Protein Alignment CG42685 and Pkd1l2

DIOPT Version :10

• Sequence 1: NP_609717.5
• Gene: CG42685 / 34854
• FlyBaseID: FBgn0261571
• Length: 1609
• Species: Drosophila melanogaster
• Sequence 2: XP_038954049.1
• Gene: Pkd1l2 / 691069
• RGDID: 1588631
• Length: 2492
• Species: Rattus norvegicus
• Alignment Length: 1146
• Identity: 215/1146 - (18%)
• Similarity: 368/1146 - (32%)
• Gaps: 365/1146 - (31%)

  Fly   555 TLRLPPYALKENAVYDFSLTVISRFDPRNRMTTTQTIKGVAKTTFTPQILCRRNCALGVYAPLDS 619
            |..|||.    |:.....|.:: |.....| .|.:.:...|.....|||.|::||. .|.|..|.
  Rat   655 TFCLPPL----NSAVTLHLAIL-RGQELER-ETERCLYVSAPLDLGPQISCQKNCR-PVKADQDV 712

  Fly   620 IHLISKCDDCPGTVKRYEWWLLDT---ESQP----------------TLESSHKYLILH-----T 660
            :..::..|:.|  |..:.|:|.||   :::|                .|.|:...|:|:     |
  Rat   713 LLTVTVGDETP--VAMFNWYLDDTSPEKAEPLPAACRLRGFWPRSLTLLHSNSSVLLLNSSFLQT 775

  Fly   661 LEPLVQIRLRVWVKGQGWADAFYTLRRNNGPQHGSCTIYPFLGVEG--FTMFEIDC-----PGFE 718
            ..|::.||:.. :....:.:..:.:.....|:..:|.|.|   .||  .|.|.|.|     ||
  Rat   776 WGPVIHIRVTA-LTDHAYGEDTHVISMLPPPEVPACVIDP---EEGSVLTSFAIFCSTPTAPG-- 834

  Fly   719 SPFPPITYRYMVSYGVVASNVPYSRI-VLTLPAAE-------TIMISICDAIDMCVEKRVEVKVL 775
                |:.|.:.|..|......|...: .:.||..|       |::||:.|......:..:.|||.
  Rat   835 ----PVEYCFCVQSGSCLHCGPEPALPAVYLPRGEEKDGFVLTVVISVTDQAGDREQTHMAVKVG 895

  Fly   776 SIDKSM--LTGQKEVMNYVPN--FFKRGHWNRAYI------------------------------ 806
            ..|..:  :|.|:.|.:.:..  :.:.||.....:
  Rat   896 HDDTGVEDVTFQETVSDRITTALYHEHGHEELLLLAKAVSSELNKEDQGPGSGRLRMDIKRKVRE 960

  Fly   807 MGIAAITFIETSIDGDEFYSYLTGLVASTGSQMEQITTLS-------------SHMLIRLHPVDF 858
            :.:.:::.:.|.::..:....|...:.......|::|.::             :.:..::||.|.
  Rat   961 LVLRSLSTVTTGLENMQRVQALAEALREVTHHSEELTLVAQWEASQALQRNTEALLAAKVHPKDQ 1025

  Fly   859 RGATVMAEMFSHLGDSFSAIVQEHEWLHREGYYSLTAMHMFFMSILGKKTESHSNAMCSLHNPAC 923
            |.......||..:|....|                         .|...::..:.|..|..:...
  Rat  1026 RRQEATRAMFEAVGSVLKA-------------------------SLSHGSDEPAEANSSQAHIVA 1065

  Fly   924 MNLQIIDLEKPFVIKFDPLILVRINSWLMSTWFLYRCIYFLG--------VIATQRHHPYDDALT 980
            ..||::|               |:.|.|:           ||        ::||.....|.|.:.
  Rat  1066 QLLQVVD---------------RLQSALL-----------LGTLPGGLPAILATSSVSVYTDRIQ 1104

  Fly   981 IHKSGIAYQINVTEVTENTKDIQVKTIDHIHVIKLSTKLLYELQRRLNHSSILLQIISQQNFHNI 1045
             .:|.....::.|            ..|.:..|..:|..|...:.......|.:...||
  Rat  1105 -PRSWQGSSVHTT------------AADSVIFILPATTFLCPTEDSQEPVDIRMMSFSQ------ 1150

