DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3491 and Sbno2

DIOPT Version :9

Sequence 1:	NP_609731.1	Gene:	CG3491 / 34870	FlyBaseID:	FBgn0028887	Length:	1801	Species:	Drosophila melanogaster
Sequence 2:	NP_906271.1	Gene:	Sbno2 / 216161	MGIID:	2448490	Length:	1349	Species:	Mus musculus

Alignment Length:	1281	Identity:	563/1281 - (43%)
Similarity:	748/1281 - (58%)	Gaps:	144/1281 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   543 SENKAF--PKP---NQVCIPPQPAIPPQPAIPPAPAYCMANKTMDTGMSSVVQMANNPLASTQHH 602
            |||:.|  ..|   .|.|  |:.:.|....:   |::...:.......|.:..::|..:.|:...
Mouse    49 SENQQFVGSTPFLGGQSC--PETSYPTTATV---PSFFSKSSDFPQDPSCLEDLSNASVFSSSVD 108

  Fly   603 ALPQVPIVTR-LKVDQGEDVSVKFTTGLDGLITNVQLLPSTMAMGQPTVKATELESFTAQQLNML 666
            :|..:|.... |:.|...:|                          ||:......|.|..:|  .
Mouse   109 SLSDIPDTPDFLQADSLNEV--------------------------PTIWDVSTTSTTHDKL--F 145

  Fly   667 LQSGHPYLSLPMTNSGVPGAVLQET---LQTKDAGFPSEQAVEDEEVDYEEIGVADTFAAYWPSK 728
            :.||      |.:....|...|..|   :..:....|.|:..|:|| :.||:|.|:|:|.|.|||
Mouse   146 IPSG------PFSAPEDPVTSLSSTPLLISYQSHSQPEEEEGEEEE-ETEELGHAETYADYVPSK 203

  Fly   729 LKFGRAHPDPVVETATLSSVELPNINYQLALPSKTTECLSALQLEAVVYACQAHEQILPSGDRAG 793
            .|.|:.|||.||||:|||||..|:|.|.||||:.....||||||||:.||||.||.:||||.|||
Mouse   204 SKIGKQHPDRVVETSTLSSVPPPDITYTLALPTSDNSTLSALQLEAITYACQQHEVLLPSGQRAG 268

  Fly   794 FLLGDGAGVGKGRTIAGIIFDNYLKGRKRALWVSVSSDLKFDAERDLADIGAHEKIRVATINKFK 858
            ||:|||||||||||:||||.:|||:|||:|||.|.|:|||:||||||.||.| ..|.|..::|.|
Mouse   269 FLIGDGAGVGKGRTVAGIIVENYLRGRKKALWFSASNDLKYDAERDLRDIEA-PGIAVHALSKIK 332

  Fly   859 YSPIDSEENENFKRGVIFCTYTALIGESMTTNSKYKTRFRQLTNWLGKKFEGVIVFDECHKAKNL 923
            |.  |:..:|    ||:|.||:||||||. ...:::||.||:..|.|:.|:|||||||||||||.
Mouse   333 YG--DNTTSE----GVLFATYSALIGESQ-AGGQHRTRLRQILQWCGEGFDGVIVFDECHKAKNA 390

  Fly   924 SLMNVGKSTKTGTTVLDLQKLLPNARVVYASATGASEPRNMAYMVRLGLWGPGTAYPEFYEFVNA 988
            |      |||.|..|||||..||.|||||||||||||||||.||.|||:||.||.:..|.||::|
Mouse   391 S------STKMGKAVLDLQSKLPQARVVYASATGASEPRNMIYMSRLGIWGEGTPFRTFEEFLHA 449

  Fly   989 VEKRGIGAMEIVAMDMKLRGTYIARQLSFKDVSFRIEEVNMSKEFRKSYNLSAELWADIHKKFQK 1053
            :||||:|||||||||||:.|.||||||||..|:|||||:.:|..|::.||.:|.|||:....||:
Mouse   450 IEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLSPAFQQVYNRAARLWAEALSVFQQ 514

  Fly  1054 ACRLMCVENRVQKIITCQFWCAHQRFFKNLCIASKVNHVVKMTRQATRMGKAVVIGLQSTGESRT 1118
            |...:.:|:|  |.:..|||.|||||||.||||:||:.:|::.:|.....|.||||||||||:||
Mouse   515 AADWIGLESR--KSLWGQFWSAHQRFFKYLCIAAKVHRLVELAQQELSRDKCVVIGLQSTGEART 577

  Fly  1119 LEHLERHHGKLNSFVSTAKMIIQSFVEKHFPAPKRDSFHHLLNTGEFEPEARSRPPKQKKSKMNT 1183
            .|.|:.:.|:|:.|||.|:.:..|.::||||:.:|   ......|:.:...|.|.||..:..:..
Mouse   578 REVLDENEGRLDCFVSAAEGVFLSLIQKHFPSTRR---RRDRGGGKRKRRPRGRGPKASRLSLEA 639

