Protein Alignment GABA-B-R1 and gbb-1

DIOPT Version :10

• Sequence 1: NP_523569.3
• Gene: GABA-B-R1 / 34878
• FlyBaseID: FBgn0260446
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_741740.3
• Gene: gbb-1 / 189837
• WormBaseID: WBGene00021528
• Length: 899
• Species: Caenorhabditis elegans
• Alignment Length: 844
• Identity: 370/844 - (43%)
• Similarity: 508/844 - (60%)
• Gaps: 72/844 - (8%)

  Fly    10 WIFLLCLIASPHLQGGVAGRPDELHIGGIFPI-AGKGGWQGGQACMPAARLALDDVNKQPNLLPG 73
            |:.|...|.      ..:..|..|||||.||: :|.|||.||:||:||..:||.|||.:.::|||
 Worm     7 WLLLWGTIV------WASAEPVTLHIGGTFPMESGSGGWAGGEACLPAVEMALKDVNSRLDILPG 65

  Fly    74 FKLILHSNDSECEPGLGASVMYNLLYNKPQKLMLLAGCSTVCTTVAEAAKMWNLIVLCYGASSPA 138
            :.|.:.:::|:|:|||....:|:.||..|.|||||.|||.|.|.:||||.:|.|:||.||.||||
 Worm    66 YVLNMTNHNSQCQPGLAMQQLYDFLYKPPTKLMLLTGCSPVTTVIAEAAPVWKLVVLSYGGSSPA 130

  Fly   139 LSDRKRFPTLFRTHPSATVHNPTRIKLMKKFGWSRVAILQQAEEVFISTVEDLENRCMEAGVEIV 203
            ||:|.||||||||||||.:.|||||.:|:||.|.|..||...||||::|.:|||....:.|:: |
 Worm   131 LSNRNRFPTLFRTHPSANMQNPTRIHIMEKFKWKRFTILMSVEEVFVTTAKDLEAIARKKGIK-V 194

  Fly   204 TRQSFLSDPTDAVRNLRRQDARIIVGLFYVVAARRVLCEMYKQQLYGRAHVWFFIGWYEDNWYEV 268
            .||||..|||||::.|:|||||||||||||..||:|||:.|...||||.:||||||||.|.|| :
 Worm   195 DRQSFYGDPTDAMKTLQRQDARIIVGLFYVTEARKVLCQAYHHGLYGRRYVWFFIGWYADTWY-I 258

  Fly   269 NLKAEGITCTVEQMRIAAEGHLTTEALMWNQNNQTTISGMTAEEFRHRLNQALIEEGYDINHDRY 333
            ....|.:.||.|||..|||.|.|||::|.:::|...||.||..:|:.||.|...::..::.
 Worm   259 PPPEEHLNCTAEQMTEAAEYHFTTESVMLSRDNIPAISEMTGMQFQQRLTQYFQKDTANVG---- 319

  Fly   334 PEGYQEAPLAYDAVWSVALAFNKTMERLTTGKKSLRDFTYTDKEIADEIYAAMNSTQFLGVSGVV 398
              |:.||||||||||::|||||.|...|.:..: |.:|||.:|.|||.::..:.:|.|.||||.|
 Worm   320 --GFPEAPLAYDAVWALALAFNCTRNNLPSHIR-LENFTYDNKVIADTLFQCVKNTSFRGVSGKV 381

  Fly   399 AFSSQGDRIALTQIEQMIDGKYEKLGYYDTQLDNLSWLNTEQWIGGK-VPQDRTIVTHVLRTVSL 462
            .||..|||||.||||||..|||:.:|||||...:|.|.|.|||:.|| .|.|.|::.....|||.
 Worm   382 MFSDSGDRIARTQIEQMQGGKYKIMGYYDTTSGDLEWYNKEQWLNGKGPPPDSTVIKKHAMTVSN 446

