Protein Alignment CG15279 and SLC6A3

DIOPT Version :9

• Sequence 1: NP_609726.1
• Gene: CG15279 / 34863
• FlyBaseID: FBgn0028886
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_001035.1
• Gene: SLC6A3 / 6531
• HGNCID: 11049
• Length: 620
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 210/594 - (35%)
• Similarity: 327/594 - (55%)
• Gaps: 49/594 - (8%)

  Fly    21 TASTVEISTNSPALRDNSDDQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGG 85
            |:||:.....||.        ||    ::|.||||.::||:|.|..:|.|.||||||:....|||
Human    43 TSSTLTNPRQSPV--------EA----QDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGG 95

  Fly    86 GAFLIPYLIVLFLIGKPIYYLEMVIGQFSSRGSVKVFDLCPAMKGVGAGQAFQVFMLSTY----Y 146
            ||||:|||:.:.:.|.|::|:|:.:|||:..|:..|:.:||.:||||    |.|.::|.|    |
Human    96 GAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVG----FTVILISLYVGFFY 156

  Fly   147 AALVAIIGRYFIESFRNPLPWSTCRAEWGIHCINSAPDASNWSQLESNDQRPQNYTMKSQ--NDR 209
            ..::|....|...||...|||        |||.||      |:....:|..|.:.:..|.  ||.
Human   157 NVIIAWALHYLFSSFTTELPW--------IHCNNS------WNSPNCSDAHPGDSSGDSSGLNDT 207

  Fly   210 V-ITSSEWYFVKEV--LHEKPNIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLAL 271
            . .|.:..||.:.|  ||:...|:: :|.|.|:|...|.:....::|.:.:|||:|||..:..|.
Human   208 FGTTPAAEYFERGVLHLHQSHGIDD-LGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITAT 271

  Fly   272 FPYVIMGVLLVRAVTLPGSIDGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFN 336
            .|||::..||:|.|||||:||||..::...:.::.:..||..|.||..:||.|.||.:|.:||:|
Human   272 MPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYN 336

  Fly   337 KFGHNVHRDAAIVTGLDTMTSLLAGFTIFGILGHLA--HEIGTDDIGSVVKGGAGLAFISYPDAI 399
            ||.:|.:|||.:.|.::::||..:||.:|..||::|  |.:   .||.|.|.|.||.||.||:||
Human   337 KFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSV---PIGDVAKDGPGLIFIIYPEAI 398

  Fly   400 AKFKNLPQIFSVLFFLMLFVLGIGSNIAMTSCSVTAIRDRFPNFGQWQ--CSLLIAVVSFFIGLM 462
            |... |...::|:||:||..|||.|.:......:|.:.|.|....:.:  .:|.|.:.:|.:.|.
Human   399 ATLP-LSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLF 462

  Fly   463 YITPGGQYMLTLVDFFGASMIALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSII 527
            .:|.||.|:.||:|.|.|....|...:.|...:.|.||..:...||:.|.|::..|||||||.::
Human   463 CVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLV 527

  Fly   528 TPLIMTVILIYFYATYQPLTYNNIVYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKI 592
            :|..:..:::....|::|..|...::|:|:.::||:|....:..:||:........|| :...|:
Human   528 SPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPG-SFREKL 591

  Fly   593 RGAFTPKKN 601
            ..|..|:|:
Human   592 AYAIAPEKD 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	201/560 (36%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	203/565 (36%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201	561..590		7/29 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820