Protein Alignment CG15279 and Slc6a4

DIOPT Version :9

• Sequence 1: NP_609726.1
• Gene: CG15279 / 34863
• FlyBaseID: FBgn0028886
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_034614.2
• Gene: Slc6a4 / 15567
• MGIID: 96285
• Length: 630
• Species: Mus musculus
• Alignment Length: 641
• Identity: 214/641 - (33%)
• Similarity: 352/641 - (54%)
• Gaps: 68/641 - (10%)

  Fly     1 MDTTQRNHQNLAFVGDD------------GRST----ASTVEISTNSPALRDNSDDQEA------ 43
            |:||..|.|.:.....|            |..|    |...:||....|:...|...||
Mouse     1 METTPLNSQKVLSECKDKEDCQENGVLQKGVPTPADKAGPGQISNGYSAVPSTSAGDEAPHSTPA 65

  Fly    44 ------AKVPE-ERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIVLFLIGK 101
                  |::.: ||.||||.::||:|.|..:|.|||:||||:....|||||||:||.|:....|.
Mouse    66 ATTTLVAEIHQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGI 130

  Fly   102 PIYYLEMVIGQFSSRGSVKVF-DLCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYFIESFRNPL 165
            |::|:|:.:||:...|.:.:: .:||..||:|.......|.:::||..::|....|.|.||.:.|
Mouse   131 PLFYMELALGQYHRNGCISIWKKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSFTDQL 195

  Fly   166 PWSTCRAEWGI-HCIN-SAPDASNWSQLESNDQRPQNYTMKSQNDRVITSSEWYFVKEVL--HEK 226
            ||::|:..|.. :|.| .|.|...|             |:.|     .:.:|.::::.||  |:.
Mouse   196 PWTSCKNSWNTGNCTNYFAQDNITW-------------TLHS-----TSPAEEFYLRHVLQIHQS 242

  Fly   227 PNIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRAVTLPGSI 291
            ..::: :|..:|:|.:.:.:.::.::|.|.:|||:|||..:..|.|||:::.|||||..||||:.
Mouse   243 KGLQD-LGTISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAW 306

  Fly   292 DGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIVTGLDTMT 356
            .|:.:::||.|.|:|:..||..|..|.|:||...||.::.::|:|||.:|.::||.:.:.::.||
Mouse   307 RGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMT 371

  Fly   357 SLLAGFTIFGILGHLAHEIGTDDIGSVVK-GGAGLAFISYPDAIAKFKNLP--QIFSVLFFLMLF 418
            |.::||.||.:||::| |:..:|:..|.| .|..|.||:|.:|||   |:|  ..|:::|||||.
Mouse   372 SFVSGFVIFTVLGYMA-EMRNEDVSEVAKDAGPSLLFITYAEAIA---NMPASTFFAIIFFLMLI 432

  Fly   419 VLGIGSNIAMTSCSVTAIRDRFPNFGQW----QCSLLIAVVSFFIG-LMYITPGGQYMLTLVDFF 478
            .||:.|..|.....:||:.|.||:.  |    :..:||.|::..:| |:.:|.||.|::||::.:
Mouse   433 TLGLDSTFAGLEGVITAVLDEFPHI--WAKRREWFVLIVVITCILGSLLTLTSGGAYVVTLLEEY 495

  Fly   479 GASMIALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIYFYATY 543
            ......|.:.:.|...:.|.||..:.|.|::.|||...|.:||:||..|:||.:..|:..|..:.
Mouse   496 ATGPAVLTVALIEAVVVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSP 560

  Fly   544 QPLTYNNIVYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPK 599
            ..|......||:||..:|:.|....::.:||::|..::..|| ||..:|..:.||:
Mouse   561 PQLRLFQYNYPHWSIILGYCIGTSSVICIPIYIIYRLISTPG-TLKERIIKSITPE 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	195/560 (35%)
Slc6a4	NP_034614.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		15/61 (25%)
		5HT_transport_N	24..64	CDD:281488	9/39 (23%)
		SLC6sbd_SERT	79..615	CDD:271399	196/561 (35%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624		214/641 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820