DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15279 and slc6a3

DIOPT Version :9

Sequence 1:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_571830.1	Gene:	slc6a3 / 80787	ZFINID:	ZDB-GENE-010316-1	Length:	629	Species:	Danio rerio

Alignment Length:	627	Identity:	218/627 - (34%)
Similarity:	341/627 - (54%)	Gaps:	62/627 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TTQRNHQNLAFVGDDGRSTAS---TVEI--------------STNSPALRDNSDDQ-EAAKVPEE 49
            |..|.|.:::.|  .|.|:|:   .||:              |..:|....::... ......::
Zfish    13 TRTRTHTHMSSV--SGSSSAAGPREVELVLVKEQNGVQFTSSSLRNPGAHSHTHTHTHTHPSGQQ 75

  Fly    50 RATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIVLFLIGKPIYYLEMVIGQFS 114
            |.||||.::||:|.|..:|.|.||||||:....|||||||:|||:.:.:.|.|::|:|:.:||::
Zfish    76 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQYN 140

  Fly   115 SRGSVKVFDLCPAMKGVGAGQAFQVFMLS----TYYAALVAIIGRYFIESFRNPLPWSTCRAEWG 175
            ..|:..|:.:||..||||    |.|.::|    :||..::|....|...||...|||
Zfish   141 REGAAGVWKICPIFKGVG----FTVILISLYVGSYYNVIIAWALFYLFSSFSGELPW-------- 193

  Fly   176 IHCINSAPDASNWSQLESNDQRPQNYTMKSQNDRVITSSEWYFVKEVL--HEKPNIEEGIGLPNW 238
            |||.|:      |:....:|   .|.|:.:...:...:.| ||.:.||  ||...|:: :|.|.|
Zfish   194 IHCNNT------WNSPNCSD---PNATLLNDTYKTTPALE-YFERGVLHVHESSGIDD-LGAPRW 247

  Fly   239 ELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRAVTLPGSIDGIYYFIKPQWG 303
            :|...|.:....::|.:.:|||:|||..:..|..|||::.|||:|.|||||:||||..::...:.
Zfish   248 QLTACLAVVIVVLYFSLWKGVKTSGKVVWITATMPYVVLTVLLLRGVTLPGAIDGIKAYLSVDFL 312

  Fly   304 KILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIVTGLDTMTSLLAGFTIFGIL 368
            ::.|.:||..|.||..:||.|.||.:|.:||:|||.:|.:|||.|.:.::::||..:||.||..|
Zfish   313 RLYDAQVWIEAATQICFSLGVGFGVLIAFSSYNKFSNNCYRDAIITSSINSLTSFFSGFVIFSFL 377

  Fly   369 GHLA--HEIGTDDIGSVVKGGAGLAFISYPDAIAKFKNLP--QIFSVLFFLMLFVLGIGSNIAMT 429
            |:::  |.:..|   .|...|.||.||.||:|||   .||  .:::|:||:||..|||.|.:...
Zfish   378 GYMSQKHNVALD---KVATDGPGLVFIIYPEAIA---TLPGSSVWAVIFFIMLLTLGIDSAMGGM 436

  Fly   430 SCSVTAIRDRFPNFGQWQ--CSLLIAVVSFFIGLMYITPGGQYMLTLVDFFGASMIALVLGIAEL 492
            ...:|.:.|.|....:.:  .:|.|.|.:|.|.|:.:|.||.|:.||:|.|.|....|...:.|.
Zfish   437 ESVITGLIDEFKFLHKHRELFTLFIVVSTFLISLICVTNGGIYVFTLLDHFAAGTSILFGVLIEA 501

  Fly   493 YTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIYFYATYQPLTYNNIVYPNWS 557
            ..|.|.||.||...|||.|:|::.||||||||..::|..:..:::..:||:.|..|.:..:|.|:
Zfish   502 IGIAWFYGVDRFSDDIEEMIGQRPGLYWRLCWKFVSPCFLLFMVVVSFATFNPPKYGSYYFPTWA 566

  Fly   558 YSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPK 599
            ..:||.::...::.:|::........|| :...|:..|.||:
Zfish   567 TMVGWCLSISSMIMVPLYAFYKFCSLPG-SFCDKLAYAITPE 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	205/559 (37%)
slc6a3	NP_571830.1	SLC6sbd_DAT1	76..623	CDD:212083	207/562 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820