DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)35Be and ASZ1

DIOPT Version :9

Sequence 1:	NP_609735.1	Gene:	l(2)35Be / 34874	FlyBaseID:	FBgn0261881	Length:	215	Species:	Drosophila melanogaster
Sequence 2:	NP_570124.1	Gene:	ASZ1 / 136991	HGNCID:	1350	Length:	475	Species:	Homo sapiens

Alignment Length:	203	Identity:	50/203 - (24%)
Similarity:	78/203 - (38%)	Gaps:	58/203 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AKVPRGMFVSGW------DDDADELIEEDKNPQSSIERMILWAVNENRISEVREILKLDADTVNA 77
            |...||:.|:|.      :||..|:...|:..| .::|::       .|.|.:|..|
Human     3 ASALRGLPVAGGGESSESEDDGWEIGYLDRTSQ-KLKRLL-------PIEEKKEKFK-------- 51

  Fly    78 KDNDGYTPLHRAAYNNFVDMAKLLLQYHANPNARTELGWTPLHSACKWNNADCAHLLLQFGADVN 142
                      :|.....|.:.:.||....:.::..:.|||||..|....||:...:||..||:.:
Human    52 ----------KAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANAS 106

  Fly   143 AESDGKQTPLHITA--------TVSNCRNTATVLLLDRYIQPRKENNSEELASVIARRTGMSFPI 199
            .|.| ||:.| |||        .:..|    ..|||.|...|          :|..||  :..||
Human   107 FEKD-KQSIL-ITACSAHGSEEQILKC----VELLLSRNADP----------NVACRR--LMTPI 153

  Fly   200 FESGEEAY 207
            ..:..:.:
Human   154 MYAARDGH 161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)35Be	NP_609735.1	ANK repeat	52..79	CDD:293786	4/26 (15%)
		ANK	54..169	CDD:238125	29/122 (24%)
		Ank_5	67..120	CDD:290568	9/52 (17%)
		ANK repeat	81..112	CDD:293786	4/30 (13%)
		Ank_5	100..154	CDD:290568	19/53 (36%)
		ANK repeat	114..144	CDD:293786	12/29 (41%)
		ANK repeat	147..180	CDD:293786	12/40 (30%)
ASZ1	NP_570124.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		7/21 (33%)
		ANK 1. /evidence=ECO:0000305	45..74		7/46 (15%)
		ANK	78..202	CDD:238125	31/102 (30%)
		ANK repeat	78..109	CDD:293786	12/30 (40%)
		ANK 2. /evidence=ECO:0000305	78..107		12/28 (43%)
		ANK repeat	110..146	CDD:293786	14/51 (27%)
		ANK 3. /evidence=ECO:0000305	110..144		13/49 (27%)
		ANK repeat	148..179	CDD:293786	3/16 (19%)
		ANK 4. /evidence=ECO:0000305	148..177		3/16 (19%)
		ANK	176..>234	CDD:238125
		ANK 5. /evidence=ECO:0000305	181..210
		ANK repeat	181..206	CDD:293786
		ANK 6. /evidence=ECO:0000305	214..243
		SAM_ASZ1	272..334	CDD:188920
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910