DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mol and Duoxa1

DIOPT Version :9

Sequence 1:	NP_001036362.1	Gene:	mol / 34872	FlyBaseID:	FBgn0086711	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001292191.1	Gene:	Duoxa1 / 213696	MGIID:	2384861	Length:	341	Species:	Mus musculus

Alignment Length:	373	Identity:	114/373 - (30%)
Similarity:	170/373 - (45%)	Gaps:	55/373 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GPTLYSFSNRTPV-TGDVSIVAVSVLFATFYVAFLVIFPGVR-KQKFTTFSTVTLSLFVGLVILI 75
            |.||..::...|. ..|.::..:..:|.|..|.|::|.||:| |.:......|..|||:|.|||.
Mouse     5 GHTLPFYTGTKPTFPMDTTLAVIITIFLTALVTFIIILPGIRGKTRLFWLLRVVTSLFIGAVILA 69

  Fly    76 TRLGSAWHVAHATIIAPYKAFSREKLPARIGTHIGLMHVNVTLTAIPIG--NWTPPDIDYNERFT 138
            ....|.|.|.|......|||||.:.:...:|..|||..||:|||..|:.  |.|   |:|||.|.
Mouse    70 VNFSSEWSVGHVNANTTYKAFSPKWVSVDVGLQIGLGGVNITLTGTPVQQLNET---INYNEAFA 131

  Fly   139 WEGANDMSANYRHALQRGLPFPILTVAEYFSLGREGFSWGGQYRAAGYFASIMLWASLASWLLMN 203
            |......:..|..||::|||.|:|.:||.|: .|.......|||.||::||.|||.:...|||.|
Mouse   132 WRLGRSYAEEYAKALEKGLPDPVLYLAEKFT-PRSPCGLYNQYRLAGHYASAMLWVAFLCWLLAN 195

  Fly   204 LLL-IAVPRYGAYMKALTGALLVCTTVGYHCLLPK--RPLSIHLEGGRLEFHFGWCYWLVLVAGI 265
            ::| :.|..||.:|...|| |.....:.:..:...  .|..:.|....|..|.|..:|:.|..|:
Mouse   196 VMLSMPVLVYGGHMLLATG-LFQLLALFFFSMTTSLISPCPLRLGTAVLHTHHGPAFWITLATGL 259

  Fly   266 LCFIAGVLISIIDLVWPHTFSTVLEVYYGTPYDRHVILEESSDVRYRKPRNSRSLEDPPGLGSRI 330
            ||.:.|:::::...:.||.    |:.::                       ::|.|||      :
Mouse   260 LCILLGLVMAVAHRMQPHR----LKAFF-----------------------NQSSEDP------V 291

  Fly   331 LRRLSSKARDLQP-----GTAPR-RDSPAGVSSSGGVENKGFQSDAPK 372
            |...|.:...|.|     ..:|. :|.|..|:||    ...|:.:.||
Mouse   292 LEWGSEEGGLLSPHYRSIAESPETQDIPMSVASS----ETCFKEEHPK 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mol	NP_001036362.1	DuoxA	18..289	CDD:287209	93/277 (34%)
Duoxa1	NP_001292191.1	DuoxA	11..283	CDD:402003	94/280 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832409
Domainoid	1	1.000	154	1.000	Domainoid score	I4249
eggNOG	1	0.900	-	-		E1_KOG3921
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H16043
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4305
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D360121at33208
OrthoFinder	1	1.000	-	-		FOG0003131
OrthoInspector	1	1.000	-	-		otm43112
orthoMCL	1	0.900	-	-		OOG6_106442
Panther	1	1.100	-	-	O	PTHR31158
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7905
SonicParanoid	1	1.000	-	-		X3013
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790