DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment THG and THG1L

DIOPT Version :9

Sequence 1:	NP_001188815.1	Gene:	THG / 34876	FlyBaseID:	FBgn0283659	Length:	286	Species:	Drosophila melanogaster
Sequence 2:	NP_060342.2	Gene:	THG1L / 54974	HGNCID:	26053	Length:	298	Species:	Homo sapiens

Alignment Length:	265	Identity:	145/265 - (54%)
Similarity:	187/265 - (70%)	Gaps:	19/265 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MACSRFEYVKSFEQDDSILPNVWIVIRIDGKKFHKFSKTHDFEKPNDENALNVMNAAATAVMQEF 65
            ||.|:||||:.||.||:.|.:.|:|:|:||:.||:|::.|:|.||||..||.:|...|..||:|.
Human    30 MAKSKFEYVRDFEADDTCLAHCWVVVRLDGRNFHRFAEKHNFAKPNDSRALQLMTKCAQTVMEEL 94

  Fly    66 RDIVLAYGQSDEYSFVFRKETAAFKRRSAKLLTYVTSLFSSSYVMQWSKWM-NLPLAYAPCFDGR 129
            .|||:||||||||||||:::|..||||::|.:|:|.|.|:||||..|..:. :.||.|.|.||||
Human    95 EDIVIAYGQSDEYSFVFKRKTNWFKRRASKFMTHVASQFASSYVFYWRDYFEDQPLLYPPGFDGR 159

  Fly   130 VVLYPSEQNLKDYLSWRQADVHVNNLYNTAFWKLVLEKGLTNQQAEAKLRGTFSADKNELLFQEF 194
            ||:|||.|.|||||||||||.|:||||||.||.|:.:.|||..||:.:|:||.:|||||:||.||
Human   160 VVVYPSNQTLKDYLSWRQADCHINNLYNTVFWALIQQSGLTPVQAQGRLQGTLAADKNEILFSEF 224

  Fly   195 GINYNNLPAMYRKGTILLRKRV-------------ILGEK-----SRQAVVPLHEDLISSQFWKE 241
            .|||||...||||||:|:.::|             :.|:|     :|...||||.|:|...||||
Human   225 NINYNNELPMYRKGTVLIWQKVDEVMTKEIKLPTEMEGKKMAVTRTRTKPVPLHCDIIGDAFWKE 289

  Fly   242 HTEIL 246
            |.|||
Human   290 HPEIL 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
THG	NP_001188815.1	Thg1	2..239	CDD:226508	136/255 (53%)
		Thg1	9..134	CDD:282322	67/125 (54%)
		Thg1C	137..234	CDD:291110	60/114 (53%)
THG1L	NP_060342.2	Thg1	31..291	CDD:226508	140/259 (54%)
		Thg1	38..164	CDD:282322	67/125 (54%)
		Thg1C	167..282	CDD:291110	60/114 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159418
Domainoid	1	1.000	158	1.000	Domainoid score	I4107
eggNOG	1	0.900	-	-		E1_COG4021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5959
Inparanoid	1	1.050	296	1.000	Inparanoid score	I2751
Isobase	1	0.950	-	0	Normalized mean entropy	S995
OMA	1	1.010	-	-		QHG54375
OrthoDB	1	1.010	-	-		D1152974at2759
OrthoFinder	1	1.000	-	-		FOG0004478
OrthoInspector	1	1.000	-	-		oto88514
orthoMCL	1	0.900	-	-		OOG6_103009
Panther	1	1.100	-	-	LDO	PTHR12729
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1510
SonicParanoid	1	1.000	-	-		X3173
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750