Protein Alignment GEN1 and Gen

DIOPT Version :10

• Sequence 1: NP_872431.5
• Gene: GEN1 / 348654
• HGNCID: 26881
• Length: 908
• Species: Homo sapiens
• Sequence 2: NP_647943.2
• Gene: Gen / 38594
• FlyBaseID: FBgn0263831
• Length: 726
• Species: Drosophila melanogaster
• Alignment Length: 740
• Identity: 213/740 - (28%)
• Similarity: 346/740 - (46%)
• Gaps: 101/740 - (13%)

Human     1 MGVNDLWQILEPVKQHIPLRNLGGKTIAVDLSLWVCEAQTVKKMMGSVMKP--HLRNLFFRISYL 63
            |||.:||.:|.|..:..|:..|.||.:|:||:.||||:..|   :...:.|  ||:|||||..||
  Fly     1 MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWVCESLNV---VDYFVHPRHHLKNLFFRTCYL 62

Human    64 TQMDVKLVFVMEGEPPKLKADVISKRNQSRY-GSSGKSWSQKT---------GRSHFKSVLRECL 118
            ....|..|||:||..||||:.||:|||:.:: |...|:..:.|         |||.|..||::|.
  Fly    63 IWEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSKGDKGRSRFNHVLKQCE 127

Human   119 HMLECLGIPWVQAAGEAEAMCAYLNAGGHVDGCLTNDGDTFLYGAQTVYRNFTMNTKDPH----- 178
            .:|..:||..||..|||||.||:||..|.|||.::.|.|.|.|||..|||||:::|:...
  Fly   128 TLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRVYRNFSVSTQGAQAAAGG 192

Human   179 -VDCYTMSSIKSKLGLDRDALVGLAILLGCDYLPKGVPGVGKEQALKLIQILKGQSLLQRFNRW- 241
             ||.|.|..|.|::...:..::.:|:|.||||.|.|:.|:||:..|||....|...:|.|...|
  Fly   193 AVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGKDGVLKLFNKYKETEILDRMRSWR 257

Human   242 NETSCNSSPQLLVTKKLAHCSVCSHPGSPKDHERNGCRLCKSDKYCEPHDYEYCCPCEWHRTEHD 306
            .||...::.::.|..| :.||.|.|.|..:.|.::||.:|::.|.|:...::            :
  Fly   258 GETDKYNALEIRVDDK-SICSNCGHIGKTQSHTKSGCSVCRTHKGCDESLWK------------E 309

Human   307 RQLS-EVENNIKKKACCCEGFPFHEVIQEFLLNKDKLVKV-IRYQRPDLLLFQRFTLEKMEWPNH 369
            ::|| :.|..:::||.....||..|:|.|||...|.:..: :.:::|:|:.|.:.....::||..
  Fly   310 QRLSIKSELTLRRKALLSPDFPNEEIIAEFLSEPDTIPNLNLNWRQPNLVKFIKQIGHLLQWPEI 374

Human   370 YACEKLLVLLTHYDMIERKLGSRNSNQLQPIRIVKTRIRNGVHCFEIEWEKPEHY---AMEDKQH 431
            |..:|...:||.:.:.:.|   :....:||..|:|.|...||...|:.|..|...   .:.|||.
  Fly   375 YCFQKFFPILTRWQVQQSK---QEKILIQPHEIIKKRTVKGVPSLELRWHDPSGIFKGLIPDKQI 436

Human   432 GEF----------ALLTIEEESLFEAAYPEIVAVYQKQKLEIKGK---KQKRIKPKENNLPEPDE 483
            .|:          ...|||...:.|.|||::||.:.|.|.:...|   |:|....:||...||:
  Fly   437 AEYEAEHPKGIEELYYTIEPLDMLETAYPDLVAAFLKSKEKPAKKTTRKKKTASEEENKENEPN- 500

Human   484 VMSFQSHMTLKPTCE------IFHKQNSKLNSGISPDPTLPQESISASLNSLLLPKN--TPCLNA 540
              |....:..|...:      :.|:...:...|.......||....::..:..||.:  :.| :|
  Fly   501 --SKPKRVVRKIKAQPEENQPLLHQFLGRKKEGTPVKAPAPQRQQCSTPITKFLPSDLESDC-DA 562

Human   541 QEQFMSSLRPLAIQQIKAVSKSLISESSQPNTSSHNI---SVIADLHLSTIDWEGTSFSNSPAIQ 602
            :|..||.:       :|.:..:..::.:..|...|.:   .:..||.|........:.:.||.::
  Fly   563 EEFDMSDI-------VKGIISNPNAKPALTNHDGHQLHYEPMAEDLSLRLAQMSLGNVNESPKVE 620

Human   603 RNTFSHDLKSEVESELSAIPDGFE-----NIPEQLSCESERYTA----------------NIKKV 646
            .......:....:|:..::.|.|:     ::.:......||:..                ||...
  Fly   621 TKRDLSQVDQLPQSKRFSLEDSFDLLVKGDLQKLARTPVERFKMQHRISEKIPTPVKPLDNISYF 685

Human   647 LDEDSDGISPEEHLLSGITDLCLQD 671
            .::.||.....|.|::  :.|..||
  Fly   686 FNQSSDNADVFEELMN--SSLVPQD 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEN1	NP_872431.5	PIN_GEN1	2..206	CDD:350217	91/221 (41%)
		XPG-N domain. /evidence=ECO:0000269|PubMed:26682650	2..96		43/96 (45%)
		XPG-I domain. /evidence=ECO:0000269|PubMed:26682650	122..208		38/91 (42%)
		H3TH_GEN1	195..338	CDD:188625	45/144 (31%)
		5'-3' exonuclease domain. /evidence=ECO:0000269|PubMed:26682650	208..384		51/178 (29%)
		Chromodomain. /evidence=ECO:0000269|PubMed:26682650	390..464		25/86 (29%)
		Chromo_2	398..458	CDD:465841	23/72 (32%)
Gen	NP_647943.2	PIN_GEN1	2..207	CDD:350217	89/207 (43%)
		H3TH_GEN1	210..342	CDD:188625	45/144 (31%)
		Chromo_2	400..473	CDD:465841	23/72 (32%)