DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3491 and sbno1

DIOPT Version :9

Sequence 1:	NP_609731.1	Gene:	CG3491 / 34870	FlyBaseID:	FBgn0028887	Length:	1801	Species:	Drosophila melanogaster
Sequence 2:	NP_001186845.1	Gene:	sbno1 / 100005813	ZFINID:	ZDB-GENE-080522-2	Length:	1386	Species:	Danio rerio

Alignment Length:	1414	Identity:	619/1414 - (43%)
Similarity:	827/1414 - (58%)	Gaps:	200/1414 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   501 DIDARLQAELDSLPMVA--VPADENIEPLGKTDQHFSVPTNKNLSENKAFPKPNQVCIPPQPAIP 563
            |:|.:     ||:|:|:  .|...|...:|.:::...|                         :.
Zfish    24 DVDVQ-----DSVPLVSSQQPVSLNALDIGLSNEASGV-------------------------VR 58

  Fly   564 PQPAIPPAPAYCMANKTMDTGMSSVVQMANNPLASTQHHALPQVPIVTRLKVDQGEDVSVKFTTG 628
            ..|.:||.|...:..|...:..:.|:...|.         ||.:..:...|...|.......|
Zfish    59 IDPPVPPTPTVTIREKPQPSTTTFVLNQLNQ---------LPSLGTIVVSKPSTGSSTRQTIT-- 112

  Fly   629 LDGLITNV--QLLPSTMAMGQPTVKATELESFTAQ-QLNMLLQS--------GHPYLSLPMTNSG 682
                :|.|  ...|:..:...|:| .|...:.|.| :|..||:|        |......|..:..
Zfish   113 ----VTKVLHSSSPAQRSSASPSV-CTAAPANTEQIRLKDLLRSSSLKSSSLGELMKLKPPADIA 172

  Fly   683 VPGAV----------LQETLQTKDA---------------------GFPSEQAVEDEEVDYEEIG 716
            .|.|.          |::.:.:||.                     |...|:  |.||.:.||:|
Zfish   173 PPVATATGTTEVNNGLKKEVSSKDVARIWINDDMKMRSFSPVNKLPGMKEEE--EPEEEEEEELG 235

  Fly   717 VADTFAAYWPSKLKFGRAHPDPVVETATLSSVELPNINYQLALPSKTTE--CLSALQLEAVVYAC 779
            .|:|:|.|.|.|.:.|..||||||||::||||..|::.|:|::|.:|.:  .|||||||||.||.
Zfish   236 HAETYAEYMPMKQRIGLRHPDPVVETSSLSSVNPPDVWYRLSIPEETIDRGWLSALQLEAVTYAA 300

  Fly   780 QAHEQILPSGDRAGFLLGDGAGVGKGRTIAGIIFDNYLKGRKRALWVSVSSDLKFDAERDLADIG 844
            |.||..||:||||.:|:||||||||||||||||::|||.||||:||.|||:|||:||||||.|||
Zfish   301 QQHETFLPNGDRAAYLIGDGAGVGKGRTIAGIIYENYLLGRKRSLWFSVSNDLKYDAERDLRDIG 365

  Fly   845 AHEKIRVATINKFKYSPIDSEENENFKRGVIFCTYTALIGESMTTNSKYKTRFRQLTNWLGKKFE 909
            | :.|:|.::|||||..|.|:.|.:.|:||||.||::|||||. :..||||||:||.:|.|..|:
Zfish   366 A-KNIQVHSLNKFKYGKISSKHNGSVKKGVIFATYSSLIGESQ-SGGKYKTRFKQLLHWCGDDFD 428

  Fly   910 GVIVFDECHKAKNLSLMNVGKSTKTGTTVLDLQKLLPNARVVYASATGASEPRNMAYMVRLGLWG 974
            |||||||||||||:..:...|.||||..||:||..||.||||||||||||||||||||.|||:||
Zfish   429 GVIVFDECHKAKNVCPIGSSKPTKTGLAVLELQNKLPKARVVYASATGASEPRNMAYMNRLGIWG 493

  Fly   975 PGTAYPEFYEFVNAVEKRGIGAMEIVAMDMKLRGTYIARQLSFKDVSFRIEEVNMSKEFRKSYNL 1039
            .||.:.||..|:.|||:||:||||||||||||||.||||||||..|:|:||||.::.::.|.||.
Zfish   494 EGTPFREFANFIQAVERRGVGAMEIVAMDMKLRGMYIARQLSFTGVTFKIEEVPLTLDYIKMYNK 558

  Fly  1040 SAELWADIHKKFQKACRLMCVENRVQKIITCQFWCAHQRFFKNLCIASKVNHVVKMTRQATRMGK 1104
            :..||....:|||:|.:||..|.|::|.:..|||.|||||||.|||||||..||::.|:..:.||
Zfish   559 AVRLWVSAREKFQQAAQLMDAEQRMKKSMWGQFWSAHQRFFKYLCIASKVRRVVQLAREDVKNGK 623

  Fly  1105 AVVIGLQSTGESRTLEHLERHHGKLNSFVSTAKMIIQSFVEKHFPAPKRDSFHHLL--------- 1160
            .||||||||||:||||.||...|:||.||||||.::||.||||||||.|.....||
Zfish   624 CVVIGLQSTGEARTLEALEEGGGELNDFVSTAKGVLQSLVEKHFPAPDRQKLLSLLGIDLSAKKT 688

