Protein Alignment CG42685 and PKD1

DIOPT Version :10

• Sequence 1: NP_609717.5
• Gene: CG42685 / 34854
• FlyBaseID: FBgn0261571
• Length: 1609
• Species: Drosophila melanogaster
• Sequence 2: XP_047290164.1
• Gene: PKD1 / 5310
• HGNCID: 9008
• Length: 4348
• Species: Homo sapiens
• Alignment Length: 1413
• Identity: 273/1413 - (19%)
• Similarity: 418/1413 - (29%)
• Gaps: 534/1413 - (37%)

  Fly   312 LRKLMRKWGIRSKRIVYNRCYFH----RCTARFYNTKHKYIVAKVSSLNDRRKLLAHVVRFKIKV 372
            |:.|||    ||:|   |....|    .|..  |.|::::.|.:.:|. .|....|.|....:.|
Human  2202 LQVLMR----RSQR---NYLEAHVDLRDCVT--YQTEYRWEVYRTASC-QRPGRPARVALPGVDV 2256

  Fly   373 RKPPNVSCLPALELEFCKNPEKPVYFSPMGH--LEFFASISDACSTVEYDKITWQLCDITENKII 435
            .:|..|  ||.|.|             |:||  ..|..|..|.              .:|::
Human  2257 SRPRLV--LPRLAL-------------PVGHYCFVFVVSFGDT--------------PLTQS--- 2289

  Fly   436 ARLKNATGLVVKLLPYKVHILNEPDRRKVFLLRGKAVINGVTTVARCYMKYKPPPIEPLIKGNER 500
                                                 |....|||       |..:.|:|:|...
Human  2290 -------------------------------------IQANVTVA-------PERLVPIIEGGSY 2310

  Fly   501 RLVDVRKPIIIDGSSSKDRLKIRESIKSK-QFLWTCISLDDPFNNYCKKYMSK--SPTLRLPPYA 562
            |:....:.:::|||.|.|. .:.:..::. .|.|.|::........|......  |.|:.:|...
Human  2311 RVWSDTRDLVLDGSESYDP-NLEDGDQTPLSFHWACVASTQREAGGCALNFGPRGSSTVTIPRER 2374

  Fly   563 LKENAVYDFSLTVISRFDPRNRMTTTQTI---KGVAKTTFTPQILCRRNCALGVYAPLDS--IHL 622
            |.....|.|||||...  .|....|.||:   .|.........:.|:   |..||....|  ::|
Human  2375 LAAGVEYTFSLTVWKA--GRKEEATNQTVLIRSGRVPIVSLECVSCK---AQAVYEVSRSSYVYL 2434

  Fly   623 ISKCDDCPGTVKRYEW---------WLLDTESQPTLESSHKYLILHTLEPLVQIRLRVWVKGQGW 678
            ..:|.:|....||..|         .:|| |:..:..|:...|:|         |..|...|:|:
Human  2435 EGRCLNCSSGSKRGRWAARTFSNKTLVLD-ETTTSTGSAGMRLVL---------RRGVLRDGEGY 2489

  Fly   679 ADAFYTLRR--------------NNGPQHGSCTIYPFLGVEGF-TMFEIDCPGF---ESPFPPIT 725
            ......|.|              |..|..|||.::|...|... |....:|.|:   |....|:.
Human  2490 TFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLGAVHALTTKVHFECTGWHDAEDAGAPLV 2554

  Fly   726 YRYMV-------------------SYGVVASNVPYSRIVLTLPAAETIMISICDAIDMCVEKRVE 771
            |..::                   |||.|            ||........:  .:.:.|:.::.
Human  2555 YALLLRRCRQGHCEEFCVYKGSLSSYGAV------------LPPGFRPHFEV--GLAVVVQDQLG 2605

  Fly   772 VKVLSIDKSMLTGQKEVMNYVPNFFKRGHWNRAYIMGIAAITFIETSIDGDEFYSYLTGLVASTG 836
            ..|:::::|:.....|     ||....|  ...::.|:.|              |.|.||:....
Human  2606 AAVVALNRSLAITLPE-----PNGSATG--LTVWLHGLTA--------------SVLPGLLRQAD 2649

  Fly   837 SQ------MEQITTLSSHMLIRLHPVDFRGATVMAEMFSHLGDSFSAIVQEHEWLHREGYYSLTA 895
            .|      :..:|.|:.:.         |...|.||             .:||..||
Human  2650 PQHVIEYSLALVTVLNEYE---------RALDVAAE-------------PKHERQHR-------- 2684

  Fly   896 MHMFFMSILGKKTESHSNAMCSLHNPACMNLQIIDLEKPFVIKFDPLILVRINSWLMSTWFLYRC 960
                 ..|....||:                               |:.:|:
Human  2685 -----AQIRKNITET-------------------------------LVSLRV------------- 2700

