Protein Alignment CG15279 and SLC6A1

DIOPT Version :9

• Sequence 1: NP_609726.1
• Gene: CG15279 / 34863
• FlyBaseID: FBgn0028886
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_001335179.1
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Alignment Length: 616
• Identity: 219/616 - (35%)
• Similarity: 331/616 - (53%)
• Gaps: 40/616 - (6%)

  Fly    14 VGDDGRST-ASTVEISTNSPALRDNSDDQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFP 77
            |.|...|| .|...::.:.|........::||.:| :|.||....:|||||:..::|||||||||
Human     8 VADGQISTEVSEAPVANDKPKTLVVKVQKKAADLP-DRDTWKGRFDFLMSCVGYAIGLGNVWRFP 71

  Fly    78 FTALDNGGGAFLIPYLIVLFLIGKPIYYLEMVIGQFSSRGSVKVFDLCPAMKGVGAGQAFQVFML 142
            :....||||||||||.:.|...|.|::.||..:||::|.|.:.|:.|.|..||||...|...|.|
Human    72 YLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWL 136

  Fly   143 STYYAALVAIIGRYFIESFRNPLPWSTCRAEWGIHCINSAPDASNWSQLESNDQRPQNYTMKSQN 207
            :.||..:::....|...||...|||..|...|                  :.|:...||:|  .|
Human   137 NIYYIVIISWAIYYLYNSFTTTLPWKQCDNPW------------------NTDRCFSNYSM--VN 181

  Fly   208 DRVITSSEWYFVKEVLHEKPNIEEGIGLP---NWELVIGLFIAWSCVFFIIRRGVKSSGKASYFL 269
            ...:||:...|.:..:|:   :.:|:..|   .|.|.|.|.|||..|:|.|.:||..:||..||.
Human   182 TTNMTSAVVEFWERNMHQ---MTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFS 243

  Fly   270 ALFPYVIMGVLLVRAVTLPGSIDGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSS 334
            |.:||:::.:|..|.|||||:.:||.::|.|.:.|:.|.:||..|.||.|:|..:..|::|...|
Human   244 ATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGS 308

  Fly   335 FNKFGHNVHRDAAIVTGLDTMTSLLAGFTIFGILGHLAHEIGTDDIGSVVKGGAGLAFISYPDAI 399
            :|.|.:||:||:.||..:::.||:.|||.||.|:|.:|| :....|..|...|.||||::||:|:
Human   309 YNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAH-VTKRSIADVAASGPGLAFLAYPEAV 372

  Fly   400 AKFKNLPQIFSVLFFLMLFVLGIGSNIAMTSCSVTAIRDRFPNFGQWQCSLLIA---VVSFFIGL 461
            .:....| ::::|||.||.:|||.|........:||:.|.:|...:.:..|.||   ::|:.|||
Human   373 TQLPISP-LWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGL 436

  Fly   462 MYITPGGQYMLTLVDFFGAS-MIALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWS 525
            ..||.||.|:..|.|::.|| |..|.|...|..:|.|.||.:|...:|:.|:|.:..::|:||||
Human   437 SNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWS 501

  Fly   526 IITPLIMTVILIYFYATYQPLTYNNIVYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGA 590
            ..||:|:..:.|:......|||..|.|:|.|...:|||:....::.:|.:|....:...| :|..
Human   502 FFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKG-SLKQ 565

  Fly   591 KIRGAFTPKKNW-----GPSDPLLREQYHKE 616
            :|:....|.::.     ||..|.......||
Human   566 RIQVMVQPSEDIVRPENGPEQPQAGSSTSKE 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	204/554 (37%)
SLC6A1	NP_001335179.1	SLC6sbd_GAT1	2..599	CDD:212075	219/616 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		5/20 (25%)
		PDZ-binding	597..599		219/616 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820