DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R1 and LOC100498444

DIOPT Version :9

Sequence 1:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_031751053.1	Gene:	LOC100498444 / 100498444	-ID:	-	Length:	1008	Species:	Xenopus tropicalis

Alignment Length:	844	Identity:	153/844 - (18%)
Similarity:	282/844 - (33%)	Gaps:	238/844 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 ALDDVNKQPNLLPGFKLILHSNDSECE-------------PGLGASVMYNLLYNKPQKLMLLAG- 110
            |:|::|:.|.:||...|..|..|| |.             .|.|.:|. |....:..::....|
Frog    77 AVDEINRNPAILPNVTLGYHIFDS-CRNVNNAMQDVFSILSGPGETVP-NYSCREQHRVAGFIGD 139

  Fly   111 -CSTVCTTVAEAAKMWNLIVLCYGASSPALSDRKRFPTLFRTHPSATVHNPTRIKLMKKFGWSRV 174
             .:.....:|:..:.:....:.|||:...|||::.:|..|||.|:.........||::..||:.|
Frog   140 LFTETSLPIAQLLRPYGYSQISYGATDHLLSDKRFYPAFFRTLPNDQTQYQAIAKLLRHLGWNWV 204

  Fly   175 AILQQAEEVFISTVEDLENRCMEAGVEIVTRQSFLSDPTDAVRNLRRQD--ARIIVGLFYVVAAR 237
            .|::..:::......||.....|.|:.|   :..||.|.:  :|.||.:  ||:...|....:..
Frog   205 GIIRSDDDIGEQLSRDLSKVLGEYGICI---EYTLSIPEE--QNPRRDELYARLQGKLRQTTSRG 264

  Fly   238 RVLCEMYKQQLYGRAHVWFFIGWYED-------------NWYEVNLKAEGITCTVEQMRIAAEGH 289
            .|:|        .|..:::......:             ||   |.:...   |...:|....|.
Frog   265 AVMC--------SRVSLFYMNSLTREEGSLLEKILIVPVNW---NYRPYS---TARSLRTLYNGT 315

  Fly   290 L----------TTEALMWNQNN-----------QTTISGMTAEEFRHRLNQALIEEGYDINHDRY 333
            |          ....|:.|.|.           .|..:.:|:...|:.:.|.:           |
Frog   316 LFFKRPSKNLPRLHRLLENLNRTKGDKMLEDIFATYFNCLTSVPLRNTMIQTI-----------Y 369

  Fly   334 P-----------------EGYQEAPL-----AYDAVWSVALAFNKTM-----ERLTTG----KKS 367
            |                 :||.....     .|.||:::|.|.:..:     ..|.||    ::.
Frog   370 PLVLGNCSGKEKITQLKRKGYNTVTFRTTYHVYKAVYAMAYALHHMLLPRGPPHLHTGAHIHRER 434

  Fly   368 LRDF---TYTDKEIADEIYAAMNS---------TQFLGVSGVVAFSSQGD-RIALTQIEQMI--- 416
            .|.|   .:......:|||...|.         .|...|:|.......|. ..:..:.||:|
Frog   435 FRHFLTKVHFKDPTGEEIYFKENGEMSSVYHLLQQINWVNGTTELRHVGTFNSSAPEEEQLIIAH 499

  Fly   417 -------DG-----------------KYEKLGYY-----------------DTQLDNLSWLNTEQ 440
                   ||                 |..:.|..                 ||..:.......::
Frog   500 RGFMWHLDGSGIPVSRCTPRCPPGQRKLPRRGQQHACCYDCVQCSEGMISNDTDREACQPCPEDK 564

  Fly   441 WIGGK----VPQDRTIVTHVLRTVSLPLFVCMCTISS-----CGIFVAFALIIFNIWNKHRRVIQ 496
            |...|    :|:....:::.....:|...:....:|.     .||||||         :|..:::
Frog   565 WPNQKKDQCLPRSSEFLSYQSDWKTLLFSIVSILLSGVTAIIVGIFVAF---------RHSPIVK 620

  Fly   497 SSHPVCNTIMLFGVIICLISVIL-LGIDGRFVSPEEYPKICQARAWLLSTGFTLAYGAMFSKVWR 560
            :::...:.::|..:::..:.|.| ||        ......|..|...:...|::...::.:|...
Frog   621 ANNQRLSFLLLGSIMMSFLCVFLFLG--------RPLHVTCMLRQTCMGIIFSVVVSSVLAKTIM 677

  Fly   561 VHRFTTKAKTDPKKKVEPWKL---------YTMVSGLLSIDLVILLSW-QIFDPLQRYLETFPLE 615
            | ....||    .|....||.         ..:...||.:.  |.::| .|..|......:||
Frog   678 V-CIVFKA----SKPGNYWKKCVGAKIPNGVVVACSLLQVS--ISIAWLSISPPFMELNRSFP-- 733

  Fly   616 DPVSTTDDIKIRPELEHCESQRNSMWLGLVYGFKGLILVFGLFLAYETRSIKVKQINDSRYVGMS 680
                    .||   |..| ::.:.:....|.|:.||:......:|:..|.:. ...|:::|:
Frog   734 --------GKI---LIQC-NEGSPVAFYAVLGYLGLLAAVSFIVAFLARKLP-DSFNEAKYI--- 782

  Fly   681 IYNVVVLCLITA---PVGMVIASQQDASFAFVALAVIFCCFLSMLLIFVPKVIEVIRHPKDKAE 741
            .::::|.|.:..   |..:.:..:.  :......|::...|..:..||.||...::..|:...:
Frog   783 TFSMLVFCSVWVSFIPAHLSVTGKN--TVVVEIFAIMASSFGVLASIFFPKCYIILIKPEQNTK 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361	96/515 (19%)
		ANF_receptor	52..415	CDD:279440	88/449 (20%)
		7tm_3	476..730	CDD:278433	50/267 (19%)
LOC100498444	XP_031751053.1	Periplasmic_Binding_Protein_type1	34..504	CDD:415822	90/458 (20%)
		NCD3G	512..566	CDD:400103	4/53 (8%)
		7tmC_V2R_pheromone	592..836	CDD:320410	52/287 (18%)
		TM helix 1	592..612	CDD:320410	4/19 (21%)
		TM helix 2	624..645	CDD:320410	3/20 (15%)
		TM helix 3	654..676	CDD:320410	3/21 (14%)
		TM helix 4	702..718	CDD:320410	3/17 (18%)
		TM helix 5	744..767	CDD:320410	4/22 (18%)
		TM helix 6	779..801	CDD:320410	4/24 (17%)
		TM helix 7	806..831	CDD:320410	4/26 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D590810at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010