DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15279 and SLC6A17

DIOPT Version :9

Sequence 1:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001010898.1	Gene:	SLC6A17 / 388662	HGNCID:	31399	Length:	727	Species:	Homo sapiens

Alignment Length:	690	Identity:	206/690 - (29%)
Similarity:	330/690 - (47%)	Gaps:	141/690 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TQRNHQN---LAFVGD--------DGRSTASTV--EISTNSPALRDNSDDQEAAKVPEERATWGK 55
            |||.|.:   ...|.|        |.:.:...|  |......|:.:..|       .|:|..|..
Human     8 TQREHSSEHVTESVADLLALEEPVDYKQSVLNVAGEAGGKQKAVEEELD-------AEDRPAWNS 65

  Fly    56 GVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIVLFLIGKPIYYLEMVIGQFSSRGSVK 120
            .::::::.|..||||||:||||:....|||||:|:|||::|.:||.|:::||:.:||...|||:.
Human    66 KLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIG 130

  Fly   121 VFD-LCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYFIESFRNPLPWSTCRAEWGIHCINSAPD 184
            |:. :||.:.|:|.........:..||..::.....||.:||:.|||||.|            |.
Human   131 VWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSEC------------PV 183

  Fly   185 ASNWS--QLESNDQRPQNYTMKSQNDRVITSSEWYFVKEVLHEKPNIEEGIGLPNWELVIGLFIA 247
            ..|.|  .:|:..::..           .|:..||  :|.|....:|.|..|| ||::.:.|.:|
Human   184 VRNGSVAVVEAECEKSS-----------ATTYFWY--REALDISDSISESGGL-NWKMTLCLLVA 234

  Fly   248 WSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRAVTLPGSIDGIYYFIKPQWGKILDPKVWY 312
            ||.|...:.:|::||||..||.:|||||::...|||.:.|.|::|||.:...|:..|:|||:||.
Human   235 WSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWR 299

  Fly   313 AAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIVTGLDTMTSLLAGFTIFGILG-------- 369
            .|.||.|::|.:.||.:|.:||:||..:|.|.|||:|:.::..||:||...:|.:||
Human   300 EAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNE 364

  Fly   370 -------------------------------HLAHE-------------------IG------TD 378
                                           ||..:                   :|      .|
Human   365 KCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLED 429

  Fly   379 DIGSVVKGGAGLAFISYPDAIAKFKNLPQIFSVLFFLMLFVLGIGSNIAMTSCSVTAIRDRFPNF 443
            ::...|: |.|||||::.:|:..|...| .:||:|||||..||:||.|...:...|.|.|.| ..
Human   430 ELDKSVQ-GTGLAFIAFTEAMTHFPASP-FWSVMFFLMLINLGLGSMIGTMAGITTPIIDTF-KV 491

  Fly   444 GQWQCSLLIAVVSFFIGLMYITPGGQYMLTLVDFFGASMIALVLGIAELYTIGWIYGTDRLCKDI 508
            .:...::...|.:|.:||:::...|.|.:|:.|.:.|::...::.|.|...:.|||||.:..:::
Human   492 PKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYGTKKFMQEL 556

  Fly   509 EFMLGRKVGLYWRLCWSIITPLIMTVI----LIYFYATYQPLTYN----------NIVYPNWSYS 559
            ..|||.:...::...|..::||.|.|:    :|....|  |..|:          .:.:|||:.:
Human   557 TEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVT--PPGYSAWIKEEAAERYLYFPNWAMA 619

  Fly   560 IGWLITAFGILQLPIWMIVAIVR------DPGQTLGAKIR 593
            :  |||...:..||| .:|.::|      |...||....:
Human   620 L--LITLIVVATLPI-PVVFVLRHFHLLSDGSNTLSVSYK 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	194/631 (31%)
SLC6A17	NP_001010898.1	SLC6sbd_NTT4	60..648	CDD:271403	192/621 (31%)
SLC6A17	NP_001010898.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820