DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3491 and sbno1

DIOPT Version :9

Sequence 1:	NP_609731.1	Gene:	CG3491 / 34870	FlyBaseID:	FBgn0028887	Length:	1801	Species:	Drosophila melanogaster
Sequence 2:	XP_017945924.1	Gene:	sbno1 / 100170149	XenbaseID:	XB-GENE-479411	Length:	1410	Species:	Xenopus tropicalis

Alignment Length:	1421	Identity:	632/1421 - (44%)
Similarity:	848/1421 - (59%)	Gaps:	179/1421 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   499 ESDIDARLQAELDSLPM-VAVPADENIEPLGKTDQHFSVPTNKNLSENKAFPKPNQVCIPPQPAI 562
            ||.|.|....:.|||.: :..|.     ||....|..|:..:....||:|      ..:..:|..
Frog    15 ESGISANDLFDGDSLDIGLIAPT-----PLPAIQQAVSISGSGISKENEA------SVLKQEPLA 68

  Fly   563 PPQPAI----PPAPAYCMANK--TMDTGMSSVVQMANNPLASTQHHALPQVPIVTRLKVDQGEDV 621
            ....|:    ||:....:.|:  .:.|..:::|...|.|:.:|:     |...||::
Frog    69 TSASALLNVRPPSTTTFVLNQINQLPTLGNTIVMTKNTPVTTTR-----QTITVTKI-------- 120

  Fly   622 SVKFTTGLDGLITNVQLLPSTMAMGQPTVKAT--ELESFTAQQLNMLLQSG--HPYLSL-PMTNS 681
                      |.||....|||.|   |.|:.|  .:.|....||..||::.  :..:.| |.:|.
Frog   121 ----------LQTNSTTRPSTAA---PVVQTTVAAVPSKDQIQLKDLLKTSSLNKLMKLKPPSNI 172

  Fly   682 GVPGAVLQETL--------QTKDAGFPS--------------------------------EQAVE 706
            ..|.|...:.|        .||.|..|:                                ::..|
Frog   173 AQPVATAAKFLILSPKVVCPTKSADLPNGAKKDISKEVTRIWINEDIKMRSFSPTNKVPVKEDEE 237

  Fly   707 DEEVDYEEIGVADTFAAYWPSKLKFGRAHPDPVVETATLSSVELPNINYQLALPSKTTE--CLSA 769
            .||.|.:|:|.|:|:|.|.|.|||.|..||||||||::||||..|::.:|..:|.:|.:  .|||
Frog   238 PEEEDEDEMGHAETYAEYMPIKLKVGLRHPDPVVETSSLSSVTPPDVWFQTTIPEETIDNGWLSA 302

  Fly   770 LQLEAVVYACQAHEQILPSGDRAGFLLGDGAGVGKGRTIAGIIFDNYLKGRKRALWVSVSSDLKF 834
            ||||||.||.|.||..||:|:|||||:|||||||||||||||||:|||..|||:||.|||:|||:
Frog   303 LQLEAVTYAAQQHETFLPNGERAGFLIGDGAGVGKGRTIAGIIFENYLLSRKRSLWFSVSNDLKY 367

  Fly   835 DAERDLADIGAHEKIRVATINKFKYSPIDSEENENFKRGVIFCTYTALIGESMTTNSKYKTRFRQ 899
            ||||||.|||| :.|:|.::|||||..|.|:.|.:.|:||||.||::|||||. :..|||||.:|
Frog   368 DAERDLRDIGA-KNIQVHSLNKFKYGKISSKHNGSVKKGVIFATYSSLIGESQ-SGGKYKTRLKQ 430

  Fly   900 LTNWLGKKFEGVIVFDECHKAKNLSLMNVGKSTKTGTTVLDLQKLLPNARVVYASATGASEPRNM 964
            |.:|.|:.|:||||||||||||||..:...|.||||..||:||..||.|||||||||||||||||
Frog   431 LLHWCGEDFDGVIVFDECHKAKNLCPVGSSKPTKTGLAVLELQNKLPKARVVYASATGASEPRNM 495

  Fly   965 AYMVRLGLWGPGTAYPEFYEFVNAVEKRGIGAMEIVAMDMKLRGTYIARQLSFKDVSFRIEEVNM 1029
            |||.|||:||.||.:.||.:|:.|||:||:||||||||||||||.||||||||..|:|:||||.:
Frog   496 AYMSRLGIWGEGTPFREFNDFIQAVERRGVGAMEIVAMDMKLRGMYIARQLSFTGVTFKIEEVPL 560

  Fly  1030 SKEFRKSYNLSAELWADIHKKFQKACRLMCVENRVQKIITCQFWCAHQRFFKNLCIASKVNHVVK 1094
            ..::.|.||.|.:||....::||:|..|:..|.|::|.:..|||.|||||||.|||||||..||:
Frog   561 GHDYVKMYNKSVKLWVLARERFQQAADLIDAEQRMKKSMWGQFWSAHQRFFKYLCIASKVRRVVQ 625

  Fly  1095 MTRQATRMGKAVVIGLQSTGESRTLEHLERHHGKLNSFVSTAKMIIQSFVEKHFPAPKRDSFHHL 1159
            :.|:..:.||.||||||||||:||||.||...|:||.|||||:.::||.:|||||||.|.....|
Frog   626 LAREEIKNGKCVVIGLQSTGEARTLEALEEGGGELNDFVSTARGVLQSLIEKHFPAPDRKKLFSL 690

