DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABA-B-R1 and nkb-2

DIOPT Version :9

Sequence 1:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_501958.1	Gene:	nkb-2 / 177950	WormBaseID:	WBGene00008074	Length:	374	Species:	Caenorhabditis elegans

Alignment Length:	187	Identity:	42/187 - (22%)
Similarity:	62/187 - (33%)	Gaps:	57/187 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSDGAVTF---WIFLLCLIASPHLQGGVAGRPDELHIGGIFPIAGKGGWQGGQACMPAARLALD 62
            ||.:.|..|   ..|..|.::..:|:.|.                   |:..||.|:   .|.|:
Worm   214 MTRENACKFDRLTDFGECTLSLDNLERGF-------------------GYSKGQPCI---MLKLN 256

  Fly    63 D-VNKQPNLLPG-FKLILHSNDSECEPGL------GASVMYNLL-----------------YNKP 102
            . |...|||.|. .|....|.|..|..|:      .|.|.:...                 |.:|
Worm   257 KIVGWVPNLSPSKNKTKCPSGDLCCGQGIKFKCTSNADVKFEYFPKTGIPTCYFPYANQGGYEQP 321

  Fly   103 QKLMLLAGCSTVCTTVAEAA-KMWNLIVLCYGASSPALSDRKRFPTLF-RTHPSATV 157
            .:::.|...:....|..|.| :..:|..|..|.::.|     ||..|. :..|..||
Worm   322 YQMVKLTNITVNRETTIECAPEDSSLNTLASGKTNEA-----RFHILMTKNRPVETV 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361	34/151 (23%)
		ANF_receptor	52..415	CDD:279440	31/133 (23%)
		7tm_3	476..730	CDD:278433
nkb-2	NP_501958.1	Na_K-ATPase	102..340	CDD:298651	30/147 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3927
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900