  Fly   463 PLFVCMCTISSCGIFVAFALIIFNIWNKHRRVIQSSHPVCNTIMLFGVIICLISVILLGI--DGR 525
            ..:......:..||.....:.:|...:..|.:|..|.|.||.|:|.|..:||.|:.|:|:  |..
 Worm   447 EFYYPTILFAVLGIAACVFIYLFTQKHHERLIIFQSQPECNNILLIGCSLCLFSLFLIGLPSDDI 511

  Fly   526 FVSPEEYPKICQARAWLLSTGFTLAYGAMFSKVWRVHRF--TTKAKTDPKKKVE----PW----- 579
            .:|...:|.:|.||..:|..|||.|||:||:|||.|||.  |...:...::|.|    ||
 Worm   512 SISESLFPLLCHARVTILLFGFTFAYGSMFAKVWIVHRMGATENQQLASRQKDEEENTPWEGIRT 576

  Fly   580 --------------------------------------KLYTMVSGLLSIDLVILLSWQIFDPLQ 606
                                                  |.|.:|:.|.::|:.:...|.:.|||.
 Worm   577 LISTMVGRQALMRKSSGQAYGALLEKRNTVLNQPISSSKFYVIVAALTAVDVFVCFVWVLIDPLH 641

  Fly   607 RYLETFPLEDPVSTTDDIKIRPELEHCESQRNSMWLGLVYGFKGLILVFGLFLAYETRSIKVKQI 671
            ...:.|||..|..:.:|..|.|.|:.|:|.:..:|:|::.|||.|:||||.||:||||::|::.|
 Worm   642 LTEQKFPLFTPADSEEDEMIMPVLQQCQSNQQEVWIGIIMGFKCLLLVFGTFLSYETRNLKLRFI 706

  Fly   672 NDSRYVGMSIYNVVVLCLITAP-VGMVIASQQDASFAFVALAVIFCCFLSMLLIFVPKVIEVIRH 735
            ||||:||::||||.|:.|:||| |.::|..:.||:|||::|.|:.|.::|:.||:.||:..:|:.
 Worm   707 NDSRFVGLAIYNVAVMTLVTAPVVTLLIHGKVDANFAFISLTVLICTYISVGLIYGPKIRHIIKV 771

  Fly   736 PKDKAESKYNPD---SAISKEDEERYQKLVTENEELQRLITQKEEKIRVLRQRLVERGDAKGTE 796
            |....|.:.|.:   ..:||.|::||..|..|||.||..|.:||.||...::||.|......||
 Worm   772 PPSADEIQLNGNVGPGVMSKVDQKRYDMLKKENETLQIQIEEKERKIHECKERLEELTKNSETE 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_523569.3	PBP1_GABAb_receptor	34..443	CDD:380589	222/409 (54%)
		7tmC_GABA-B-R1	463..734	CDD:320418	110/322 (34%)
		TM helix 1	463..488	CDD:320418	3/24 (13%)
		TM helix 2	500..521	CDD:320418	10/20 (50%)
		TM helix 3	537..561	CDD:320418	14/23 (61%)
		TM helix 4	581..601	CDD:320418	5/19 (26%)
		TM helix 5	638..664	CDD:320418	14/25 (56%)
		TM helix 6	673..696	CDD:320418	15/23 (65%)
		TM helix 7	703..728	CDD:320418	11/24 (46%)
gbb-1	NP_741740.3	PBP1_GABAb_receptor	25..426	CDD:380589	222/409 (54%)
		7tmC_GABA-B-R1	447..770	CDD:320418	110/322 (34%)
		TM helix 1	447..472	CDD:320418	3/24 (13%)
		TM helix 2	484..505	CDD:320418	10/20 (50%)
		TM helix 3	523..547	CDD:320418	14/23 (61%)
		TM helix 4	616..636	CDD:320418	5/19 (26%)
		TM helix 5	673..699	CDD:320418	14/25 (56%)
		TM helix 6	708..731	CDD:320418	14/22 (64%)
		TM helix 7	739..764	CDD:320418	11/24 (46%)