DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15279 and Slc6a6

DIOPT Version :9

Sequence 1:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_030111163.1	Gene:	Slc6a6 / 21366	MGIID:	98488	Length:	631	Species:	Mus musculus

Alignment Length:	588	Identity:	209/588 - (35%)
Similarity:	331/588 - (56%)	Gaps:	40/588 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SPALRDNSDDQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIV 95
            ||..|   .:.||...|.:|..|...::|::|.....||||||||||:....||||||||||.|.
Mouse    35 SPGTR---PEDEADGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIF 96

  Fly    96 LFLIGKPIYYLEMVIGQFSSRGSVKVFD-LCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYFIE 159
            ||..|.|:::||::|||::|.|.:..:: :||...|:|......|.:|:.||..::|....|...
Mouse    97 LFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFH 161

  Fly   160 SFRNPLPWSTCRAEWGI-HCINSA--PDASNWSQLESNDQRPQNYTMKSQNDRVITSSEWYFVKE 221
            ||:..|||:.|...|.. .|:...  .:.|:|..|.:     .|:|     ..||.    ::.:.
Mouse   162 SFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLST-----ANFT-----SPVIE----FWERN 212

  Fly   222 VLHEKPNIEEGIGLP---NWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVR 283
            ||    ::..||..|   .|:|.:.|.:.|...||.|.:||:|:||..||.|.||:.::.|||||
Mouse   213 VL----SLSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVR 273

  Fly   284 AVTLPGSIDGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAI 348
            .:||||:.:||.:::.|...::.||:||..|.||.|:|.::|.|.:....|:||:.:|.:||..:
Mouse   274 GLTLPGAGEGIKFYLYPDISRLGDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCML 338

  Fly   349 VTGLDTMTSLLAGFTIFGILGHLAHEIGTDDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFSVLF 413
            :..|::.||.::||.||.|||.:|.|.|. ||..|.:.|.|||||:||.|:.... ||..:|:||
Mouse   339 LGCLNSGTSFVSGFAIFSILGFMAQEQGV-DIADVAESGPGLAFIAYPKAVTMMP-LPTFWSILF 401

  Fly   414 FLMLFVLGIGSNIAMTSCSVTAIRDRFPNFGQ--WQCSLLIAV---VSFFIGLMYITPGGQYMLT 473
            |:||.:||:.|........:|::.|.:|:|.:  ::..:.||:   :|:.:||..:|.||.|:..
Mouse   402 FIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAILCSISYLLGLTMVTEGGMYVFQ 466

  Fly   474 LVDFFGASMIALV-LGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILI 537
            |.|::.||.:.|: :...|.:.|.||||.|.|...||.|:|.:.|.:.:..|::|||.:.....:
Mouse   467 LFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPALCVGCFV 531

  Fly   538 YFYATYQPLTYNNIV-YPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPKK- 600
            :....|.|||||.:. ||:|:..:||.:....:|.:|:.:::.:.|..| .|..:|:...||::
Mouse   532 FSLVKYVPLTYNKVYRYPDWAIGLGWGLALSSMLCIPLVIVILLCRTEG-PLRVRIKYLITPREP 595

  Fly   601 -NW 602
             .|
Mouse   596 NRW 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	200/561 (36%)
Slc6a6	XP_030111163.1	SLC5-6-like_sbd	51..592	CDD:382020	200/561 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820