DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15279 and slc6a13

DIOPT Version :9

Sequence 1:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_002667408.5	Gene:	slc6a13 / 100332592	ZFINID:	ZDB-GENE-170607-2	Length:	621	Species:	Danio rerio

Alignment Length:	580	Identity:	210/580 - (36%)
Similarity:	323/580 - (55%)	Gaps:	37/580 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 EERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIVLFLIGKPIYYLEMVIGQ 112
            ::|..|...:||::|.....:|||||||||:....||||||.|||||.||..|.|:::||:.:||
Zfish    28 KDRGQWSNKLEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLEISLGQ 92

  Fly   113 FSSRGSVKVF-DLCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYFIESFRNPLPWSTCRAEWGI 176
            ::|.|.:..: .:.|..:|:|......|.:|:.||..::|....|...||...||||:|...|..
Zfish    93 YTSEGGITCWRKISPLFEGIGYATQVIVALLNFYYIIVLAWGIFYLSNSFTWNLPWSSCNNTWNT 157

  Fly   177 H-CINSAPDASNWSQLESNDQRPQNYTMKSQNDRVITSSEWYFVKEVLHEKPNIEEGIGLPNWEL 240
            . |:...         ..||...|:| :.:....||.    ::.:.||.....||: ||..:|:|
Zfish   158 ESCMEFQ---------RRNDSVDQSY-LDNATSPVIE----FWERRVLRISSGIED-IGTLHWDL 207

  Fly   241 VIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRAVTLPGSIDGIYYFIKPQWGKI 305
            |:.|.:||...:|.|.:||||:||..||.|.||||::.:||:|.|||||:..||.:::.|..|::
Zfish   208 VLCLLLAWVLCYFCIWKGVKSTGKVVYFTATFPYVMLLILLIRGVTLPGASRGIQFYLYPDLGRL 272

  Fly   306 LDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIVTGLDTMTSLLAGFTIFGILGH 370
            .||:||..|.||.|:|.::|.|.:....|:||:.:|.:||:..:..|::.||.:|||.||.|||.
Zfish   273 ADPQVWMDAGTQIFFSYAICLGCLTALGSYNKYNNNCYRDSLALCFLNSGTSFVAGFAIFSILGF 337

  Fly   371 LAHEIGTDDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFSVLFFLMLFVLGIGSNIAMTSCSVTA 435
            :::|... .|..|.:.|.|||||:||.|::.....| :::..||:|:.:||:.|........|||
Zfish   338 MSYEQNV-PISEVAESGPGLAFIAYPRAVSMMPISP-LWACFFFIMIVLLGLDSQFVCVESLVTA 400

  Fly   436 IRDRFPNFGQWQ-----CSLLIAVVSFFIGLMYITPGGQYMLTLVDFFGAS-MIALVLGIAELYT 494
            :.|.:|:|.:.:     ..|::|:|||.:||:.:|.||.|:..|.|::.|| |..|.:.|.|...
Zfish   401 MVDMYPSFFRRKNRRELLILVVAIVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFETVC 465

  Fly   495 IGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIYFYATYQPLTYNN-IVYPNWSY 558
            |.||||.:|...:||.|:|.:.|.|.:.||...||........:....|.||.||| .|||.|.|
Zfish   466 IAWIYGANRFYDNIEDMIGYRPGPYIKYCWLFFTPATCFGTFAFSLIKYTPLKYNNEYVYPWWGY 530

  Fly   559 SIGWLITAFGILQLPIWMIVAIVRDPGQTLGA---KIRGAFTPKKNWGPSDPLLREQYHK 615
            ::||::....::.:|:|:|..:    |.|.|:   :::....|    .|..|..|.:..|
Zfish   531 ALGWMLALSSMICVPLWVIYRM----GTTKGSLMERVQFLIRP----SPDLPKSRREQEK 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	205/559 (37%)
slc6a13	XP_002667408.5	SLC6sbd-TauT-like	30..569	CDD:271387	205/559 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820