Protein Alignment CG42685 and Pkd1l2

DIOPT Version :9

• Sequence 1: NP_609717.5
• Gene: CG42685 / 34854
• FlyBaseID: FBgn0261571
• Length: 1609
• Species: Drosophila melanogaster
• Sequence 2: XP_036010263.1
• Gene: Pkd1l2 / 76645
• MGIID: 2664668
• Length: 2466
• Species: Mus musculus
• Alignment Length: 1140
• Identity: 207/1140 - (18%)
• Similarity: 353/1140 - (30%)
• Gaps: 351/1140 - (30%)

  Fly   555 TLRLPPYALKENAVYDFSLTVISRFDPRNRMTTTQTIKGVAKTTFTPQILCRRNCALGVYAPLDS 619
            |..|||.    |:.....|.::...:....  |.|.:...|.....|||.|.:||. .|.|..|.
Mouse   627 TFCLPPL----NSAVTLHLAILRGQELEKE--TEQCLYVSAPLNLGPQISCEKNCR-PVKADQDV 684

  Fly   620 IHLISKCDDCPGTVKRYEWWLLDT---ESQP----------------TLESSHKYLILH-----T 660
            :..::..|:.  :|..:.|:|.||   |::|                .|.|:...|:|:     |
Mouse   685 LLTVTVGDET--SVAVFSWYLDDTVPEEAEPLPAACRLRGFWPRSLTLLHSNSSVLLLNSSFLQT 747

  Fly   661 LEPLVQIRLRVWVKGQGWADAFYTLRRNNGPQHGSCTIYPFLGVEG--FTMFEIDCPGFESPFPP 723
            ..|::.||:.. :....:.:..|.:.....|:..:|||.|   .||  .|.|.:.| ...:...|
Mouse   748 WGPVIPIRVTA-LTSHAYGEDTYMISMLPRPEVPACTIDP---EEGSVLTSFTVSC-STPATLGP 807

  Fly   724 ITYRYMVSYGVVASNVPYSRI-VLTLPAAE-------TIMISICDAIDMCVEKRVEVKVLSIDKS 780
            :.|.:.:..|......|...: .:.||..|       .::||:.:......:.:|.|||
Mouse   808 VEYCFCLPSGFCLHCGPEPALPAVYLPLGEEKDGFVLPVVISVTNRAGDIEQTQVAVKV------ 866

  Fly   781 MLTGQKEVMNYVPNFFKRGHWNRAYIMGIAAITF-------IETSI---DGDE--------FYSY 827
                              ||   :| .|:..:||       |.|::   .|.|        ..|.
Mouse   867 ------------------GH---SY-TGVEDVTFQEMVSERIATALHQESGREQLLLFAKAVSSE 909

  Fly   828 LTGLVASTGS---QMEQITTLSSHMLIRLHPV-----DFRGATVMAEMFSHLGDSFSAIVQEHEW 884
            |...|.|.||   .|:....:...||..|..|     :.:....:||:...:......:....:|
Mouse   910 LNSEVQSPGSGQLGMDIKRKVRELMLRSLSVVTTGLQNMQRVQALAEVLREVTQRAEELTPAAQW 974

  Fly   885 -----LHR--------------EGYYSLTAMHMFFMSI-------LGKKTESHSNAMCSLHNPAC 923
                 |.|              |......|....|.::       |..::|....|..|......
Mouse   975 EASCALQRATEALLVASTKVRPEDQRRQEATRAMFEAVGSVLEASLSHRSEEPMEANSSQAYIVA 1039

  Fly   924 MNLQIIDLEKPFVIKFDPLILVRINSWLMSTWFLYRCIYFLGVIATQRHHPYDDALTIHKSGIAY 988
            ..|::||       .|...:|                   ||.:....     .|:.:..|...|
Mouse  1040 QLLRVID-------HFQSALL-------------------LGTLPGGL-----PAILVTPSISVY 1073

  Fly   989 QINVTEVTENTKDIQVKTIDHIHVIKLSTKLLYELQRRLNHSSILLQIISQQNFHNIYWWYPDPF 1053
            ...:...:.....:.....|.:.....:...|..::.......|.:...||           :||
Mouse  1074 TDRIQPRSWQGSSVHTAAADSVTFTLPAATFLCPMEDSQEPVDIRMMSFSQ-----------NPF 1127

