DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15279 and Slc6a12

DIOPT Version :9

Sequence 1:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001368835.1	Gene:	Slc6a12 / 14411	MGIID:	95628	Length:	628	Species:	Mus musculus

Alignment Length:	584	Identity:	213/584 - (36%)
Similarity:	327/584 - (55%)	Gaps:	44/584 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIVLFLIGKPIY 104
            ||:.....::|..|...:||::|.....:|||||||||:....||||||.|||.|..|..|.|::
Mouse    40 DQKGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVF 104

  Fly   105 YLEMVIGQFSSRGSVKVF-DLCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYFIESFRNPLPWS 168
            :||:.:||:||:|||..: .:||.::|:|.........|:.||..::|....|...||...|||:
Mouse   105 FLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWT 169

  Fly   169 TCRAEWGI-HCINSAPDASNWSQLESNDQRPQNYT---MKSQNDRV--ITSSEWYFVKEVLHEKP 227
            ||...|.. ||:    |..|.|....... .:|:|   |:....||  |||.        :|:
Mouse   170 TCTNSWNTEHCV----DFLNHSSARGVSS-SENFTSPVMEFWERRVLGITSG--------IHD-- 219

  Fly   228 NIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRAVTLPGSID 292
                 :|...|||.:.|.:||...:|.|.:||||:||..||.|.|||:::.:||:|.|||||:..
Mouse   220 -----LGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQ 279

  Fly   293 GIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIVTGLDTMTS 357
            ||.:::||...::.||:||..|.||.|:|.::|.|.:....|:||:.:|.:||:..:..|::.||
Mouse   280 GIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATS 344

  Fly   358 LLAGFTIFGILGHLAHEIGTDDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFSVLFFLMLFVLGI 422
            .:|||.:|.|||.::.|.|. .|..|.:.|.|||||::|.|:.... |.|::|.|||:||..||:
Mouse   345 FVAGFVVFSILGFMSQEQGI-PISEVAESGPGLAFIAFPKAVTMMP-LSQLWSCLFFIMLLFLGL 407

  Fly   423 GSNIAMTSCSVTAIRDRFP----NFGQWQCSLL-IAVVSFFIGLMYITPGGQYMLTLVDFFGASM 482
            .|......|.|||..|.||    ..|:.:..:| |:|:.:.:||:.:|.||.|:..|.|::.:|.
Mouse   408 DSQFVCMECLVTASMDMFPQQLRKSGRRELLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSG 472

  Fly   483 IALV-LGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIYFYATYQPL 546
            |.|: |.:.|:..|||:||.||...::|.|:|.:.....::.|..:||.:......:..:.|.||
Mouse   473 ICLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPL 537

  Fly   547 TYNNI-VYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPKKNWGPSDPLL 609
            .|||: :||:|.||||||:....:..:|:::|:..::..| :...::|...||       ||.|
Mouse   538 KYNNVYMYPSWGYSIGWLLAFSSMACVPLFIIITFLKTQG-SFKKRLRRLITP-------DPSL 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	206/561 (37%)
Slc6a12	NP_001368835.1	SLC5-6-like_sbd	49..589	CDD:382020	206/562 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820