  Fly   961 IYFLGVIATQRHHPYDD------AL------------------TIHKSGIAYQINVTEVTENT-- 999
                        |..||      ||                  |:||......|...|.|..|
Human  2701 ------------HTVDDIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVT 2753

  Fly  1000 -----KDIQVKTIDHIHV--------------------------IKLSTKLLYELQRR--LNHSS 1031
                 ..|...|.|.||:                          ..|::.|:..|.|.  ||...
Human  2754 PTAIGDSILNITGDLIHLASSDVRAPQPSELGAESPSRMVASQAYNLTSALMRILMRSRVLNEEP 2818

  Fly  1032 ILL---QIISQQNFHN-----IYWWYPDP-----FPSKTSVLIVHAYSPVQ--FFRSAKEFQLTN 1081
            :.|   :|::|....:     .|...|.|     .|...|..:.:....||  |...:..|
Human  2819 LTLAGEEIVAQGKRSDPRSLLCYGGAPGPGCHFSIPEAFSGALANLSDVVQLIFLVDSNPF---- 2879

  Fly  1082 PLVYKTNITHFNDASFNQYMTNNSIQNSTEVHIYSVMLNHKAMLAVRIVNCSELMYIKMRLHRWP 1146
            |..|.:|.|.....:...:.|....|...|      .|..:..:.|::.|.|:          |.
Human  2880 PFGYISNYTVSTKVASMAFQTQAGAQIPIE------RLASERAITVKVPNNSD----------WA 2928

  Fly  1147 TLGQIRQ----HACRITPDMQ-GKRIWIANS--------------------CERSPAYVAIHKPG 1186
            ..|....    ::..:.|... |..:.:.:|                    .|....|:|::...
Human  2929 ARGHRSSANSANSVVVQPQASVGAVVTLDSSNPAAGLHLQLNYTLLDGHYLSEEPEPYLAVYLHS 2993

  Fly  1187 EIRYKTEDKDQLSARGRKKGNRTHDGSETPEVRQKAD------FIDYDNEDIVEEVLP------- 1238
            |.|   .::...||..|.:          ||..|.||      ||...:.|      |
Human  2994 EPR---PNEHNCSASRRIR----------PESLQGADHRPYTFFISPGSRD------PAGSYHLN 3039

  Fly  1239 ---------LNYSILLEIYQCN-------IWKNRSLDPGWSEDHCTTSFEHSRGSSVQCTCHTLG 1287
                     |..|:.|....|.       :|:...|.|          .|.:......|....|.
Human  3040 LSSHFRWSALQVSVGLYTSLCQYFSEEDMVWRTEGLLP----------LEETSPRQAVCLTRHLT 3094

  Fly  1288 ALSSRIF-PISSQLFVEHIPVPIFTFNMILMIFFAL-LFLLLVFKFLLHLNIISAYLKNPEFRL- 1349
            |..:.:| |.|...||  .|.|....|.|:|:..|: |...:|...:||             :|
Human  3095 AFGASLFVPPSHVRFV--FPEPTADVNYIVMLTCAVCLVTYMVMAAILH-------------KLD 3144

  Fly  1350 QCDASVGKS----DQSFVSGSEILLVIVTGGQEFAGTTSNVKFYLKSPHRQQTSYQITQDPGHPK 1410
            |.|||.|::    .|......|||  :.||....:|||::|...|         |.:....||..
Human  3145 QLDASRGRAIPFCGQRGRFKYEIL--VKTGWGRGSGTTAHVGIML---------YGVDSRSGHRH 3198

  Fly  1411 L------LRNS--TIKIMVPR--GHIYIPTRLALRLVPNGRYPSWYCRSITVVDLKLKVQQLFLV 1465
            |      .|||  ..:|..|.  |.::   ::.:.....|..|:|:.:.:.|.||:......|||
Human  3199 LDGDRAFHRNSLDIFRIATPHSLGSVW---KIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLV 3260

  Fly  1466 ESWI------EGG---------SHIQFMRSKYFTYGNYSR--YPKYTW 1496
            ..|:      .||         |....:|.:........|  :.|:.|
Human  3261 NDWLSVETEANGGLVEKEVLAASDAALLRFRRLLVAELQRGFFDKHIW 3308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..>728	CDD:366875	71/351 (20%)
		PLAT	1367..1480	CDD:238061	33/137 (24%)
PKD1	XP_047290164.1	PPP1R42	<54..127	CDD:455733
		leucine-rich repeat	70..92	CDD:275378
		leucine-rich repeat	93..116	CDD:275378
		PCC	97..2773	CDD:188093	152/798 (19%)
		leucine-rich repeat	117..129	CDD:275378
		GPS	3056..3105	CDD:470616	10/58 (17%)
		PLAT_polycystin	3163..3282	CDD:238850	32/132 (24%)
		Polycystin_dom	3758..3936	CDD:466668
		PKD_channel	3937..4158	CDD:462341