DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABA-B-R1 and gpr156

DIOPT Version :9

Sequence 1:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_005167483.1	Gene:	gpr156 / 101885196	ZFINID:	ZDB-GENE-060201-2	Length:	800	Species:	Danio rerio

Alignment Length:	409	Identity:	99/409 - (24%)
Similarity:	189/409 - (46%)	Gaps:	46/409 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 RTVSLPLFVCMCTISSCGIFVAFALIIFNIWNKHRRVIQSSHPVCNTIMLFGVIICLISVILLGI 522
            |::|..|...:.|:.||||.:|...:||.:..|:.|:::.|.|..|.:.|.|.::...|..|..|
Zfish    47 RSLSPALRAVVWTLLSCGILLALFFLIFTLRFKNNRIVKMSSPNLNVLTLCGSVLTYSSGFLFAI 111

  Fly   523 DGR-FVSPEEYPKICQARAWLLSTGFTLAYGAMFSKVWRVHRFTTKAKTDPKKKVEPWKLYTMVS 586
            :.: .:|......:.|||.|.|..|.:|.:|.:..|.||::|..|:...|.:..:...:|..:|:
Zfish   112 EEKSLLSGAGARAVLQARMWTLCIGSSLVFGPILGKTWRLYRVFTQRVPDKRVIIRDIQLMGLVA 176

  Fly   587 GLLSIDLVILLSWQIFDP------LQRYLETFPLEDPVSTTDDIKIRPELEHCESQRNSMWLGLV 645
            .|:.:|:|:|.:|.:.||      :...::...|:...|.:       :|:.|.|..:.:|:.|:
Zfish   177 LLVLVDIVVLTAWGLMDPAKCSRSVSAMVKVIDLDSSYSLS-------QLDSCSSLYSHLWIILI 234

  Fly   646 YGFKGLILVFGLFLAYETRSIKVKQINDSRYVGMSIYNVVVLCLITAPVGMVIASQQDASFAFVA 710
            ...||.:|::|.:||..|.::.:..:|.|:.:..::..|.:...:..|:.:.:.|..:..::.::
Zfish   235 SVLKGSLLLYGTYLAGLTSNVSLPPVNQSKTIMGAVCLVTMSSAVAVPISLYLYSWPNVVYSVIS 299

  Fly   711 LAVIFCCFLSMLLIFVPKVI-------EVIRHPKDKAESKYNPD---SAISKEDEERYQKLVTEN 765
            .|:..|......|:|||::.       |...||...|:...:|.   :::..|||..|  |:.||
Zfish   300 GAIFICTMAINCLLFVPQLTQWRHFEEETNSHPSQMAKYFSSPSKTTNSMYSEDEIYY--LLGEN 362

  Fly   766 EELQRLITQKEE-----------------KIRVLRQRLVERG-DAKGTELNGATGVASAAVATTS 812
            :.::|||.:|..                 |:....|.|.||. |:..|.||..:  ....|.:..
Zfish   363 DSMKRLINEKNAVIDSLQEQVNNAKDKLLKLMTASQLLDEREMDSSNTNLNSTS--TQTTVVSPD 425

  Fly   813 QPASLINSSAHATPAATLA 831
            .|..::...:...|...|:
Zfish   426 SPTLVLKQYSEVAPTRVLS 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361
		ANF_receptor	52..415	CDD:279440
		7tm_3	476..730	CDD:278433	63/260 (24%)
gpr156	XP_005167483.1	7tm_3	65..318	CDD:278433	63/259 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810