DRSC/TRiP Functional Genomics Resources

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Protein Alignment GABA-B-R1 and gbb-1

DIOPT Version :9

Sequence 1:NP_001246033.1 Gene:GABA-B-R1 / 34878 FlyBaseID:FBgn0260446 Length:841 Species:Drosophila melanogaster
Sequence 2:NP_741740.3 Gene:gbb-1 / 189837 WormBaseID:WBGene00021528 Length:899 Species:Caenorhabditis elegans


Alignment Length:844 Identity:370/844 - (43%)
Similarity:508/844 - (60%) Gaps:72/844 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 WIFLLCLIASPHLQGGVAGRPDELHIGGIFPI-AGKGGWQGGQACMPAARLALDDVNKQPNLLPG 73
            |:.|...|.      ..:..|..|||||.||: :|.|||.||:||:||..:||.|||.:.::|||
 Worm     7 WLLLWGTIV------WASAEPVTLHIGGTFPMESGSGGWAGGEACLPAVEMALKDVNSRLDILPG 65

  Fly    74 FKLILHSNDSECEPGLGASVMYNLLYNKPQKLMLLAGCSTVCTTVAEAAKMWNLIVLCYGASSPA 138
            :.|.:.:::|:|:|||....:|:.||..|.|||||.|||.|.|.:||||.:|.|:||.||.||||
 Worm    66 YVLNMTNHNSQCQPGLAMQQLYDFLYKPPTKLMLLTGCSPVTTVIAEAAPVWKLVVLSYGGSSPA 130

  Fly   139 LSDRKRFPTLFRTHPSATVHNPTRIKLMKKFGWSRVAILQQAEEVFISTVEDLENRCMEAGVEIV 203
            ||:|.||||||||||||.:.|||||.:|:||.|.|..||...||||::|.:|||....:.|:: |
 Worm   131 LSNRNRFPTLFRTHPSANMQNPTRIHIMEKFKWKRFTILMSVEEVFVTTAKDLEAIARKKGIK-V 194

  Fly   204 TRQSFLSDPTDAVRNLRRQDARIIVGLFYVVAARRVLCEMYKQQLYGRAHVWFFIGWYEDNWYEV 268
            .||||..|||||::.|:|||||||||||||..||:|||:.|...||||.:||||||||.|.|| :
 Worm   195 DRQSFYGDPTDAMKTLQRQDARIIVGLFYVTEARKVLCQAYHHGLYGRRYVWFFIGWYADTWY-I 258

  Fly   269 NLKAEGITCTVEQMRIAAEGHLTTEALMWNQNNQTTISGMTAEEFRHRLNQALIEEGYDINHDRY 333
            ....|.:.||.|||..|||.|.|||::|.:::|...||.||..:|:.||.|...::..::.    
 Worm   259 PPPEEHLNCTAEQMTEAAEYHFTTESVMLSRDNIPAISEMTGMQFQQRLTQYFQKDTANVG---- 319

  Fly   334 PEGYQEAPLAYDAVWSVALAFNKTMERLTTGKKSLRDFTYTDKEIADEIYAAMNSTQFLGVSGVV 398
              |:.||||||||||::|||||.|...|.:..: |.:|||.:|.|||.::..:.:|.|.||||.|
 Worm   320 --GFPEAPLAYDAVWALALAFNCTRNNLPSHIR-LENFTYDNKVIADTLFQCVKNTSFRGVSGKV 381

  Fly   399 AFSSQGDRIALTQIEQMIDGKYEKLGYYDTQLDNLSWLNTEQWIGGK-VPQDRTIVTHVLRTVSL 462
            .||..|||||.||||||..|||:.:|||||...:|.|.|.|||:.|| .|.|.|::.....|||.
 Worm   382 MFSDSGDRIARTQIEQMQGGKYKIMGYYDTTSGDLEWYNKEQWLNGKGPPPDSTVIKKHAMTVSN 446

