DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15279 and slc6a2

DIOPT Version :9

Sequence 1:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_009301625.1	Gene:	slc6a2 / 565776	ZFINID:	ZDB-GENE-110408-4	Length:	625	Species:	Danio rerio

Alignment Length:	573	Identity:	206/573 - (35%)
Similarity:	320/573 - (55%)	Gaps:	47/573 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TASTVEISTNSPALRDNSDDQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGG 85
            |.|:|..|.:|.|....|.::      .||.||||.::||:|.|..:|.|.||||||:....|||
Zfish    41 TNSSVVASPSSRACTSASGEE------IERETWGKKMDFLLSVIGFAVDLANVWRFPYLCYKNGG 99

  Fly    86 GAFLIPYLIVLFLIGKPIYYLEMVIGQFSSRGSVKVFDLCPAMKGVGAGQAFQVFMLSTYYAALV 150
            |||||||::.||:.|.|::|:|:.:||::..|:..::.:||..||||.........:..||..::
Zfish   100 GAFLIPYVLFLFIAGMPLFYMELALGQYNREGAATLWKICPVFKGVGYTVIVIALYVGFYYNVII 164

  Fly   151 AIIGRYFIESFRNPLPWSTCRAEWGIHCINSAPDASNWSQLESNDQRPQNYTM--------KSQN 207
            |....|...|..:.|||        :||.|.      |:.....:.:..|.|:        |.:|
Zfish   165 AWSLYYLYASLTSELPW--------LHCNNP------WNSPNCTEPKDINGTVLGNGTSYAKYKN 215

  Fly   208 DRVITSSEWYFVKEVL--HEKPNIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLA 270
                |.:..::.:.||  ||...|.: :|||.|||.|.|.:....::|.:.:|||||||..|..|
Zfish   216 ----TPAAEFYERGVLHSHESKGIGD-LGLPRWELTICLVVVAFILYFSLWKGVKSSGKVVYITA 275

  Fly   271 LFPYVIMGVLLVRAVTLPGSIDGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSF 335
            ..||:::.|||:|.:||||:::||..::.....|:.:|:||..|.||.|:||...||.:|.:||:
Zfish   276 TMPYIVLLVLLIRGITLPGAMNGIRAYLHIDLKKLNNPQVWIDAATQIFFSLGAGFGVLIAFSSY 340

  Fly   336 NKFGHNVHRDAAIVTGLDTMTSLLAGFTIFGILGHLA--HEIGTDDIGSVVKGGAGLAFISYPDA 398
            |||.:|.:|||.:.:.::.:||..:||.||.:||::|  |::...|:.:   .||||.|:.||:|
Zfish   341 NKFNNNCYRDAILTSTINCVTSFFSGFAIFSVLGYMAEQHKVNIKDVAT---EGAGLVFVIYPEA 402

  Fly   399 IAKFKNLP--QIFSVLFFLMLFVLGIGSNIAMTSCSVTAIRDRFPNFGQWQCSLLIAVV--SFFI 459
            |:   .||  ..|:::||:||..|||.|::......:|.:.|.|....:.:.....|.|  :|.:
Zfish   403 IS---TLPGATFFAIVFFIMLLTLGIDSSMGGMEAVLTGLSDDFKILKRNRKLFTFATVVGTFLM 464

  Fly   460 GLMYITPGGQYMLTLVDFFGASMIALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCW 524
            .|:.:|.||.|:|||:|.:.|....|...:.|...:.|.||.||..:|||.|:|.|.|:||||||
Zfish   465 ALLCVTNGGIYVLTLLDKYAAGTSILFGVLFEAIGVSWFYGVDRFSEDIERMMGFKPGIYWRLCW 529

  Fly   525 SIITPLIMTVILIYFYATYQPLTYNNIVYPNWSYSIGWLITAFGILQLPIWMI 577
            ..::|..:.:::|....|...|||:..|:|.|:..:||.|....:|.:|.:.|
Zfish   530 KFVSPAFLLLVVIASIVTSGRLTYDEYVFPYWADMLGWSIALSSMLFVPFYAI 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	198/544 (36%)
slc6a2	XP_009301625.1	SLC5-6-like_sbd	64..623	CDD:294310	198/544 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920