DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R1 and GPR156

DIOPT Version :9

Sequence 1:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_694547.2	Gene:	GPR156 / 165829	HGNCID:	20844	Length:	814	Species:	Homo sapiens

Alignment Length:	423	Identity:	100/423 - (23%)
Similarity:	187/423 - (44%)	Gaps:	56/423 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   450 RTIVT---HVLRTVS--LPLFV-CMCTISSCGIFVAFALIIFNIWNKHRRVIQSSHPVCNTIMLF 508
            :|.:|   |..:|:|  .|:.: .:.|..|||:.:....:.|.|..:..|:::.|.|..|.:.|.
Human    29 KTTITSSHHSSKTISSLSPVLLGIVWTFLSCGLLLILFFLAFTIHCRKNRIVKMSSPNLNIVTLL 93

  Fly   509 GVIICLISVILLGIDGRFVSPEEYPKICQARAWLLSTGFTLAYGAMFSKVWRVHRFTTKAKTDPK 573
            |..:...|..|.||....|. .....:.|.|..:|..|.:|.:|.:..|.||:::..|:...|.:
Human    94 GSCLTYSSAYLFGIQDVLVG-SSMETLIQTRLSMLCIGTSLVFGPILGKSWRLYKVFTQRVPDKR 157

  Fly   574 KKVEPWKLYTMVSGLLSIDLVILLSWQIFDPLQRYLETFPLEDPVSTTDDIKIRPELEH-CESQR 637
            ..::..:|..:|:.||..|:::|::|.:.||:| .|:...:...| |..|:.......| |.|:.
Human   158 VIIKDLQLLGLVAALLMADVILLMTWVLTDPIQ-CLQILSVSMTV-TGKDVSCTSTSTHFCASRY 220

  Fly   638 NSMWLGLVYGFKGLILVFGLFLAYETRSIKVKQINDSRYVGMSIYNVVVLCLITAPVGMVIASQQ 702
            :.:|:.|::|.|||:|::|.:||..|..:....:|.|..:.:.:..:|:...:...|...:.|..
Human   221 SDVWIALIWGCKGLLLLYGAYLAGLTGHVSSPPVNQSLTIMVGVNLLVLAAGLLFVVTRYLHSWP 285

  Fly   703 DASFAFVALAVIFCCFLSMLLIFVPKV---------IEVIRH-------PKDKAESKYNPDSAIS 751
            :..|...:..:..|.......||:|::         .:.||.       |.....::|.
Human   286 NLVFGLTSGGIFVCTTTINCFIFIPQLKQWKAFEEENQTIRRMAKYFSTPNKSFHTQYG------ 344

  Fly   752 KEDEERYQKLVTENEELQRLITQK-------EEKIRVLRQRLVERGDAKGT-EL-NGATGVASAA 807
             |:|..:.:  .|...::||:|:|       :|::...::::|....|:.| :| .||
Human   345 -EEENCHPR--GEKSSMERLLTEKNAVIESLQEQVNNAKEKIVRLMSAECTYDLPEGA------- 399

  Fly   808 VATTSQPASLINSSAHATPAA-TLAITQDTHEH 839
                :.|||..|....|..:. |||..|....|
Human   400 ----APPASSPNKDVQAVASVHTLAAAQGPSGH 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361
		ANF_receptor	52..415	CDD:279440
		7tm_3	476..730	CDD:278433	62/263 (24%)
GPR156	NP_694547.2	7tm_3	71..312	CDD:278433	61/243 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..545		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	557..724
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	769..792
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810