  Fly   463 PLFVCMCTISSCGIFVAFALIIFNIWNKHRRVIQSSHPVCNTIMLFGVIICLISVILLGI--DGR 525
            ..:......:..||.....:.:|...:..|.:|..|.|.||.|:|.|..:||.|:.|:|:  |..
 Worm   447 EFYYPTILFAVLGIAACVFIYLFTQKHHERLIIFQSQPECNNILLIGCSLCLFSLFLIGLPSDDI 511

  Fly   526 FVSPEEYPKICQARAWLLSTGFTLAYGAMFSKVWRVHRF--TTKAKTDPKKKVE----PW----- 579
            .:|...:|.:|.||..:|..|||.|||:||:|||.|||.  |...:...::|.|    ||     
 Worm   512 SISESLFPLLCHARVTILLFGFTFAYGSMFAKVWIVHRMGATENQQLASRQKDEEENTPWEGIRT 576

  Fly   580 --------------------------------------KLYTMVSGLLSIDLVILLSWQIFDPLQ 606
                                                  |.|.:|:.|.::|:.:...|.:.|||.
 Worm   577 LISTMVGRQALMRKSSGQAYGALLEKRNTVLNQPISSSKFYVIVAALTAVDVFVCFVWVLIDPLH 641

  Fly   607 RYLETFPLEDPVSTTDDIKIRPELEHCESQRNSMWLGLVYGFKGLILVFGLFLAYETRSIKVKQI 671
            ...:.|||..|..:.:|..|.|.|:.|:|.:..:|:|::.|||.|:||||.||:||||::|::.|
 Worm   642 LTEQKFPLFTPADSEEDEMIMPVLQQCQSNQQEVWIGIIMGFKCLLLVFGTFLSYETRNLKLRFI 706

  Fly   672 NDSRYVGMSIYNVVVLCLITAP-VGMVIASQQDASFAFVALAVIFCCFLSMLLIFVPKVIEVIRH 735
            ||||:||::||||.|:.|:||| |.::|..:.||:|||::|.|:.|.::|:.||:.||:..:|:.
 Worm   707 NDSRFVGLAIYNVAVMTLVTAPVVTLLIHGKVDANFAFISLTVLICTYISVGLIYGPKIRHIIKV 771

  Fly   736 PKDKAESKYNPD---SAISKEDEERYQKLVTENEELQRLITQKEEKIRVLRQRLVERGDAKGTE 796
            |....|.:.|.:   ..:||.|::||..|..|||.||..|.:||.||...::||.|......||
 Worm   772 PPSADEIQLNGNVGPGVMSKVDQKRYDMLKKENETLQIQIEEKERKIHECKERLEELTKNSETE 835

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GABA-B-R1NP_001246033.1 PBP1_GABAb_receptor 34..437 CDD:107361 218/403 (54%)
ANF_receptor 52..415 CDD:279440 194/362 (54%)
7tm_3 476..730 CDD:278433 109/305 (36%)
gbb-1NP_741740.3 PBP1_GABAb_receptor 25..414 CDD:107361 216/397 (54%)
7tmC_GABA-B-R1 447..770 CDD:320418 110/322 (34%)
TM helix 1 447..472 CDD:320418 3/24 (13%)
TM helix 2 484..505 CDD:320418 10/20 (50%)
TM helix 3 523..547 CDD:320418 14/23 (61%)
TM helix 4 616..636 CDD:320418 5/19 (26%)
TM helix 5 673..699 CDD:320418 14/25 (56%)
TM helix 6 708..731 CDD:320418 14/22 (64%)
TM helix 7 739..764 CDD:320418 11/24 (46%)
PRKG1_interact 793..>848 CDD:318172 19/43 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160167456
Domainoid 1 1.000 383 1.000 Domainoid score I433
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1132
Inparanoid 1 1.050 678 1.000 Inparanoid score I368
Isobase 1 0.950 - 0 Normalized mean entropy S3553
OMA 1 1.010 - - QHG49267
OrthoDB 1 1.010 - - D267884at33208
OrthoFinder 1 1.000 - - FOG0006100
OrthoInspector 1 1.000 - - oto20304
orthoMCL 1 0.900 - - OOG6_105862
Panther 1 1.100 - - LDO PTHR10519
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3034
SonicParanoid 1 1.000 - - X4397
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1615.890

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