Protein Alignment l(2)35Be and CASKIN1

DIOPT Version :9

• Sequence 1: NP_609735.1
• Gene: l(2)35Be / 34874
• FlyBaseID: FBgn0261881
• Length: 215
• Species: Drosophila melanogaster
• Sequence 2: NP_065815.1
• Gene: CASKIN1 / 57524
• HGNCID: 20879
• Length: 1431
• Species: Homo sapiens
• Alignment Length: 200
• Identity: 53/200 - (26%)
• Similarity: 81/200 - (40%)
• Gaps: 54/200 - (27%)

  Fly    36 ELIEEDKNPQSSIE-------RMILWAVNENRISEVREILKLDADTVNAKDNDGYTPLHRAAYNN 93
            |||......|::::       |.:.:|..:.|...::.:||. ...||...::|:.|||.||.:.
Human    63 ELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKA-GSAVNIPSDEGHIPLHLAAQHG 126

  Fly    94 FVDMAKLLLQYHANP-----NARTEL------------------------------------GWT 117
            ..|::::|||:.:||     :.:|.|                                    |.:
Human   127 HYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTS 191

  Fly   118 PLHSACKWNNADCAHLLLQFGADVNAESDGKQTPLHITATVSNCRNTATV-LLLDRYIQPRKENN 181
            |||.|.|..:.|...||||.|.|:|.::. ..|.||..|.   |..|..| ||||..|.....|.
Human   192 PLHLAAKNGHIDIIRLLLQAGIDINRQTK-SGTALHEAAL---CGKTEVVRLLLDSGINAHVRNT 252

  Fly   182 SEELA 186
            ..:.|
Human   253 YSQTA 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)35Be	NP_609735.1	ANK repeat	52..79	CDD:293786	6/26 (23%)
		ANK	54..169	CDD:238125	41/156 (26%)
		Ank_5	67..120	CDD:290568	20/93 (22%)
		ANK repeat	81..112	CDD:293786	12/35 (34%)
		Ank_5	100..154	CDD:290568	23/94 (24%)
		ANK repeat	114..144	CDD:293786	15/65 (23%)
		ANK repeat	147..180	CDD:293786	12/33 (36%)
CASKIN1	NP_065815.1	Ank_4	7..69	CDD:290365	3/5 (60%)
		ANK repeat	7..46	CDD:293786
		ANK	43..168	CDD:238125	25/105 (24%)
		ANK repeat	48..79	CDD:293786	4/15 (27%)
		ANK 1	48..77		4/13 (31%)
		Ank_2	53..145	CDD:289560	23/82 (28%)
		ANK repeat	81..112	CDD:293786	7/31 (23%)
		ANK 2	81..110		6/29 (21%)
		ANK	109..241	CDD:238125	37/135 (27%)
		ANK repeat	114..145	CDD:293786	12/30 (40%)
		ANK 3	114..143		12/28 (43%)
		Ank_2	119..218	CDD:289560	26/98 (27%)
		ANK repeat	147..186	CDD:293786	2/38 (5%)
		ANK 4	147..176		2/28 (7%)
		ANK repeat	188..218	CDD:293786	14/29 (48%)
		ANK 5	188..217		13/28 (46%)
		Ank_5	208..261	CDD:290568	19/53 (36%)
		ANK 6	220..249		12/32 (38%)
		ANK repeat	221..251	CDD:293786	12/32 (38%)
		ANK repeat	253..287	CDD:293786	0/4 (0%)
		SH3_Caskin1	284..345	CDD:212995
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..373
		Caskin1-CID	373..421	CDD:293208
		CASK-binding. /evidence=ECO:0000250	375..469
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..406
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..447
		SAM	470..532	CDD:197735
		SAM_caskin1,2_repeat1	471..536	CDD:188896
		SAM_caskin1,2_repeat2	537..607	CDD:188897
		SAM	549..604	CDD:197735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	630..977
		Ten_N	<651..>809	CDD:284015
		Caskin-Pro-rich	876..947	CDD:293512
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1014..1039
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1072..1377
		Caskin-tail	1370..1431	CDD:293238
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1390..1416

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910