DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15279 and slc6a6b

DIOPT Version :9

Sequence 1:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001032750.1	Gene:	slc6a6b / 569098	ZFINID:	ZDB-GENE-030131-3077	Length:	625	Species:	Danio rerio

Alignment Length:	603	Identity:	209/603 - (34%)
Similarity:	334/603 - (55%)	Gaps:	46/603 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SPALRDNSDDQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIV 95
            ||..|  .:|:...|.| :|..|...::||:|.....||||||||||:....||||||||||.|.
Zfish    25 SPGTR--PEDEAEGKHP-QREKWASKLDFLLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIF 86

  Fly    96 LFLIGKPIYYLEMVIGQFSSRGSVKVFD-LCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYFIE 159
            ||..|.|:::||:.:|||:|.|.:..:: |||...|:|......|.:|:.||..::|....|..:
Zfish    87 LFGGGLPVFFLEVALGQFTSEGGITCWEKLCPIFTGIGYASIVIVSLLNIYYIVILAWGLYYLFQ 151

  Fly   160 SFRNPLPWSTCRAEWGI-HCINSA--PDASNWSQLESNDQRPQNYTMKSQNDRVITSSEWYFVKE 221
            .|:..|||::|..:|.. :|:...  .:.:.|:...:.     |:|..      :|.   ::.:.
Zfish   152 CFQPELPWASCNNKWNTENCVEDTLRRNKTLWAAANAT-----NFTSP------VTE---FWERN 202

  Fly   222 VLHEKPNIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRAVT 286
            ||.....||| :|...|:|.:.|...|...||.:.:||||:||..|..|.||:|::.|||||.||
Zfish   203 VLSISDGIEE-VGHVKWDLALCLLAMWVICFFCVWKGVKSTGKVVYVTATFPFVMLIVLLVRGVT 266

  Fly   287 LPGSIDGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIVTG 351
            |||:.:||.:::.|...::.||:||..|.||.|:|.::|.|.:....|:||:.:|.:||..::.|
Zfish   267 LPGAAEGIKFYLYPNVTRLGDPEVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNCYRDCLLLGG 331

  Fly   352 LDTMTSLLAGFTIFGILGHLAHEIGTDDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFSVLFFLM 416
            |::.||.::||.||.:||.:|.|.|. ||..|.:.|.|||||:||.|:.... ||..:::|||:|
Zfish   332 LNSATSFVSGFAIFSVLGFMAQEQGV-DIADVAESGPGLAFIAYPKAVTMMP-LPTFWAILFFIM 394

  Fly   417 LFVLGIGSNIAMTSCSVTAIRDRFPNFGQ--WQCSLLIAV---VSFFIGLMYITPGGQYMLTLVD 476
            |.:||:.|........:|::.|.:|:|.:  ::..:.||:   ||:.:||..:|.||.|:..|.|
Zfish   395 LLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAIVCFVSYLLGLTMVTEGGMYVFQLFD 459

  Fly   477 FFGASMIALV-LGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIYFY 540
            ::.||.:.|: :...|...:.|:||.|.....||.|:|.:...:.:..|:::||.:.....|:..
Zfish   460 YYAASGVCLLWVAFFECIAVAWVYGADNFYDAIEEMIGYRPNPWMKWSWTVVTPFLCVGCFIFSL 524

  Fly   541 ATYQPLTYNNIV-YPNWSYSIGWLITAFGILQLPIWMIVAIVRDPG------QTLGAKIRGA--- 595
            ..|.||.||.|. ||:||..:||.:....::.:|:.:::.|::..|      :.:.|.:||.
Zfish   525 VKYAPLRYNKIYEYPDWSIGVGWTLALASMICIPMVVVIKIIQSDGPLIERIKAVAAPVRGGASS 589

  Fly   596 ----FTPKKN--WGPSDP 607
                :.||.|  ..|.||
Zfish   590 CPQEYQPKSNELAQPLDP 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	197/571 (35%)
slc6a6b	NP_001032750.1	SLC6sbd_TauT	41..582	CDD:271398	194/557 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920