Protein Alignment CG15279 and SLC6A12

DIOPT Version :10

• Sequence 1: NP_609726.1
• Gene: CG15279 / 34863
• FlyBaseID: FBgn0028886
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 216/598 - (36%)
• Similarity: 329/598 - (55%)
• Gaps: 56/598 - (9%)

  Fly    40 DQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIVLFLIGKPIY 104
            |||.....::|..|...:||::|.....:|||||||||:....||||||.|||.|..|:.|.|::
Human    26 DQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVF 90

  Fly   105 YLEMVIGQFSSRGSVKVF-DLCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYFIESFRNPLPWS 168
            :||:.:||::|:|||..: .:||..:|:|.........|:.||..::|....|...||.:.|||:
Human    91 FLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWT 155

  Fly   169 TCRAEWGI-HCINSAPDASNWSQLESNDQRP-QNYT---MKSQNDRV--ITSSEWYFVKEVLHEK 226
            ||...|.. ||    .|..|.|  .:....| :|:|   |:....||  |||.        :|:
Human   156 TCNNFWNTEHC----TDFLNHS--GAGTVTPFENFTSPVMEFWERRVLGITSG--------IHD- 205

  Fly   227 PNIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRAVTLPGSI 291
                  :|...|||.:.|.:||...:|.|.:||||:||..||.|.|||:::.:||:|.|||||:.
Human   206 ------LGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAY 264

  Fly   292 DGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIVTGLDTMT 356
            .||.|::||...::.||:||..|.||.|:|.::|.|.:....|:||:.:|.::|...:..|::.|
Human   265 QGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSAT 329

  Fly   357 SLLAGFTIFGILGHLAHEIGTDDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFSVLFFLMLFVLG 421
            |.:|||.:|.|||.::.|.|. .|..|.:.|.|||||::|.|:.... |.|::|.|||:||..||
Human   330 SFVAGFVVFSILGFMSQEQGV-PISEVAESGPGLAFIAFPKAVTMMP-LSQLWSCLFFIMLIFLG 392

  Fly   422 IGSNIAMTSCSVTAIRDRFP----NFGQWQCSLL-IAVVSFFIGLMYITPGGQYMLTLVDFFGAS 481
            :.|......|.|||..|.||    ..|:.:..:| |||:.:.|||..:|.||.|:..|.|::.:|
Human   393 LDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASS 457

  Fly   482 MIALV-LGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIYFYATYQP 545
            .|.|: |.:.|:..|.|:||.||...:||.|:|.:.....::.|..:||.:.....::..:.|.|
Human   458 GICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTP 522

  Fly   546 LTYNNI-VYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPK---------- 599
            |.|||: |||.|.|||||.:....::.:|:::::.:::..| ....::|...||.
Human   523 LKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRG-PFRKRLRQLITPDSSLPQPKQHP 586

  Fly   600 -------KNWGPS 605
                   :|:|||
Human   587 CLDGSAGRNFGPS 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:444915	207/562 (37%)
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	207/563 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		4/24 (17%)