DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R1 and gabbr1

DIOPT Version :9

Sequence 1:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_012823396.1	Gene:	gabbr1 / 100135080	XenbaseID:	XB-GENE-956617	Length:	987	Species:	Xenopus tropicalis

Alignment Length:	818	Identity:	406/818 - (49%)
Similarity:	559/818 - (68%)	Gaps:	32/818 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LCLIASP--HLQGGVAGRPDELHIGGIFPIAGKGGWQGGQACMPAARLALDDVNKQPNLLPGFKL 76
            :|.:..|  .::...:.|...||:|.:||::  |||.|||||.|||::||:|||.:.::||.::|
Frog   154 ICQVRRPDTSIRHPESSRKRALHVGALFPMS--GGWPGGQACQPAAQMALEDVNNRRDILPEYEL 216

  Fly    77 ILHSNDSECEPGLGASVMYNLLYNKPQKLMLLAGCSTVCTTVAEAAKMWNLIVLCYGASSPALSD 141
            .|..:||:|:||.....:|.||||.|.|:||:.|||:|.|.|||||:||:||||.||:||||||:
Frog   217 RLIHHDSQCDPGQATRYLYELLYNDPIKIMLMPGCSSVSTLVAEAARMWHLIVLSYGSSSPALSN 281

  Fly   142 RKRFPTLFRTHPSATVHNPTRIKLMKKFGWSRVAILQQAEEVFISTVEDLENRCMEAGVEIVTRQ 206
            |:||||.||||||||:|||||::|.||:||:::|.:||..|||.||::|||.|..|||:||..||
Frog   282 RQRFPTFFRTHPSATLHNPTRVQLFKKWGWTKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQ 346

  Fly   207 SFLSDPTDAVRNLRRQDARIIVGLFYVVAARRVLCEMYKQQLYGRAHVWFFIGWYEDNWYEVNLK 271
            ||.|||...|:||:|||||:||||||...||:|.||:||::|:|:.:|||.||||.|||:::...
Frog   347 SFFSDPAIPVKNLKRQDARVIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIPDP 411

  Fly   272 AEGITCTVEQMRIAAEGHLTTEALMWNQNNQTTISGMTAEEFRHRLNQALIEEGYDINHDRYPE- 335
            |  |.||||:|..|.|||:|||.:|.|..|...||.||::||..:|.:.|.|.         ||
Frog   412 A--INCTVEEMTQAVEGHVTTEIVMLNPENTRGISNMTSQEFMEKLKKRLGEN---------PEM 465

  Fly   336 --GYQEAPLAYDAVWSVALAFNKTMERLTTGKKSLRDFTYTDKEIADEIYAAMNSTQFLGVSGVV 398
              |.|||||||||:|::|||.|||...|:...:.|.||.|.:|.|::|||.||||:.|.||||.|
Frog   466 TGGLQEAPLAYDAIWALALALNKTAYELSKKGRRLEDFNYNNKMISEEIYRAMNSSSFDGVSGHV 530

  Fly   399 AFSSQGDRIALTQIEQMIDGKYEKLGYYDTQLDNLSWLNTEQWIGGKVPQDRTIVTHVLRTVSLP 463
            .|.:.|.|:|.|.|||:..|.|:|:||||:..|||||.|.::||||..|.|.|.|....|.||..
Frog   531 VFDASGSRMAWTLIEQLQGGVYKKIGYYDSTKDNLSWYNNDKWIGGSPPADHTKVIITFRYVSQK 595

  Fly   464 LFVCMCTISSCGIFVAFALIIFNIWNKHRRVIQSSHPVCNTIMLFGVIICLISVILLGIDGRFVS 528
            ||:.:..::..||.:.|..:.|||:|.|.|.||:|.|..|.:...|.|:.|.:|..||:|||.:.
Frog   596 LFISVSVLAGLGILLGFVCLSFNIYNSHVRYIQNSQPHLNDVTAAGCILSLAAVFPLGLDGRHIE 660

  Fly   529 PEEYPKICQARAWLLSTGFTLAYGAMFSKVWRVHRFTTKAKTDPKKK------VEPWKLYTMVSG 587
            ...:|.:||||.|||..||:||||:||:|:|.:|...|| |.|.|::      :|||||||.||.
Frog   661 TWHFPLVCQARLWLLGLGFSLAYGSMFTKIWWIHTAFTK-KDDKKERRKQSQTLEPWKLYTTVSL 724

  Fly   588 LLSIDLVILLSWQIFDPLQRYLETFPLEDPVSTTDDIKIRPELEHCESQRNSMWLGLVYGFKGLI 652
            ||.:|::.|..|||.|||||.:|.|..|:|.... |:.|.|:||||.|.:.:.|||:|||.|||:
Frog   725 LLGLDVITLGIWQIVDPLQRSIEEFTKEEPRGDL-DVLILPQLEHCSSLKMNTWLGIVYGSKGLL 788

  Fly   653 LVFGLFLAYETRSIKVKQINDSRYVGMSIYNVVVLCLITAPVGMVIASQQDASFAFVALAVIFCC 717
            |:.|:||||||:|:..::|||.|.|||:||||.|||||||||.|:::|||||||||.:||::|..
Frog   789 LLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDASFAFSSLAIVFSA 853

  Fly   718 FLSMLLIFVPKVIEVIRHPKDKAESK--YNPDSAISKEDEERYQKLVTENEELQRLITQKEEKIR 780
            :::::::||||:..:|...:.::|.:  ....|:.:..:||:.:.|..||:||.|:|.:|||::.
Frog   854 YITLVVLFVPKMRRLITRGEWQSEQQDTLKTGSSTNNNEEEKSRLLERENQELGRIIAEKEERVM 918

  Fly   781 VLRQRLVERG----DAKGTELNGATGVASAAVATTSQP 814
            .|||:|..|.    .|:....:.....:|.||::..||
Frog   919 ELRQQLRSRRRPSVPARDNCSDNHFPNSSGAVSSLYQP 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361	227/405 (56%)
		ANF_receptor	52..415	CDD:279440	204/365 (56%)
		7tm_3	476..730	CDD:278433	134/259 (52%)
gabbr1	XP_012823396.1	CCP	104..156	CDD:153056	0/1 (0%)
		PBP1_GABAb_receptor	176..575	CDD:380589	229/411 (56%)
		7tmC_GABA-B-R1	595..870	CDD:320418	137/276 (50%)
		TM helix 1	595..620	CDD:320418	7/24 (29%)
		TM helix 2	632..653	CDD:320418	6/20 (30%)
		TM helix 3	669..693	CDD:320418	16/23 (70%)
		TM helix 4	718..738	CDD:320418	10/19 (53%)
		TM helix 5	774..800	CDD:320418	16/25 (64%)
		TM helix 6	809..832	CDD:320418	18/22 (82%)
		TM helix 7	839..864	CDD:320418	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	413	1.000	Domainoid score	I670
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1132
Inparanoid	1	1.050	793	1.000	Inparanoid score	I500
OMA	1	1.010	-	-		QHG49267
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	1	1.000	-	-		FOG0006100
OrthoInspector	1	1.000	-	-		oto103236
Panther	1	1.100	-	-	LDO	PTHR10519
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3034
SonicParanoid	1	1.000	-	-		X4397
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110