  Fly  1046 YWWYPDPFPSKTSVLIVHAYSPVQFFRSAKEFQLTNPLVYKTNITHFNDASFNQYMTNNSIQN-- 1108
                 :||||::...:......::...|:     ..|:..|                 |..||
  Rat  1151 -----NPFPSRSHFEVSGTVGGLRLTSSS-----GRPIPVK-----------------NLSQNIE 1188

  Fly  1109 ------STEVHIYSVMLNHKAMLAVRIVNCSELMYIKMRLHRWP------TLGQIRQHACRITPD 1161
                  ||.:...::.|.....|:|.:......:.|  :||..|      :|| ...|....:.|
  Rat  1189 ILLPRISTRIKPNTLSLATGDALSVNVTAGDAALGI--QLHWGPGVALTLSLG-YGYHPNETSYD 1250

  Fly  1162 MQGKRIWIANSCERSPAYVAIHKP---GEIRY--KTEDKDQLSARGRKKGNRTHDGSETPEVRQK 1221
            .|.:...:|::.: .|.::...:.   ||..|  :...||.|.:        |.|.:
  Rat  1251 AQTRLPAVADAGD-LPTWILYPEDLPFGEGIYYLRVVPKDDLES--------TSDRN-------- 1298

  Fly  1222 ADFIDYDNEDIVEEVLPLNYSILLEIYQCNIWKNRSLDPGWSEDHC------TTSFEHSRGSSVQ 1280
                             |...|...:..|..|.  .....|....|      |||..|
  Rat  1299 -----------------LTVGITTFLAHCVFWD--EAQGTWDNSGCRVGPRTTTSQTH------- 1337

  Fly  1281 CTCHTLGALSSRIFPI--------SSQLFV--EHIPVPIFTFNMILMIFFALLFLLLVFKFLLHL 1335
            |.|:.|....|....:        :::||.  |..||.:.|...:.|::.              |
  Rat  1338 CLCNHLTFFGSTFLVMPNAIDVHQTAELFATFEDNPVVVTTVGCLCMVYV--------------L 1388

  Fly  1336 NIISAYLKNPEFRLQCDASVGKSDQSFVSGSEILLVIVTGGQEFAGTTSNVKFYL------KSPH 1394
            .:|.|..|:.:.:.:....|.:.:..|.. ...|:.:.||.:..|.|:|.|...|      ..||
  Rat  1389 VVIWARRKDIQDQAKAKVIVLEDNDPFAQ-YHYLVTVYTGHRRGAATSSKVTLTLYGSDGESEPH 1452

  Fly  1395 RQQTSYQITQDPGHPKLLRNSTIKIMVPRGHIYIPTRLALRL--VPNGRYPSWYCRSITVVDLKL 1457
            ....|.....:.|...:...||   :.|.|.:.     :|||  ..:|..||||...:.|.|..:
  Rat  1453 HLSDSDAAVFERGGVDVFLLST---LFPLGELQ-----SLRLWHDNSGDRPSWYVSRVLVYDPVV 1509

  Fly  1458 KVQQLFLVESW--IEGG-------------------SHIQFMR-SKYFTYGN--YSRYPKYTWCK 1498
            ..:..||..||  |:.|                   ||:.|.: |..|..|:  ||     .:|.
  Rat  1510 DQKWYFLCNSWLSIDVGDCVLDKVFPVATEQDRKQFSHLFFTKTSTGFQDGHIWYS-----VFCN 1569

  Fly  1499 RFRS---RAEQL--YFSWYLINAITG---------PSQSKV 1525
            ..||   |.:::  .||..|...:|.         |::.|:
  Rat  1570 STRSSFTRVQRVSCCFSMLLCTMLTSIMFWGVPKDPAEQKM 1610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..>728	CDD:366875	49/203 (24%)
		PLAT	1367..1480	CDD:238061	35/142 (25%)
Pkd1l2	XP_038954049.1	CLECT	70..186	CDD:153057
		Gal_Rha_Lectin_PKD1L2	189..285	CDD:438688
		REJ	<697..894	CDD:366875	48/209 (23%)
		GPS	1308..1347	CDD:460350	11/47 (23%)
		PLAT_polycystin	1418..1537	CDD:238850	32/126 (25%)
		Polycystin_dom	2013..2209	CDD:466668
		PKD_channel	2211..2433	CDD:462341