  Fly  1184 DWVEDDMDAEAGESDIEM---YERSCTAAVEKIKSGQKRRGRPPKADKVEKITMQERILEHLCNN 1245
            ..|....|..:.|||..:   :..|..:.|:               |.|..:
Mouse   640 AGVIRISDGSSTESDAGLDSDFNSSPESLVD---------------DDVVIV------------- 676

  Fly  1246 MREQDNEDESTNTSDNTKVKVNITERD------VERCINMREMLLEKIDVLGRKLPPNTLDKLIS 1304
                   |..|:.:|: :..:...:||      |||...:::.||.|:..|||:||.||||:||.
Mouse   677 -------DAPTHPTDD-RGSLYPLQRDLQGPGVVERVERLKQGLLAKVRALGRELPVNTLDQLIH 733

  Fly  1305 ELGGTNLVAEMTGRRGRVVRTEYDGYKYEPRCENDSTMDLVNYREKQRFMDGSKHVAIISEAASS 1369
            :|||...|||||||:||||........:|.|.|...::|.||.|||||||.|.|.|||||||:||
Mouse   734 QLGGPECVAEMTGRKGRVVSRPDGTVVFESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSS 798

  Fly  1370 GISLQSDKRVSNQRRRLHITLELPWSADRAIQQFGRTHRSNQVNAPEYVFVITDLAGERRFASTV 1434
            |:|||:|:||.|||||:|:||||||||||||||||||||||||:||||||:|::|||||||||.|
Mouse   799 GVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIV 863

  Fly  1435 AKRLESLGALTQGDRRATDARDLSQFNIDNSIGRSALENVMQQL---TSNKPLDRSQVPQSYKGN 1496
            |||||||||||.||||||::||||::|.:|..|..||..|:..:   |.|    |..:||.|.|.
Mouse   864 AKRLESLGALTHGDRRATESRDLSKYNFENKYGARALSRVLATIMGQTDN----RVPLPQGYPGG 924

  Fly  1497 ---FIYDCCVAMAGVGMINVREENKVKVFTVEKDSNNISKFLNRILGCRVEVQNALFKFFLDKMY 1558
               |..|....:..||:.:  .|::.....||||. :|:||||||||..|..|||||::|.|...
Mouse   925 DTAFFRDMKQGLLSVGIGS--RESRSGCLDVEKDC-SITKFLNRILGLEVHKQNALFQYFSDTFD 986

  Fly  1559 SLIMQMKRTGRFDLGILDLDAHGASVKSIKLMRFIRK-HATGTAATELHTVTVERGMSFETALAK 1622
            .||...|:.||:|:|||||......:.......|:.. |...........::|:|||.:|.||.:
Mouse   987 HLIEIDKKEGRYDMGILDLAPGINEIHEESQQVFLAPGHPQDGQVVFYKQISVDRGMKWEEALTR 1051

  Fly  1623 -YRKEGQYEHEGFYILQKRRQNKNSAILCLQAPSNSSDVSNGKINLQIYRPNTGPQVRLETHASI 1686
             ...:|.|  :|||:..|.|.:|.|   ||.|..|..:.      ..:|:||.|.|.:|||..|:
Mouse  1052 SLELKGPY--DGFYLSYKVRGSKMS---CLLAEQNRGEY------FTVYKPNIGRQSQLETLDSL 1105

  Fly  1687 SSRYVKVSPEEAQTYWVQQYELCLNMCSHLYWNRTCPMPTG---CEVGLRMRTYHVLSGLMLPIW 1748
            ..::.:|:.|||:..|...|.|.|..|||..||:.|.:...   |..|||:|.:::|.|.:|.:|
Mouse  1106 CRKFHRVTVEEAREPWESSYALSLEHCSHTTWNQRCRLTQEGKCCAQGLRLRHHYMLCGALLRVW 1170

  Fly  1749 DRIELII--VNSGHKIQIIRMKTDANKKIVGTVVPPAVYDDLVADL 1792
            .||..::  |:|...:||:|:||...||.||..:|......::.:|
Mouse  1171 GRIAAVMADVSSSSYLQIVRLKTKDKKKQVGIKIPEGCVHRVLQEL 1216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3491	NP_609731.1	AAA_34	737..1038	CDD:290583	190/300 (63%)
		DEXDc	759..986	CDD:214692	141/226 (62%)
		Helicase_C_4	1297..1576	CDD:290582	166/284 (58%)
Sbno2	NP_906271.1	Helicase_C_4	726..1004	CDD:372771	166/284 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1319..1349
		PARM	<34..>165	CDD:374970	28/154 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..212		18/42 (43%)
		AAA_34	212..500	CDD:372772	191/301 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	609..633		6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848482
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6217
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112455at33208
OrthoFinder	1	1.000	-	-		FOG0002373
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102140
Panther	1	1.100	-	-	O	PTHR12706
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1569
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.660