DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15279 and slc6a8

DIOPT Version :9

Sequence 1:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001314797.1	Gene:	slc6a8 / 567544	ZFINID:	ZDB-GENE-071024-2	Length:	652	Species:	Danio rerio

Alignment Length:	608	Identity:	226/608 - (37%)
Similarity:	331/608 - (54%)	Gaps:	76/608 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 ERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIVLFLIGKPIYYLEMVIGQF 113
            ||.||.:.::|:|||:..:||||||||||:....||||.|||||::.:||.|.||::||:.:|||
Zfish    63 ERETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLFIFLGGIPIFFLEIALGQF 127

  Fly   114 SSRGSVKVFDLCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYFIESFRNPLPWSTCRAEWGIH- 177
            ...||:.|:::.|..||:|......||..:|||..::|....|||:||...||||||...|...
Zfish   128 MKAGSINVWNIAPLFKGLGYASMVIVFFCNTYYIMVLAWGFYYFIKSFNATLPWSTCDNPWNTEN 192

  Fly   178 ---------CINSAPDASNWSQLE----SNDQRPQNYTMKSQNDRVITSSEWYFVKEVLHEKPNI 229
                     |.|.....|.:..|.    :|.:.|           :|.    ::..:||    ||
Zfish   193 CIEIFRQGDCKNGTIGNSTFGNLTCEELANGRSP-----------IIE----FWENKVL----NI 238

  Fly   230 EEGI---GLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRAVTLPGSI 291
            .:|:   |..||||::.|...|..|:|.:.:||||:||..||.|.||||::.:||||.|||||:.
Zfish   239 SDGLDEPGAVNWELMLCLLAVWVMVYFCVWKGVKSTGKIVYFTATFPYVVLIILLVRGVTLPGAY 303

  Fly   292 DGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIVTGLDTMT 356
            |||.|::||.|.|:.:.:||..|.||.|:|.::..|.:....|:|:|.::.::||.::..:::.|
Zfish   304 DGILYYVKPDWSKLGEAQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNDCYKDAFVLALINSGT 368

  Fly   357 SLLAGFTIFGILGHLAHEIGTDDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFSVLFFLMLFVLG 421
            |..|||.:|.|||.:|.|.|. ||..|.:.|.|||||:||.|::.....| :::.|||:||.:||
Zfish   369 SFFAGFVVFSILGFMASEQGV-DISKVAESGPGLAFIAYPKAVSMMPVAP-VWAALFFIMLLLLG 431

  Fly   422 IGSNIAMTSCSVTAIRDRFPN--FGQWQCSLLIAV---VSFFIGLMYITPGGQYMLTLVDFFGAS 481
            :.|........||.|.|.||.  :.::|..:.:|:   :.|.|.|..:|.||.|:..|.|::.||
Zfish   432 LDSQFVGVEGFVTGILDLFPGKYYMRYQREIAVAICCLLCFIIDLSMVTQGGMYVFQLFDYYSAS 496

  Fly   482 -MIALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIYFYATYQP 545
             |..|.....|...:.|:||.||...||..|:|.:...:.:.|||||||.:...|.::....|:|
Zfish   497 GMTLLWQAFWECVVVAWVYGADRFMDDIARMIGYRPFPWMKWCWSIITPCVCMGIFLFHLLNYKP 561

  Fly   546 LTYNNI-VYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPKKNWGPSDPLL 609
            |||||: |||.|...|||.:....:|.:|:.::..:       .|||  |.|  |:.|
Zfish   562 LTYNNVYVYPWWGEVIGWCLALSSMLCIPVSLVYKL-------SGAK--GTF--KERW------- 608

  Fly   610 REQYHKEIENELTPKRGQGIWAA 632
                    ||...|     :|.|
Zfish   609 --------ENLTKP-----VWGA 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	218/571 (38%)
slc6a8	NP_001314797.1	SLC6sbd_CT1	64..652	CDD:271397	225/607 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820