Protein Alignment GABA-B-R1 and gpr156

DIOPT Version :10

• Sequence 1: NP_523569.3
• Gene: GABA-B-R1 / 34878
• FlyBaseID: FBgn0260446
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: XP_004919836.1
• Gene: gpr156 / 101730302
• XenbaseID: XB-GENE-962217
• Length: 792
• Species: Xenopus tropicalis
• Alignment Length: 457
• Identity: 113/457 - (24%)
• Similarity: 197/457 - (43%)
• Gaps: 93/457 - (20%)

  Fly   429 QLDNLSWLNTEQWIGGKVPQDRTIVTHVLRTVSLPLFVCMCTISSCGIFVAFALIIFNIWNKHRR 493
            :|..:||          .||.:.:...||....        .:.|.|:.:.....||.:..:..|
 Frog    30 ELCKVSW----------APQRKQVSAAVLGISG--------ALLSAGLLLTLFFFIFTLRFRSNR 76

  Fly   494 VIQSSHPVCNTIMLFGVIICLISVILLGIDGRFVSPEEYPKICQARAWLLSTGFTLAYGAMFSKV 558
            :::.|.|..|.:.|.|..:..||..|..:....:|.|   .|.|.|..||..|.||.:|.:..|.
 Frog    77 IVKMSSPNLNLVTLIGSALTYISAFLFVVQEPNISME---TIFQVRISLLYLGVTLVFGPLLGKS 138

  Fly   559 WRVHRFTTKAKTDPKKKVEPWKLYTMVSGLLSIDLVILLSWQIFDPLQRYLETFPLEDPV----S 619
            ||:||..|....|.:..::...|.::|:|||..|.::||.|             .|.|||    |
 Frog   139 WRLHRVFTHRVPDKRVIIKDVTLLSLVAGLLFADTLLLLMW-------------VLSDPVVCARS 190

  Fly   620 TTDDIK--IRPEL------EHCESQRNSMWLGLVYGFKGLILVFGLFLAYETRSIKVKQINDSRY 676
            .:..||  .|..|      :.|.|:.:.:|.||:.|||..:|::|.:||..|.:|....:|.|
 Frog   191 ASASIKAAARGTLYSVTTQDFCASKYSDLWTGLLVGFKAALLIYGGYLAGLTNNISSPPVNQS-- 253

  Fly   677 VGMSIYNVVVLCLITAPVGMVIASQQDAS---FAFVALAVIFCCFLSMLLIFVPKVIEVIRHPKD 738
            :.:.|.|.:|:. .|..|.:|.....|.|   :|..:.:::.|......|||:|::::..:..::
 Frog   254 LAIMIGNGLVMA-GTGAVFLVTHFFHDWSNLVYATTSGSILVCTTAINCLIFIPQLLQSRQFEEE 317

  Fly   739 KAE----SKY--NPDSAI-SKEDEERYQKLVTENEELQRLITQKEEKIRVLRQRLVERGDAKG-- 794
            :.:    |||  :|..:. |...||:...|:.||..:::|:::|...|..|::::   .:||.
 Frog   318 QVQSTQMSKYFSSPSKSFRSMYSEEQIYHLLGENTSMRKLLSEKNAIIESLQEQV---SNAKEKL 379

  Fly   795 ------------------TELNGAT-----GVASAAVATTSQPASLINSSAHATPAATLAITQDT 836
                              :.|:.:|     .||...:.|..:|...:.::.|.      |:.:||
 Frog   380 MKLIKSECSFETIEVTSLSVLSASTLAIQHHVAPEHMKTIEEPLDSVENADHE------AVIKDT 438

  Fly   837 HE 838
            .|
 Frog   439 QE 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_523569.3	PBP1_GABAb_receptor	34..443	CDD:380589	3/13 (23%)
		7tmC_GABA-B-R1	463..734	CDD:320418	79/285 (28%)
		TM helix 1	463..488	CDD:320418	4/24 (17%)
		TM helix 2	500..521	CDD:320418	7/20 (35%)
		TM helix 3	537..561	CDD:320418	10/23 (43%)
		TM helix 4	581..601	CDD:320418	9/19 (47%)
		TM helix 5	638..664	CDD:320418	10/25 (40%)
		TM helix 6	673..696	CDD:320418	6/22 (27%)
		TM helix 7	703..728	CDD:320418	7/27 (26%)
gpr156	XP_004919836.1	7tmC_GPR156	71..313	CDD:320419	75/260 (29%)
		TM helix 2	83..104	CDD:320419	7/20 (35%)
		TM helix 3	117..141	CDD:320419	10/23 (43%)
		TM helix 4	161..181	CDD:320419	9/32 (28%)
		TM helix 5	217..243	CDD:320419	10/25 (40%)
		TM helix 6	252..275	CDD:320419	7/25 (28%)
		TM helix 7	282..307	CDD:320419	5/24 (21%)