  Fly  1054 PSKTSVLIVHAYSPVQFFRSAKEFQLTNPLVYKTNITHFNDASFNQYMTNNSIQN------STEV 1112
            ||::...:......::...|:     .:|:..|                 |..||      ....
Mouse  1128 PSRSQFDVSGTVGGLRLTSSS-----GHPIPVK-----------------NLSQNIEILLPRISA 1170

  Fly  1113 HIYSVMLNHKAMLAVRIVNCSELMYIKMRLHRWPTLGQIRQHACRITPDMQGKRIWIANSCERSP 1177
            ||...||:..:..|:.:...:....:.::||..|.:                            |
Mouse  1171 HIEPKMLSLASREALSVNVTAGDTALGIQLHWGPGV----------------------------P 1207

  Fly  1178 AYVAI---HKPGEIRYKTEDKDQLSARGRKKGNRTHDGSETPEVRQKADFIDY--DNEDI----- 1232
            ..:::   :.|.|..|..:               ||    .|.|....|...:  ..||:
Mouse  1208 LILSLGYGYHPNETSYDAQ---------------TH----LPPVAATGDLPTWILHPEDLPFGEG 1253

  Fly  1233 --VEEVLP-----------LNYSILLEIYQCNIWKNRSLDPGWSEDHCTTSFEHSRGSSVQCTCH 1284
              ...|:|           |...|...:..|..|.  .....|.:..|... ..:..|...|.|:
Mouse  1254 VYYLRVVPEADLESSSGRNLTVGITTFLAHCVFWD--ETQETWDDSGCQVG-PRTTPSQTHCLCN 1315

  Fly  1285 TLGALSSRIFPI--------SSQLFV--EHIPVPIFTFNMILMIFFALLFLLLVFKFLLHLNIIS 1339
            .|....|....:        :::||.  |..||.:.|...:.|::..:|              |.
Mouse  1316 HLTFFGSSFLVMPNAIDVRQTAELFATFEDNPVVVTTVGCLCMLYVLVL--------------IW 1366

  Fly  1340 AYLKNPEFRLQCDASVGKSDQSFVSGSEILLVIVTGGQEFAGTTSNVKFYLKSPHRQQTSYQITQ 1404
            |..|:.:.:.:....|.:.:..|.. ...|:.:.||.:..|.|:|.|...|.....:...:.::
Mouse  1367 ARRKDIQDQAKVKVVVLEDNDPFAQ-YHYLVTVYTGHRRGAATSSKVTLTLYGSDGESEPHHLS- 1429

  Fly  1405 DPGHPKLLRNST----IKIMVPRGHIYIPTRLALRL--VPNGRYPSWYCRSITVVDLKLKVQQLF 1463
            ||......|...    :..:.|.|.:.     :|||  ..:|..||||...:.|.|..:..:..|
Mouse  1430 DPDAAVFERGGVDVFLLSTLFPLGELQ-----SLRLWHDNSGDRPSWYVSRVLVYDSVVDRKWYF 1489

  Fly  1464 LVESW--IEGG-------------------SHIQFMR-SKYFTYGN--YSRYPKYTWCKRFRS-- 1502
            |..||  ::.|                   ||:.|.: |..|..|:  ||     .:|...||
Mouse  1490 LCNSWLSVDVGDCVLDKVFPVATEQDRKQFSHLFFTKTSTGFQDGHIWYS-----VFCSATRSSF 1549

  Fly  1503 -RAEQL--YFSWYLINAITG---------PSQSKV 1525
             |.:::  .||..|...:|.         |::.|:
Mouse  1550 TRVQRVSCCFSMLLCTMLTSIMFWGVPKDPAEQKM 1584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..753	CDD:307914	52/231 (23%)
		PLAT	1367..1480	CDD:238061	31/140 (22%)
Pkd1l2	XP_036010263.1	CLECT	28..154	CDD:214480
		Gal_Lectin	170..252	CDD:396628
		REJ	493..866	CDD:366875	56/252 (22%)
		GPS	1282..1321	CDD:396408	8/41 (20%)
		PLAT_polycystin	1392..1511	CDD:238850	28/124 (23%)
		PKD_channel	1987..2407	CDD:400395

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11148
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010