DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG15279 and Slc6a3

DIOPT Version :9

Sequence 1:NP_609726.1 Gene:CG15279 / 34863 FlyBaseID:FBgn0028886 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_034150.1 Gene:Slc6a3 / 13162 MGIID:94862 Length:619 Species:Mus musculus


Alignment Length:583 Identity:203/583 - (34%)
Similarity:321/583 - (55%) Gaps:36/583 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 TNSPALRDNSDDQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYL 93
            |||..:.......|.    :||.||.|.::||:|.|..:|.|.||||||:....|||||||:|||
Mouse    43 TNSTLINPPQTPVEV----QERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYL 103

  Fly    94 IVLFLIGKPIYYLEMVIGQFSSRGSVKVFDLCPAMKGVGAGQAFQVFMLSTY----YAALVAIIG 154
            :.:.:.|.|::|:|:.:|||:..|:..|:.:||.:||||    |.|.::|.|    |..::|...
Mouse   104 LFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVG----FTVILISFYVGFFYNVIIAWAL 164

  Fly   155 RYFIESFRNPLPWSTCRAEWGIHCINSAPDASNWSQLESNDQRPQNYTMKSQNDRVITSSEWYFV 219
            .||..||...|||..|...|      ::|:.|:.....|:|....|.|..:      |.:..||.
Mouse   165 HYFFSSFTMDLPWIHCNNTW------NSPNCSDAHSSNSSDGLGLNDTFGT------TPAAEYFE 217

  Fly   220 KEV--LHEKPNIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLV 282
            :.|  ||:...|:: :|.|.|:|...|.:....::|.:.:|||:|||..:..|..|||::..||:
Mouse   218 RGVLHLHQSRGIDD-LGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLL 281

  Fly   283 RAVTLPGSIDGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAA 347
            |.|||||::|||..::...:.::.:..||..|.||..:||.|.||.:|.:||:|||.:|.:|||.
Mouse   282 RGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAI 346

  Fly   348 IVTGLDTMTSLLAGFTIFGILGHLA--HEIGTDDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFS 410
            |.|.::::||..:||.:|..||::|  |.:...|:.:   .|.||.||.||:|||... |...::
Mouse   347 ITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVAT---DGPGLIFIIYPEAIATLP-LSSAWA 407

  Fly   411 VLFFLMLFVLGIGSNIAMTSCSVTAIRDRFPNFGQWQ--CSLLIAVVSFFIGLMYITPGGQYMLT 473
            .:|||||..|||.|.:......:|.:.|.|....:.:  .:|.|.:.:|.:.|..:|.||.|:.|
Mouse   408 AVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFT 472

  Fly   474 LVDFFGASMIALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIY 538
            |:|.|.|....|...:.|...:.|.||..:...||:.|.|::..|||||||.:::|..:..:::.
Mouse   473 LLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVV 537

  Fly   539 FYATYQPLTYNNIVYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPKKN 601
            ...|::|..|...::|:|:.::||:|....:..:||:........|| :...|:..|.||:|:
Mouse   538 SIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPG-SFREKLAYAITPEKD 599

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG15279NP_609726.1 SLC5-6-like_sbd 50..598 CDD:294310 195/557 (35%)
Slc6a3NP_034150.1 SLC5-6-like_sbd 60..613 CDD:294310 198/562 (35%)
Interaction with TGFB1I1. /evidence=ECO:0000250 560..589 7/29 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0733
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D250396at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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