DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)35Be and ANK3

DIOPT Version :9

Sequence 1:	NP_609735.1	Gene:	l(2)35Be / 34874	FlyBaseID:	FBgn0261881	Length:	215	Species:	Drosophila melanogaster
Sequence 2:	NP_066267.2	Gene:	ANK3 / 288	HGNCID:	494	Length:	4377	Species:	Homo sapiens

Alignment Length:	141	Identity:	49/141 - (34%)
Similarity:	75/141 - (53%)	Gaps:	5/141 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 AVNENRISEVREILKLDADTVNAKDNDGYTPLHRAAYNNFVDMAKLLLQYHANPNARTELGWTPL 119
            |..|..:..|..:|..:|: ||..:..|.||||.||..:.|::|::|:...|:.:|:|::|:|||
Human   671 AAQEGHVDMVSLLLGRNAN-VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPL 734

  Fly   120 HSACKWNNADCAHLLLQFGADVNAESDGKQTPLHITATVSNCRNTATV-LLLDRYIQPRKENNSE 183
            |..|.:.|....:.|||..|.|||::....||||..|...   :|..: :||.....|.:...:.
Human   735 HVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQG---HTHIINVLLQNNASPNELTVNG 796

  Fly   184 ELASVIARRTG 194
            ..|..||||.|
Human   797 NTALGIARRLG 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)35Be	NP_609735.1	ANK repeat	52..79	CDD:293786	7/23 (30%)
		ANK	54..169	CDD:238125	40/114 (35%)
		Ank_5	67..120	CDD:290568	20/52 (38%)
		ANK repeat	81..112	CDD:293786	12/30 (40%)
		Ank_5	100..154	CDD:290568	21/53 (40%)
		ANK repeat	114..144	CDD:293786	13/29 (45%)
		ANK repeat	147..180	CDD:293786	9/33 (27%)
ANK3	NP_066267.2	ANK 6	234..263
		ANK repeat	267..298	CDD:293786
		ANK 7	267..296
		Ank_2	272..363	CDD:289560
		ANK	295..420	CDD:238125
		ANK 8	300..329
		ANK repeat	300..325	CDD:293786
		ANK repeat	333..364	CDD:293786
		ANK 9	333..362
		ANK	361..486	CDD:238125
		ANK 10	366..395
		ANK repeat	369..397	CDD:293786
		Ank_2	371..463	CDD:289560
		ANK repeat	399..430	CDD:293786
		ANK 11	399..428
		ANK repeat	432..463	CDD:293786
		ANK 12	432..461
		ANK	460..585	CDD:238125
		ANK repeat	465..496	CDD:293786
		ANK 13	465..494
		Ank_2	470..561	CDD:289560
		ANK repeat	498..529	CDD:293786
		ANK 14	498..527
		ANK repeat	531..560	CDD:293786
		ANK 15	531..560
		Ank_2	536..626	CDD:289560
		ANK	560..684	CDD:238125	3/12 (25%)
		ANK repeat	564..593	CDD:293786
		ANK 16	564..593
		ANK repeat	597..626	CDD:293786
		ANK 17	597..626
		ANK repeat	630..660	CDD:293786
		ANK 18	630..659
		Ank_4	631..684	CDD:290365	3/12 (25%)
		ANK	658..783	CDD:238125	40/115 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Ank_4	47..94	CDD:290365
		ANK	68..193	CDD:238125
		ANK repeat	73..104	CDD:293786
		ANK 1	73..102
		Ank_2	78..164	CDD:289560
		ANK repeat	106..137	CDD:293786
		ANK 2	106..135
		ANK 3	139..168
		ANK repeat	139..164	CDD:293786
		Ank_4	140..193	CDD:290365
		ANK 4	172..201
		ANK 5	203..230
		ANK repeat	205..232	CDD:293786
		Ank_2	206..297	CDD:289560
		ANK	229..354	CDD:238125
		ANK repeat	234..265	CDD:293786
		ANK repeat	663..694	CDD:293786	7/23 (30%)
		ANK 19	663..692		6/21 (29%)
		Ank_2	669..759	CDD:289560	33/88 (38%)
		ANK repeat	696..727	CDD:293786	12/30 (40%)
		ANK 20	696..725		11/28 (39%)
		ANK repeat	729..760	CDD:293786	14/30 (47%)
		ANK 21	729..758		12/28 (43%)
		Ank_5	749..803	CDD:290568	17/56 (30%)
		ANK 22	762..791		9/31 (29%)
		ANK repeat	762..790	CDD:293786	8/30 (27%)
		ANK 23	795..825		6/13 (46%)
		ZU5	982..1086	CDD:128514
UPA domain. /evidence=ECO:0000250	1273..1407
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1519..1540
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1968..1987
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2107..2159
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2176..2245
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2299..2322
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2383..2433
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2474..2508
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2588..2751
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2795..2824
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3036..3067
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3131..3272
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3298..3516
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3538..3607
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3635..3718
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3868..3897
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4019..4090
Death_ank3	4088..4171	CDD:176781
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4251..4298
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4323..4377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910