DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15279 and SLC6A15

DIOPT Version :9

Sequence 1:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_877499.1	Gene:	SLC6A15 / 55117	HGNCID:	13621	Length:	730	Species:	Homo sapiens

Alignment Length:	715	Identity:	208/715 - (29%)
Similarity:	343/715 - (47%)	Gaps:	133/715 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DGRSTASTVEISTNSPALRD---------------NSDDQEAAKVPEERATWGKGVEFLMSCIAM 66
            |...|.|..::.:|..|..|               ::|.:|.::|.:||..|...::::::.:..
Human    13 DDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDERPAWNSKLQYILAQVGF 77

  Fly    67 SVGLGNVWRFPFTALDNGGGAFLIPYLIVLFLIGKPIYYLEMVIGQFSSRGSVKVFD-LCPAMKG 130
            |||||||||||:....|||||:|:||||:|.:||.|:::||:.:||...|||:.|:: :.|.:.|
Human    78 SVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGG 142

  Fly   131 VGAGQAFQVFMLSTYYAALVAIIGRYFIESFRNPLPWSTCRAEWGIHCINSAPDASNWSQLESND 195
            :|.......:.::.||..::.....||.:||:.||||..|            |...|.|
Human   143 IGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQC------------PLVKNAS------ 189

  Fly   196 QRPQNYTMKSQNDRVITSSEWYFVKEVLHEKPNIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVK 260
                 :|.........:::.:|:.:|.|:...:|.|..|| ||::.|.|..||..|...:.:|::
Human   190 -----HTFVEPECEQSSATTYYWYREALNISSSISESGGL-NWKMTICLLAAWVMVCLAMIKGIQ 248

  Fly   261 SSGKASYFLALFPYVIMGVLLVRAVTLPGSIDGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVC 325
            ||||..||.:|||||::...|:||..|.||||||.:...|:...:|:||||..|.||.|::|.:.
Human   249 SSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLG 313

  Fly   326 FGNIIMYSSFNKFGHNVHRDAAIVTGLDTMTSLLAGFTIFGILG--------------------- 369
            ||.:|.:||:||..:|.|.||.:|:.::..||:||...:|.:||
Human   314 FGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKF 378

  Fly   370 -------------------------HLAHEI------------------GTDDIGSVVKGGAGLA 391
                                     ||.::|                  ..:::...|: |.|||
Human   379 LKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQ-GTGLA 442

  Fly   392 FISYPDAIAKFKNLPQIFSVLFFLMLFVLGIGSNIAMTSCSVTAIRDRFPNFGQWQCSLLIAVVS 456
            ||::.:|:..|...| .:||:|||||..||:||........||.|.|.| ...:...:::..:::
Human   443 FIAFTEAMTHFPASP-FWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF-KVRKEILTVICCLLA 505

  Fly   457 FFIGLMYITPGGQYMLTLVDFFGASMIALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWR 521
            |.|||:::...|.|.:|:.|.:.|::..|::.|.|...:.::||.|:..:|::.|||.....|:.
Human   506 FCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYY 570

  Fly   522 LCWSIITPLIMTVILIYFYAT--YQPLTYNN----------IVYPNWSYSIGWLITAFGILQLPI 574
            ..|..|:||::..:||.....  ..|..||.          :.||.|...:...:..|.||.:|:
Human   571 YMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPV 635

  Fly   575 WMIVA---IVRDPGQTLGAKIRGAFTPKKNWGPSDPLLRE-----QYHKEIENEL-TPKRGQGIW 630
            ..||.   ::.|....|     .:.|.|:.....:|:..|     ..|.:|.:|: :|..|:.|:
Human   636 VFIVRRFNLIDDSSGNL-----ASVTYKRGRVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIY 695

Fly 631 630
Human 696 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	188/627 (30%)
SLC6A15	NP_877499.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..60		3/18 (17%)
SLC6A15	NP_877499.1	SLC6sbd_SBAT1	61..640	CDD:212091	185/605 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820