Protein Alignment CG15279 and Slc6a3

DIOPT Version :10

• Sequence 1: NP_609726.1
• Gene: CG15279 / 34863
• FlyBaseID: FBgn0028886
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_036826.1
• Gene: Slc6a3 / 24898
• RGDID: 3715
• Length: 619
• Species: Rattus norvegicus
• Alignment Length: 583
• Identity: 204/583 - (34%)
• Similarity: 322/583 - (55%)
• Gaps: 36/583 - (6%)

  Fly    29 TNSPALRDNSDDQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYL 93
            |||..:.......||    :||.||.|.::||:|.|..:|.|.||||||:....|||||||:|||
  Rat    43 TNSTLINPPQTPVEA----QERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYL 103

  Fly    94 IVLFLIGKPIYYLEMVIGQFSSRGSVKVFDLCPAMKGVGAGQAFQVFMLSTY----YAALVAIIG 154
            :.:.:.|.|::|:|:.:|||:..|:..|:.:||.:||||    |.|.::|.|    |..::|...
  Rat   104 LFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVG----FTVILISFYVGFFYNVIIAWAL 164

  Fly   155 RYFIESFRNPLPWSTCRAEWGIHCINSAPDASNWSQLESNDQRPQNYTMKSQNDRVITSSEWYFV 219
            .||..||...|||..|...|      ::|:.|:.....|:|....|.|..:      |.:..||.
  Rat   165 HYFFSSFTMDLPWIHCNNTW------NSPNCSDAHASNSSDGLGLNDTFGT------TPAAEYFE 217

  Fly   220 KEV--LHEKPNIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLV 282
            :.|  ||:...|:: :|.|.|:|...|.:....::|.:.:|||:|||..:..|..|||::..||:
  Rat   218 RGVLHLHQSRGIDD-LGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLL 281

  Fly   283 RAVTLPGSIDGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAA 347
            |.|||||::|||..::...:.::.:..||..|.||..:||.|.||.:|.:||:|||.:|.:|||.
  Rat   282 RGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAI 346

  Fly   348 IVTGLDTMTSLLAGFTIFGILGHLA--HEIGTDDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFS 410
            |.|.::::||..:||.:|..||::|  |.:...|:.:   .|.||.||.||:|||... |...::
  Rat   347 ITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVAT---DGPGLIFIIYPEAIATLP-LSSAWA 407

  Fly   411 VLFFLMLFVLGIGSNIAMTSCSVTAIRDRFPNFGQWQ--CSLLIAVVSFFIGLMYITPGGQYMLT 473
            .:|||||..|||.|.:......:|.:.|.|....:.:  .:|.|.:.:|.:.|..:|.||.|:.|
  Rat   408 AVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFT 472

  Fly   474 LVDFFGASMIALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIY 538
            |:|.|.|....|...:.|...:.|.||..:...||:.|.|::..|||||||.:::|..:..:::.
  Rat   473 LLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVV 537

  Fly   539 FYATYQPLTYNNIVYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPKKN 601
            ...|::|..|...::|:|:.::||:|....:..:||:........|| :...|:..|.||:|:
  Rat   538 SIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPG-SFREKLAYAITPEKD 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:444915	195/557 (35%)
Slc6a3	NP_036826.1	SLC6sbd_DAT1	60..613	CDD:212083	198/562 (35%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		7/29 (24%)