DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15279 and slc6a22.2

DIOPT Version :9

Sequence 1:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_005166102.1	Gene:	slc6a22.2 / 561024	ZFINID:	ZDB-GENE-030616-628	Length:	608	Species:	Danio rerio

Alignment Length:	595	Identity:	216/595 - (36%)
Similarity:	329/595 - (55%)	Gaps:	32/595 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 TNSPALRDNSDDQEAAKV---PEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLI 90
            ::.||::.|..:....|.   |..|..|...:|||::.....:|||||||||:....||||||.:
Zfish     4 SSRPAVKLNLLNGALVKARPKPPAREQWANKLEFLLAVAGHIIGLGNVWRFPYLCYKNGGGAFFV 68

  Fly    91 PYLIVLFLIGKPIYYLEMVIGQFSSRGSVKVF-DLCPAMKGVGAGQAFQVFMLSTYYAALVAIIG 154
            ||::.||..|.|:::||..:|||:|:|.:..: .:||..:|:|.|....|.....||..::|...
Zfish    69 PYVLFLFTCGIPLFFLETSLGQFTSQGGITCWRKICPLFEGLGFGSQVVVLYTGVYYIIILAWAF 133

  Fly   155 RYFIESFRNPLPWSTCRAEWGIHCINSAPDASNWSQLESNDQRPQNYTMKSQNDRVITSSEWYFV 219
            .|...||.:.|||::|...|      :.|....:|:        .|.|..|.|.......| ::.
Zfish   134 LYLFSSFTSELPWASCNNYW------NTPSCMEFSE--------SNITEYSPNKTTSPVIE-FWE 183

  Fly   220 KEVLHEKPNIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRA 284
            :.:|.....||: ||...|:|.:.|.:||...:|.:.:||||:||..||.|.|||:::.|||||.
Zfish   184 RRILGLSGGIEQ-IGNVRWDLALCLLLAWIICYFCVWKGVKSTGKVVYFTATFPYLMLIVLLVRG 247

  Fly   285 VTLPGSIDGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIV 349
            :||||:|:||.:::.|...::.||:||..|.:|.|||..||.|.:....|:||:.:|.:||...:
Zfish   248 LTLPGAINGITFYLYPDPSRLKDPQVWMDAGSQIFYSYGVCTGVLTALGSYNKYDNNCYRDCVYL 312

  Fly   350 TGLDTMTSLLAGFTIFGILGHLAHEIGTDDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFSVLFF 414
            ..|:::||.:|||.||.:||.:|.|.|. ||..|.:.|.|||||:||.|:| ...|||::::.||
Zfish   313 CLLNSLTSFVAGFAIFSVLGFMADEQGV-DISLVAESGPGLAFIAYPRAVA-LMPLPQLWAIFFF 375

  Fly   415 LMLFVLGIGSNIAMTSCSVTAIRDRFPNF---GQWQCSLLIAV--VSFFIGLMYITPGGQYMLTL 474
            :|:..||:.|........||:|.|.:|:|   |..:..||:.:  .|||:||:.:|.||.|:..|
Zfish   376 IMIIFLGLDSEFVYQEALVTSISDMYPSFFQVGHRRKFLLLFICSASFFVGLLMVTEGGLYVFQL 440

  Fly   475 VDFFGAS-MIALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIY 538
            .|::..| |..|...|.:...:||:||.||....:|.|:|.:...:.:.||..:||.|.|...|:
Zfish   441 FDYYACSGMTLLTFAILQSICVGWVYGADRHYDCVEDMIGYRPWPFMKCCWKYLTPAICTGTFIF 505

  Fly   539 FYATYQPLTYNN-IVYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPKKNW 602
            ....|.||.:|| ..||.|.|:||...|....|.:|:|||..:...|| ::..::|...||.::.
Zfish   506 SLVQYTPLKFNNEYEYPWWGYAIGGFFTLSSTLLVPLWMIYLVGTTPG-SMRQRVRALCTPAEDL 569

  Fly   603 GPSDPLLREQ 612
              .||...:|
Zfish   570 --PDPKCPKQ 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	206/555 (37%)
slc6a22.2	XP_005166102.1	SLC6sbd-TauT-like	28..565	CDD:271387	206/555 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820