DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)35Be and AgaP_AGAP007813

DIOPT Version :9

Sequence 1:	NP_609735.1	Gene:	l(2)35Be / 34874	FlyBaseID:	FBgn0261881	Length:	215	Species:	Drosophila melanogaster
Sequence 2:	XP_317687.3	Gene:	AgaP_AGAP007813 / 1278145	VectorBaseID:	AGAP007813	Length:	235	Species:	Anopheles gambiae

Alignment Length:	218	Identity:	120/218 - (55%)
Similarity:	154/218 - (70%)	Gaps:	6/218 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DYDSDDEKSQVEKL-----RHAKVPRGMFVSGWDDDADELIEEDKNPQSSIERMILWAVNENRIS 62
            |..:::|:.:::.|     :.:||||||||||| ||.|:||||||.|.:|.||.:|||..||:..
Mosquito    19 DDAAEEEEEEMDTLEALEAKMSKVPRGMFVSGW-DDPDDLIEEDKEPNASYERQVLWAAGENKQE 82

  Fly    63 EVREILKLDADTVNAKDNDGYTPLHRAAYNNFVDMAKLLLQYHANPNARTELGWTPLHSACKWNN 127
            .|..|:......|.|.|.||||.||:|.|||..:||.:||:|.::|||||::|||||||||||||
Mosquito    83 IVEAIVCRKPCVVEAIDRDGYTALHKACYNNNREMAMVLLRYGSDPNARTDMGWTPLHSACKWNN 147

  Fly   128 ADCAHLLLQFGADVNAESDGKQTPLHITATVSNCRNTATVLLLDRYIQPRKENNSEELASVIARR 192
            |.||.||||.||||||.|||.|||||||.|||:||:|...||::....|.:.|||:|.|..||:|
Mosquito   148 AGCAALLLQHGADVNAPSDGDQTPLHITVTVSSCRSTLVTLLMNGRCDPERRNNSDEKAEQIAKR 212

  Fly   193 TGMSFPIFESGEEAYDCETGLID 215
            :|.:||:|.....|:..|||:||
Mosquito   213 SGDTFPLFAMAHSAFTVETGMID 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)35Be	NP_609735.1	ANK repeat	52..79	CDD:293786	9/26 (35%)
		ANK	54..169	CDD:238125	71/114 (62%)
		Ank_5	67..120	CDD:290568	28/52 (54%)
		ANK repeat	81..112	CDD:293786	18/30 (60%)
		Ank_5	100..154	CDD:290568	41/53 (77%)
		ANK repeat	114..144	CDD:293786	25/29 (86%)
		ANK repeat	147..180	CDD:293786	17/32 (53%)
AgaP_AGAP007813	XP_317687.3	Ank_2	57..131	CDD:289560	37/73 (51%)
		ANK	74..190	CDD:238125	72/115 (63%)
		ANK repeat	101..132	CDD:293786	18/30 (60%)
		Ank_2	106..200	CDD:289560	61/93 (66%)
		ANK repeat	134..165	CDD:293786	26/30 (87%)
		ANK repeat	167..200	CDD:293786	17/32 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	80	1.000	Domainoid score	I15444
eggNOG	1	0.900	-	-		E2759_KOG0512
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9787
Inparanoid	1	1.050	242	1.000	Inparanoid score	I5684
OMA	1	1.010	-	-		QHG48821
OrthoDB	1	1.010	-	-		D1546307at2759
OrthoFinder	1	1.000	-	-		FOG0007458
OrthoInspector	1	1.000	-	-		oto108873
Panther	1	1.100	-	-	LDO	PTHR24144
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5588
TreeFam	1	0.960	-	-
	13	12.940