  Fly  1161 -----NTGEFE------PEARSRPPKQKKSKMNTDWVEDDMDAEAGESDIEMYERSCTAAVEKIK 1214
                 |..|.:      ||::....|.:||...:....||..:|..:.|.|..:     :.:.|.
Zfish   689 PSPAENKTEQKGKKRKVPESKKHVKKARKSGGLSGSSSDDSSSEDSDRDAESDD-----SFKSIS 748

  Fly  1215 SGQKRRGRPPKAD-----------------------------KVEKITMQERILEHLCNNMR--- 1247
            ||.:....|.|.|                             .::..::|..:|.......|
Zfish   749 SGDEDDFNPFKDDSSEDEEDDPWLIRKDSKKSKDKRNKKKKKSIDPDSIQSALLASGLGTTRPTF 813

  Fly  1248 --------------EQDNEDESTNTSDNTKVKVNITERDVERCINMREMLLEKIDVLGRKLPPNT 1298
                          :.|.|:.|..||.:.          ||....|:..||||:::|...|||||
Zfish   814 TAPIKPANPTLAVAKSDPEESSCVTSQDA----------VEDAQRMKRDLLEKLELLAEDLPPNT 868

  Fly  1299 LDKLISELGGTNLVAEMTGRRGRVVRTEYDGYKYEPRCENDSTMDLVNYREKQRFMDGSKHVAII 1363
            ||:||.||||.:.|||||||:||||..:.....||.|.|.|..::::|..|||.||||.|::|||
Zfish   869 LDQLIDELGGPDNVAEMTGRKGRVVSNDDGSISYESRSELDVPVEILNLTEKQTFMDGDKNIAII 933

  Fly  1364 SEAASSGISLQSDKRVSNQRRRLHITLELPWSADRAIQQFGRTHRSNQVNAPEYVFVITDLAGER 1428
            |||||||||||:|:||.|||||:|:||||||||||||||||||||||||.||||||:|::||||:
Zfish   934 SEAASSGISLQADRRVKNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVTAPEYVFLISELAGEQ 998

  Fly  1429 RFASTVAKRLESLGALTQGDRRATDARDLSQFNIDNSIGRSALENVMQQLTSNKPLDRSQV--PQ 1491
            ||||.||:|||||||||.||||||:.||||:||.||..||:|||.||:.:.|   ||...|  |.
Zfish   999 RFASIVAQRLESLGALTHGDRRATETRDLSRFNFDNKYGRNALEIVMKSIVS---LDSPLVSPPA 1060

  Fly  1492 SYKGNFIYDCCVAMAGVGMINVREENKVKVFTVEKDSNNISKFLNRILGCRVEVQNALFKFFLDK 1556
            .:.|:|..:....:.|||:|||  |::..|.:::||.|||.||||||||..|:.|||||::|.|.
Zfish  1061 DFDGDFFKEIRNGLIGVGLINV--EDRSGVLSLDKDYNNIGKFLNRILGMEVQQQNALFQYFSDT 1123

  Fly  1557 MYSLIMQMKRTGRFDLGILDLDAHGASVKSIKLMRFIRKHATGTAATELHTVTVERGMSFETALA 1621
            :.::|...|::||:|:|||||.:....||.:.:.:|:....:.:...||:||:||||||:|.|..
Zfish  1124 LSAVIQNAKKSGRYDMGILDLGSGDEKVKKVDVKKFLTPGYSTSGHVELYTVSVERGMSWEEATH 1188

  Fly  1622 KYRKEGQYEHEGFYILQKRRQNKNSAILCLQAPSNSSDVSNGKINLQIYRPNTGPQVRLETHASI 1686
            .:..:...: :|||:  :.|.||..|||.       .:|:..|....:||||.|.|.:|||:..|
Zfish  1189 VWADQNGPD-DGFYV--QVRNNKKIAILV-------KEVNPRKRLFMVYRPNIGKQAKLETYTDI 1243

  Fly  1687 SSRYVKVSPEEAQTYWVQQYELCLNMCSHLYWNRTCPMPT---GCEVGLRMRTYHVLSGLMLPIW 1748
            ..|..||..::|:.:|:.||....::|||.||...|...:   .||:|||.|||.||.|.:|.:|
Zfish  1244 KKRSKKVLSDDAKQHWMDQYSCSADVCSHAYWRGNCKKASVGLQCEIGLRCRTYFVLCGSVLSVW 1308

  Fly  1749 DRIELIIVN-SGH--KIQIIRMKTDANKKIVGTVVPPAVYDDLVADLST 1794
            .::|.::.: ||.  |:||:|::|:..::|||.::|......||..||:
Zfish  1309 TKVEGVLASVSGANVKMQIVRLRTEDGQRIVGLIIPQNCVSPLVNILSS 1357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3491	NP_609731.1	AAA_34	737..1038	CDD:290583	198/302 (66%)
		DEXDc	759..986	CDD:214692	150/228 (66%)
		Helicase_C_4	1297..1576	CDD:290582	172/280 (61%)
sbno1	NP_001186845.1	AAA_34	256..558	CDD:290583	199/303 (66%)
sbno1	NP_001186845.1	Helicase_C_4	867..1143	CDD:290582	172/280 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4495
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112455at33208
OrthoFinder	1	1.000	-	-		FOG0002373
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102140
Panther	1	1.100	-	-	O	PTHR12706
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1569
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920