DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15279 and Slc6a3

DIOPT Version :9

Sequence 1:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_036826.1	Gene:	Slc6a3 / 24898	RGDID:	3715	Length:	619	Species:	Rattus norvegicus

Alignment Length:	583	Identity:	204/583 - (34%)
Similarity:	322/583 - (55%)	Gaps:	36/583 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 TNSPALRDNSDDQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYL 93
            |||..:.......||    :||.||.|.::||:|.|..:|.|.||||||:....|||||||:|||
  Rat    43 TNSTLINPPQTPVEA----QERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYL 103

  Fly    94 IVLFLIGKPIYYLEMVIGQFSSRGSVKVFDLCPAMKGVGAGQAFQVFMLSTY----YAALVAIIG 154
            :.:.:.|.|::|:|:.:|||:..|:..|:.:||.:||||    |.|.::|.|    |..::|...
  Rat   104 LFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVG----FTVILISFYVGFFYNVIIAWAL 164

  Fly   155 RYFIESFRNPLPWSTCRAEWGIHCINSAPDASNWSQLESNDQRPQNYTMKSQNDRVITSSEWYFV 219
            .||..||...|||..|...|      ::|:.|:.....|:|....|.|..:      |.:..||.
  Rat   165 HYFFSSFTMDLPWIHCNNTW------NSPNCSDAHASNSSDGLGLNDTFGT------TPAAEYFE 217

  Fly   220 KEV--LHEKPNIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLV 282
            :.|  ||:...|:: :|.|.|:|...|.:....::|.:.:|||:|||..:..|..|||::..||:
  Rat   218 RGVLHLHQSRGIDD-LGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLL 281

  Fly   283 RAVTLPGSIDGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAA 347
            |.|||||::|||..::...:.::.:..||..|.||..:||.|.||.:|.:||:|||.:|.:|||.
  Rat   282 RGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAI 346

  Fly   348 IVTGLDTMTSLLAGFTIFGILGHLA--HEIGTDDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFS 410
            |.|.::::||..:||.:|..||::|  |.:...|:.:   .|.||.||.||:|||... |...::
  Rat   347 ITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVAT---DGPGLIFIIYPEAIATLP-LSSAWA 407

  Fly   411 VLFFLMLFVLGIGSNIAMTSCSVTAIRDRFPNFGQWQ--CSLLIAVVSFFIGLMYITPGGQYMLT 473
            .:|||||..|||.|.:......:|.:.|.|....:.:  .:|.|.:.:|.:.|..:|.||.|:.|
  Rat   408 AVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFT 472

  Fly   474 LVDFFGASMIALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIY 538
            |:|.|.|....|...:.|...:.|.||..:...||:.|.|::..|||||||.:::|..:..:::.
  Rat   473 LLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVV 537

  Fly   539 FYATYQPLTYNNIVYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPKKN 601
            ...|::|..|...::|:|:.::||:|....:..:||:........|| :...|:..|.||:|:
  Rat   538 SIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPG-SFREKLAYAITPEKD 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	195/557 (35%)
Slc6a3	NP_036826.1	SLC6sbd_DAT1	60..613	CDD:212083	198/562 (35%)
Slc6a3	NP_036826.1	Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		7/29 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820