DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15279 and slc6a17

DIOPT Version :9

Sequence 1:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001243653.1	Gene:	slc6a17 / 798635	ZFINID:	ZDB-GENE-030131-8187	Length:	730	Species:	Danio rerio

Alignment Length:	713	Identity:	215/713 - (30%)
Similarity:	335/713 - (46%)	Gaps:	151/713 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TQRNHQN---LAFVGD--------DGRSTASTVEISTNS-PAL--RDNSDDQEAAKVPEERATWG 54
            |||.|.|   ...|.|        |.:|:..::.::..| |.:  .|.|.|.|     :.|..|.
Zfish     8 TQREHSNEPVTESVADLLALEAPMDYKSSQMSMNMTGGSAPPIGKPDISPDLE-----DGRPAWN 67

  Fly    55 KGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIVLFLIGKPIYYLEMVIGQFSSRGSV 119
            ..::::::.:..|||||||||||:....|||||:|:||.|:|.|||.|:::||:.:||...|||:
Zfish    68 SKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLVPYFILLILIGIPLFFLELAVGQRIRRGSI 132

  Fly   120 KVFD-LCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYFIESFRNPLPWSTCRAEWGIHCINSAP 183
            .|:: :||.:.|:||........:..||..::.....||.:||:.|||||.|            |
Zfish   133 GVWNYVCPRLGGIGASSLMVCGFVGLYYNVIIGWSIFYFFQSFQYPLPWSDC------------P 185

  Fly   184 DASNWSQ--LESNDQRPQNYTMKSQNDRVITSSEWYFVKEVLHEKPNIEEGIGLPNWELVIGLFI 246
            ...|.||  :|...::..           .|:..||  :|.|:....|.:..|| ||.:.:.|..
Zfish   186 IRKNGSQAIVEPECEKSS-----------ATTYFWY--RETLNITSTIADSGGL-NWRMTLSLLA 236

  Fly   247 AWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRAVTLPGSIDGIYYFIKPQWGKILDPKVW 311
            ||..|...:.:|::||||..||.:|||||::...|||.:.|.|::|||.:...|:...:|:|:||
Zfish   237 AWIIVCLAVIKGIQSSGKVMYFSSLFPYVVLFCFLVRGLFLKGAVDGIAHMFTPKLEIMLEPQVW 301

  Fly   312 YAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIVTGLDTMTSLLAGFTIFGILGH------ 370
            ..|.||.|::|.:.||.:|.:||:||..:|.|.||.:|:.::.:||:||...:|.:||.
Zfish   302 REAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSVINFLTSILATLVVFAVLGFKANIMN 366

  Fly   371 -------------------LAHEI-------------------GT-------------------- 377
                               |:|::                   |.
Zfish   367 EKCVVENAEKILGYLNSNVLSHDLIPPHVNFSHLTTSDYAEMYGVIKIVKEDSFAQLGLEQCLLE 431

  Fly   378 DDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFSVLFFLMLFVLGIGSNIAMTSCSVTAIRDRFPN 442
            |::...|: |.|||||::.:|:..|...| .:||:||.||..||:||.|...:...|.|.|.| .
Zfish   432 DELNKAVQ-GTGLAFIAFTEAMTHFPASP-FWSVMFFFMLINLGLGSMIGTMTGITTPILDTF-K 493

  Fly   443 FGQWQCSLLIAVVSFFIGLMYITPGGQYMLTLVDFFGASMIALVLGIAELYTIGWIYGTDRLCKD 507
            ..:...::...:|:|..||:::...|.|.:|:.|.:.|.:...::.|.|..::.|||||.|..:|
Zfish   494 IRKEYLTVGCCIVAFLCGLLFVQRSGNYFVTMFDDYSAGLPLTIVVILENVSVAWIYGTKRFMQD 558

  Fly   508 IEFMLG-RKVGLYWRLCWSIITPLIMTVILI---YFYATYQPLTYNNIV----------YPNWSY 558
            :|.||| |...:|:.| |..::|:.: :|||   .......||.||..|          ||.|:.
Zfish   559 LEDMLGFRPYSVYFYL-WKYVSPVCL-IILISASVVEMAISPLGYNAWVQDLAMERFQSYPPWAI 621

  Fly   559 SIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPKKNWGP-SDPLLREQYHKEIENE 620
            .:.:.:....:|.||   :|.|.|                ..||.| ....|...|.|.:..|
Zfish   622 VMCFALIIVAMLPLP---LVFIAR----------------HFNWLPDGSNKLSVSYRKSLAKE 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	193/628 (31%)
slc6a17	NP_001243653.1	SLC5-6-like_sbd	63..651	CDD:294310	196/637 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920