DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NC2beta and DR1

DIOPT Version :9

Sequence 1:	NP_609736.1	Gene:	NC2beta / 34875	FlyBaseID:	FBgn0028926	Length:	183	Species:	Drosophila melanogaster
Sequence 2:	NP_001929.1	Gene:	DR1 / 1810	HGNCID:	3017	Length:	176	Species:	Homo sapiens

Alignment Length:	171	Identity:	105/171 - (61%)
Similarity:	133/171 - (77%)	Gaps:	0/171 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SAEDDELTLPRASINKIIKELVPTVRVANESRELILNCCSEFIHLISSEANEVCNMRNKKTINAE 76
            |..||:||:|||:|||:|||.:|.|||||::|||::|||:||||||||||||:||...||||:.|
Human     5 SGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPE 69

  Fly    77 HVLEALERLGFHDYKQEAEAVLHDCKEVAAKRRRQSTRLENLGIPEEELLRQQQELFAKAREEQA 141
            ||::|||.|||..|..|.:.||.:||.||.|||:.|:||||||||||||||||||||||||::||
Human    70 HVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKARQQQA 134

  Fly   142 REEQQQWMSMQAAAMVQRPPLADGSVASKPSEDDDDDDDDD 182
            ...||:|:.||.||...:...|..|.:::.....|::||||
Human   135 ELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDD 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NC2beta	NP_609736.1	H4	15..135	CDD:304892	84/119 (71%)
DR1	NP_001929.1	H4	7..130	CDD:419976	86/122 (70%)
		Nuclear localization signal. /evidence=ECO:0000255	100..103		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..176		7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149204
Domainoid	1	1.000	114	1.000	Domainoid score	I6101
eggNOG	1	0.900	-	-		E1_COG5150
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38809
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3570
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55130
OrthoDB	1	1.010	-	-		D1465912at2759
OrthoFinder	1	1.000	-	-		FOG0004284
OrthoInspector	1	1.000	-	-		oto90126
orthoMCL	1	0.900	-	-		OOG6_103431
Panther	1	1.100	-	-	LDO	PTHR46138
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R797
SonicParanoid	1	1.000	-	-		X3019
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800