Protein Alignment GABA-B-R1 and GABA-B-R1

DIOPT Version :10

• Sequence 1: NP_523569.3
• Gene: GABA-B-R1 / 34878
• FlyBaseID: FBgn0260446
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: XP_061511483.1
• Gene: GABA-B-R1 / 1279704
• VectorBaseID: AGAMI1_011219
• Length: 840
• Species: Anopheles gambiae
• Alignment Length: 846
• Identity: 677/846 - (80%)
• Similarity: 743/846 - (87%)
• Gaps: 38/846 - (4%)

  Fly     2 TSDGAVT-FW--------IFLLCLIASPHLQGGVAGRPDELHIGGIFPIAGKGGWQGGQACMPAA 57
            |:|.:|. ||        |.|:..|:|      |.| .::|||||||||||||||||||||||||
Mosquito    15 TTDNSVEYFWKNSSVFYLIILILFISS------VNG-ANQLHIGGIFPIAGKGGWQGGQACMPAA 72

  Fly    58 RLALDDVNKQPNLLPGFKLILHSNDSECEPGLGASVMYNLLYNKPQKLMLLAGCSTVCTTVAEAA 122
            :|||.|||:.|:|||||.|.|||||||||||||||||||||||.|||||||||||||||||||||
Mosquito    73 KLALQDVNENPDLLPGFNLTLHSNDSECEPGLGASVMYNLLYNSPQKLMLLAGCSTVCTTVAEAA 137

  Fly   123 KMWNLIVLCYGASSPALSDRKRFPTLFRTHPSATVHNPTRIKLMKKFGWSRVAILQQAEEVFIST 187
            |||||:||||||||||||||.|||||||||||||||||||||||:||||||||||||||||||||
Mosquito   138 KMWNLVVLCYGASSPALSDRSRFPTLFRTHPSATVHNPTRIKLMQKFGWSRVAILQQAEEVFIST 202

  Fly   188 VEDLENRCMEAGVEIVTRQSFLSDPTDAVRNLRRQDARIIVGLFYVVAARRVLCEMYKQQLYGRA 252
            |||||.||.:||:||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   203 VEDLETRCKDAGIEIVTRQSFLSDPTDAVRNLRRQDARIIVGLFYVVAARRVLCEMYKQQLYGRA 267

  Fly   253 HVWFFIGWYEDNWYEVNLKAEGITCTVEQMRIAAEGHLTTEALMWNQNNQTTISGMTAEEFRHRL 317
            :||||||||||||||||||.|.|:||.|||:|||||||||||||||||||.|||||::|:||.||
Mosquito   268 YVWFFIGWYEDNWYEVNLKNENISCTKEQMKIAAEGHLTTEALMWNQNNQKTISGMSSEDFRKRL 332

  Fly   318 NQALIEEGYDINHDRYPEGYQEAPLAYDAVWSVALAFNKTMERLT--TGKKSLRDFTYTDKEIAD 380
            |.|||||||||||:|||||||||||||||||||||||||||:|||  ...|:|:||||||||||:
Mosquito   333 NAALIEEGYDINHNRYPEGYQEAPLAYDAVWSVALAFNKTMQRLTEQNSGKNLKDFTYTDKEIAN 397

  Fly   381 EIYAAMNSTQFLGVSGVVAFSSQGDRIALTQIEQMIDGKYEKLGYYDTQLDNLSWLNTEQWIGGK 445
            .|||||||||||||||||||||||||||||||||||||:|.||||||||.|||:|.:.|:|.|.|
Mosquito   398 AIYAAMNSTQFLGVSGVVAFSSQGDRIALTQIEQMIDGQYYKLGYYDTQADNLTWFDKEKWDGEK 462

  Fly   446 VPQDRTIVTHVLRTVSLPLFVCMCTISSCGIFVAFALIIFNIWNKHRRVIQSSHPVCNTIMLFGV 510
            ||||||||..||||||||||:||.||||.||.||..||:||||::||||||||||||||||||||
Mosquito   463 VPQDRTIVRRVLRTVSLPLFICMSTISSFGILVAVTLIVFNIWHRHRRVIQSSHPVCNTIMLFGV 527

  Fly   511 IICLISVILLGIDGRFVSPEEYPKICQARAWLLSTGFTLAYGAMFSKVWRVHRFTTKAKTDPKKK 575
            ||||:|||||||||:|::.|.|||:||||||:|||||||||||||||||||||||||.|||||||
Mosquito   528 IICLVSVILLGIDGQFITAENYPKVCQARAWILSTGFTLAYGAMFSKVWRVHRFTTKTKTDPKKK 592

  Fly   576 VEPWKLYTMVSGLLSIDLVILLSWQIFDPLQRYLETFPLEDPVSTTDDIKIRPELEHCESQRNSM 640
            ||||||||||||||::||||||:||:.|||||.|||||||||:|:.||:|||||||||||..||:
Mosquito   593 VEPWKLYTMVSGLLAVDLVILLTWQMQDPLQRRLETFPLEDPISSNDDVKIRPELEHCESHNNSV 657

  Fly   641 WLGLVYGFKGLILVFGLFLAYETRSIKVKQINDSRYVGMSIYNVVVLCLITAPVGMVIASQQDAS 705
            |||::|||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||
Mosquito   658 WLGVIYGFKGLILVFGLFLAYETRSIKVKQINDSRYVGMSIYNVVVLCLITAPVAMVIASQQDAS 722

  Fly   706 FAFVALAVIFCCFLSMLLIFVPKVIEVIRHPKDKAESKYNPDSAISKEDEERYQKLVTENEELQR 770
            |||||||||||||||||||||||||||:||||||.|||::.|:.||||||||||||::||::||:
Mosquito   723 FAFVALAVIFCCFLSMLLIFVPKVIEVLRHPKDKVESKFSNDTGISKEDEERYQKLISENDDLQK 787

  Fly   771 LITQKEEKIRVLRQRLVERGDAKGTELNGATGVASAAVATTSQPASLINSSAHATPAATLAITQD 835
            ||.|||:|||:|:|||.||.:                 ..|:||   .|.||:.|.|..:...:.
Mosquito   788 LIAQKEDKIRLLKQRLTEREN-----------------KNTAQP---FNESANGTTAGGMQFNRS 832

  Fly   836 T 836
            :
Mosquito   833 S 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_523569.3	PBP1_GABAb_receptor	34..443	CDD:380589	364/410 (89%)
		7tmC_GABA-B-R1	463..734	CDD:320418	236/270 (87%)
		TM helix 1	463..488	CDD:320418	17/24 (71%)
		TM helix 2	500..521	CDD:320418	19/20 (95%)
		TM helix 3	537..561	CDD:320418	22/23 (96%)
		TM helix 4	581..601	CDD:320418	16/19 (84%)
		TM helix 5	638..664	CDD:320418	22/25 (88%)
		TM helix 6	673..696	CDD:320418	22/22 (100%)
		TM helix 7	703..728	CDD:320418	24/24 (100%)
GABA-B-R1	XP_061511483.1	None