  Fly  1160 L----------NTGEFEPEARSRPPKQK------------KSKMNTDWVEDDMDAEAGESDIEMY 1202
            |          |:....|...|:..|:|            ||........|||.:|:..|:.:..
Frog   691 LGIDLSAQSNNNSPRDSPSKDSKVKKRKGEELLREAKKPRKSGGLAGSSSDDMGSESDTSEKDAG 755

  Fly  1203 ERSCTAAVEKIKSG---------------------------QKRRGRPPKADKVEKITMQERILE 1240
            ..|  .:.:.:.||                           :|.:.:..|...::..::|..:|.
Frog   756 SES--ESFKSVSSGDDDDFNPFRDESSEDEEDDPWLIRKDHKKNKHKKKKKKSIDPDSIQSALLA 818

  Fly  1241 HLCNNMREQDNE-------DESTNTS-----DNTKVKVN-ITERD-VERCINMREMLLEKIDVLG 1291
            ....:.|...:.       ..:|.||     :||.|..: :|.:| |||...|::.||:|::.|.
Frog   819 SGLGSKRPSFSSVVKAAATSTTTTTSVPAPLNNTNVSNSCVTSQDAVERAQQMKKELLDKLENLA 883

  Fly  1292 RKLPPNTLDKLISELGGTNLVAEMTGRRGRVVRTEYDGYKYEPRCENDSTMDLVNYREKQRFMDG 1356
            ..|||||||:||.||||.:.|||||||:||||..:.....||.|.|.|..::::|..||||||||
Frog   884 EALPPNTLDELIDELGGPDNVAEMTGRKGRVVSNDDGSISYESRSELDVPVEILNITEKQRFMDG 948

  Fly  1357 SKHVAIISEAASSGISLQSDKRVSNQRRRLHITLELPWSADRAIQQFGRTHRSNQVNAPEYVFVI 1421
            .|::||||||||||||||:|:|..|||||:|:||||||||||||||||||||||||.||||||:|
Frog   949 EKNIAIISEAASSGISLQADRRAKNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVTAPEYVFLI 1013

  Fly  1422 TDLAGERRFASTVAKRLESLGALTQGDRRATDARDLSQFNIDNSIGRSALENVMQQLTSNKPLDR 1486
            ::||||:||||.||||||||||||.||||||::||||:||.||..||:|||.||:.:.|   ||.
Frog  1014 SELAGEQRFASIVAKRLESLGALTHGDRRATESRDLSRFNFDNKYGRNALEIVMKSIVS---LDS 1075

  Fly  1487 SQV--PQSYKGNFIYDCCVAMAGVGMINVREENKVKVFTVEKDSNNISKFLNRILGCRVEVQNAL 1549
            ..|  |..:.|:|..|....:.|||:|||  |::..:.|::||.|||.||||||||..|..||||
Frog  1076 PLVSPPPEFPGDFFKDVRQGLIGVGLINV--EDRSGILTLDKDYNNIGKFLNRILGMEVHQQNAL 1138

  Fly  1550 FKFFLDKMYSLIMQMKRTGRFDLGILDLDAHGASVKSIKLMRFIRKHATGTAATELHTVTVERGM 1614
            |::|.|.:.::|...|:.||:|:|||||.:....|:.....:|:....:.:...||:|::|||||
Frog  1139 FQYFSDTLSAVIQNAKKNGRYDMGILDLGSGDEKVRKSDAKKFLTPGYSTSGHVELYTISVERGM 1203

  Fly  1615 SFETALAKYRKEGQYEHEGFYILQKRRQNKNSAILCLQAPSNSSDVSNGKINLQIYRPNTGPQVR 1679
            |:|.| .|...|.....:|||:..:.|.||.:.||.       .:::..|....:||||||.|::
Frog  1204 SWEDA-TKIWAEQTGPDDGFYLSLQIRNNKKTGILV-------KEINPKKKLFLVYRPNTGKQLK 1260

  Fly  1680 LETHASISSRYVKVSPEEAQTYWVQQYELCLNMCSHLYWNRTC---PMPTGCEVGLRMRTYHVLS 1741
            |||...:..:|.||:.|:||::|.:||....::|:|.||...|   .:...||:|||.|||:||.
Frog  1261 LETLLDLKKKYKKVTSEDAQSHWKEQYISSADICTHAYWRGNCKKASLGLVCEIGLRCRTYYVLC 1325

  Fly  1742 GLMLPIWDRIELIIVN-SGH--KIQIIRMKTDANKKIVGTVVPPAVYDDLVADLST 1794
            |.:|.:|.::|.::.: ||.  |:||:|::|:..::|||.::|......||..|||
Frog  1326 GSVLSVWTKVEGVLASVSGTNVKMQIVRLRTEDGQRIVGLIIPANCVSSLVTLLST 1381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3491	NP_609731.1	AAA_34	737..1038	CDD:290583	198/302 (66%)
		DEXDc	759..986	CDD:214692	151/228 (66%)
		Helicase_C_4	1297..1576	CDD:290582	174/280 (62%)
sbno1	XP_017945924.1	AAA_34	268..570	CDD:372772	199/303 (66%)
sbno1	XP_017945924.1	Helicase_C_4	889..1165	CDD:372771	174/280 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112455at33208
OrthoFinder	1	1.000	-	-		FOG0002373
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12706
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1569
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020