DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)35Be and ankrd49

DIOPT Version :9

Sequence 1:	NP_609735.1	Gene:	l(2)35Be / 34874	FlyBaseID:	FBgn0261881	Length:	215	Species:	Drosophila melanogaster
Sequence 2:	NP_001017584.2	Gene:	ankrd49 / 550246	ZFINID:	ZDB-GENE-050417-46	Length:	218	Species:	Danio rerio

Alignment Length:	210	Identity:	80/210 - (38%)
Similarity:	118/210 - (56%)	Gaps:	15/210 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DSDDEKSQVEKLRHAKVPRGMFVSGWDDDADELIEEDK-------------NPQSSIERMILWAV 56
            |..::.:|:|.|....:|.|. .|.|.:: :|..|||:             :.|.:...::|||.
Zfish     2 DFPEDFNQLELLDPHVIPMGT-RSNWAEE-EEGEEEDEAMHTEEWHQQQELHLQDTPSELMLWAA 64

  Fly    57 NENRISEVREILKLDADTVNAKDNDGYTPLHRAAYNNFVDMAKLLLQYHANPNARTELGWTPLHS 121
            ..||.:.|..::.||...||..|:|||||||||||:...|:|..||:..||.:|||...|.||||
Zfish    65 ERNRCATVERLIALDPTLVNCHDSDGYTPLHRAAYSGHHDVASALLKAGANLHARTADDWMPLHS 129

  Fly   122 ACKWNNADCAHLLLQFGADVNAESDGKQTPLHITATVSNCRNTATVLLLDRYIQPRKENNSEELA 186
            ||:|.:|:.|.||||:|::|||.:.|:.|||.:.|..:....|..:||..|.::...:|::.|.|
Zfish   130 ACRWGHANVASLLLQWGSEVNAMTAGRLTPLQLAAGNAAAGKTIELLLSQRTLEAGLKNSAGETA 194

  Fly   187 SVIARRTGMSFPIFE 201
            ..||.||.....:||
Zfish   195 YDIAHRTSELHRLFE 209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)35Be	NP_609735.1	ANK repeat	52..79	CDD:293786	10/26 (38%)
		ANK	54..169	CDD:238125	54/114 (47%)
		Ank_5	67..120	CDD:290568	27/52 (52%)
		ANK repeat	81..112	CDD:293786	18/30 (60%)
		Ank_5	100..154	CDD:290568	29/53 (55%)
		ANK repeat	114..144	CDD:293786	17/29 (59%)
		ANK repeat	147..180	CDD:293786	9/32 (28%)
ankrd49	NP_001017584.2	ANK	62..166	CDD:238125	53/103 (51%)
		Ank_2	62..151	CDD:289560	46/88 (52%)
		ANK repeat	89..120	CDD:293786	18/30 (60%)
		ANK repeat	122..151	CDD:293786	16/28 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0512
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9787
Inparanoid	1	1.050	133	1.000	Inparanoid score	I4588
OMA	1	1.010	-	-		QHG48821
OrthoDB	1	1.010	-	-		D1546307at2759
OrthoFinder	1	1.000	-	-		FOG0007458
OrthoInspector	1	1.000	-	-		oto38614
orthoMCL	1	0.900	-	-		OOG6_107702
Panther	1	1.100	-	-	LDO	PTHR24144
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4168
SonicParanoid	1	1.000	-	-		X5588
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800