DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15279 and Slc6a2

DIOPT Version :9

Sequence 1:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_112633.2	Gene:	Slc6a2 / 83511	RGDID:	621822	Length:	617	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	202/571 - (35%)
Similarity:	320/571 - (56%)	Gaps:	32/571 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SDDQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIVLFLIGKP 102
            |.|.:|    :.|.||||.::||:|.:..:|.|.||||||:....||||||||||.:.|.:.|.|
  Rat    48 SQDGDA----QPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMP 108

  Fly   103 IYYLEMVIGQFSSRGSVKVFDLCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYFIESFRNPLPW 167
            ::|:|:.:|||:..|:..|:.:||..||||.........:..||..::|....|...||...|||
  Rat   109 LFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPW 173

  Fly   168 STCRAEWGI-HCINSAPDASNWSQLESNDQRPQNYTMKSQNDRVITSSEWYFVKEV--LHEKPNI 229
            :.|...|.. :|.:  |...|.|.|       .::|..|:..  .|.:..::.:.|  |||...|
  Rat   174 TNCGHAWNSPNCTD--PKLLNASVL-------GDHTKYSKYK--FTPAAEFYERGVLHLHESSGI 227

  Fly   230 EEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRAVTLPGSIDGI 294
            .: ||||.|:|::.|.:....::|.:.:|||:|||..:..|..||.::.||||..|||||:.:||
  Rat   228 HD-IGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGI 291

  Fly   295 YYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIVTGLDTMTSLL 359
            ..::...:.::.:..||..|.||.|:||...||.:|.::|:|||.:|.:|||.:.:.::.:||.:
  Rat   292 NAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFI 356

  Fly   360 AGFTIFGILGHLAHE--IGTDDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFSVLFFLMLFVLGI 422
            :||.||.|||::|||  :..:|:.:   .||||.|:.||:||:.... ...::|||||||..||:
  Rat   357 SGFAIFSILGYMAHEHKVKIEDVAT---EGAGLVFVLYPEAISTLSG-STFWAVLFFLMLLALGL 417

  Fly   423 GSNIAMTSCSVTAIRDRFPNFGQ----WQCSLLIAVVSFFIGLMYITPGGQYMLTLVDFFGASMI 483
            .|::......:|.:.|.|....:    :.|::.:.  :|.:.:..||.||.|:|||:|.|.|...
  Rat   418 DSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLG--TFLLAMFCITKGGIYVLTLLDTFAAGTS 480

  Fly   484 ALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIYFYATYQPLTY 548
            .|...:.|...:.|.||.||...||:.|:|.|.||||||||..::|..:..:::.....::||||
  Rat   481 ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTY 545

  Fly   549 NNIVYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPK 599
            ::.|||.|:..:||.|....::.:|.::|.......| :|..::....||:
  Rat   546 DDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRG-SLWERVAYGITPE 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	197/556 (35%)
Slc6a2	NP_112633.2	SLC5-6-like_sbd	56..615	CDD:382020	199/559 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820