278433
Shbg	NP_035497.1	Laminin_G_1	76..206	CDD:333802	16/74 (22%)
Shbg	NP_035497.1	LamG	225..369	CDD:389952	27/139 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3927
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900