DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42685 and PKD1

DIOPT Version :9

Sequence 1:NP_609717.5 Gene:CG42685 / 34854 FlyBaseID:FBgn0261571 Length:1609 Species:Drosophila melanogaster
Sequence 2:XP_024306066.1 Gene:PKD1 / 5310 HGNCID:9008 Length:4343 Species:Homo sapiens


Alignment Length:1413 Identity:273/1413 - (19%)
Similarity:418/1413 - (29%) Gaps:534/1413 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   312 LRKLMRKWGIRSKRIVYNRCYFH----RCTARFYNTKHKYIVAKVSSLNDRRKLLAHVVRFKIKV 372
            |:.|||    ||:|   |....|    .|..  |.|::::.|.:.:|. .|....|.|....:.|
Human  2197 LQVLMR----RSQR---NYLEAHVDLRDCVT--YQTEYRWEVYRTASC-QRPGRPARVALPGVDV 2251

  Fly   373 RKPPNVSCLPALELEFCKNPEKPVYFSPMGH--LEFFASISDACSTVEYDKITWQLCDITENKII 435
            .:|..|  ||.|.|             |:||  ..|..|..|.              .:|::   
Human  2252 SRPRLV--LPRLAL-------------PVGHYCFVFVVSFGDT--------------PLTQS--- 2284

  Fly   436 ARLKNATGLVVKLLPYKVHILNEPDRRKVFLLRGKAVINGVTTVARCYMKYKPPPIEPLIKGNER 500
                                                 |....|||       |..:.|:|:|...
Human  2285 -------------------------------------IQANVTVA-------PERLVPIIEGGSY 2305

  Fly   501 RLVDVRKPIIIDGSSSKDRLKIRESIKSK-QFLWTCISLDDPFNNYCKKYMSK--SPTLRLPPYA 562
            |:....:.:::|||.|.|. .:.:..::. .|.|.|::........|......  |.|:.:|...
Human  2306 RVWSDTRDLVLDGSESYDP-NLEDGDQTPLSFHWACVASTQREAGGCALNFGPRGSSTVTIPRER 2369

  Fly   563 LKENAVYDFSLTVISRFDPRNRMTTTQTI---KGVAKTTFTPQILCRRNCALGVYAPLDS--IHL 622
            |.....|.|||||...  .|....|.||:   .|.........:.|:   |..||....|  ::|
Human  2370 LAAGVEYTFSLTVWKA--GRKEEATNQTVLIRSGRVPIVSLECVSCK---AQAVYEVSRSSYVYL 2429

  Fly   623 ISKCDDCPGTVKRYEW---------WLLDTESQPTLESSHKYLILHTLEPLVQIRLRVWVKGQGW 678
            ..:|.:|....||..|         .:|| |:..:..|:...|:|         |..|...|:|:
Human  2430 EGRCLNCSSGSKRGRWAARTFSNKTLVLD-ETTTSTGSAGMRLVL---------RRGVLRDGEGY 2484

  Fly   679 ADAFYTLRR--------------NNGPQHGSCTIYPFLGVEGF-TMFEIDCPGF---ESPFPPIT 725
            ......|.|              |..|..|||.::|...|... |....:|.|:   |....|:.
Human  2485 TFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLGAVHALTTKVHFECTGWHDAEDAGAPLV 2549

  Fly   726 YRYMV-------------------SYGVVASNVPYSRIVLTLPAAETIMISICDAIDMCVEKRVE 771
            |..::                   |||.|            ||........:  .:.:.|:.::.
Human  2550 YALLLRRCRQGHCEEFCVYKGSLSSYGAV------------LPPGFRPHFEV--GLAVVVQDQLG 2600

  Fly   772 VKVLSIDKSMLTGQKEVMNYVPNFFKRGHWNRAYIMGIAAITFIETSIDGDEFYSYLTGLVASTG 836
            ..|:::::|:.....|     ||....|  ...::.|:.|              |.|.||:....
Human  2601 AAVVALNRSLAITLPE-----PNGSATG--LTVWLHGLTA--------------SVLPGLLRQAD 2644

  Fly   837 SQ------MEQITTLSSHMLIRLHPVDFRGATVMAEMFSHLGDSFSAIVQEHEWLHREGYYSLTA 895
            .|      :..:|.|:.:.         |...|.||             .:||..||        
Human  2645 PQHVIEYSLALVTVLNEYE---------RALDVAAE-------------PKHERQHR-------- 2679

  Fly   896 MHMFFMSILGKKTESHSNAMCSLHNPACMNLQIIDLEKPFVIKFDPLILVRINSWLMSTWFLYRC 960
                 ..|....||:                               |:.:|:             
Human  2680 -----AQIRKNITET-------------------------------LVSLRV------------- 2695

  Fly   961 IYFLGVIATQRHHPYDD------AL------------------TIHKSGIAYQINVTEVTENT-- 999
                        |..||      ||                  |:||......|...|.|..|  
Human  2696 ------------HTVDDIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVT 2748

  Fly  1000 -----KDIQVKTIDHIHV--------------------------IKLSTKLLYELQRR--LNHSS 1031
                 ..|...|.|.||:                          ..|::.|:..|.|.  ||...
Human  2749 PTAIGDSILNITGDLIHLASSDVRAPQPSELGAESPSRMVASQAYNLTSALMRILMRSRVLNEEP 2813

  Fly  1032 ILL---QIISQQNFHN-----IYWWYPDP-----FPSKTSVLIVHAYSPVQ--FFRSAKEFQLTN 1081
            :.|   :|::|....:     .|...|.|     .|...|..:.:....||  |...:..|    
Human  2814 LTLAGEEIVAQGKRSDPRSLLCYGGAPGPGCHFSIPEAFSGALANLSDVVQLIFLVDSNPF---- 2874

  Fly  1082 PLVYKTNITHFNDASFNQYMTNNSIQNSTEVHIYSVMLNHKAMLAVRIVNCSELMYIKMRLHRWP 1146
            |..|.:|.|.....:...:.|....|...|      .|..:..:.|::.|.|:          |.
Human  2875 PFGYISNYTVSTKVASMAFQTQAGAQIPIE------RLASERAITVKVPNNSD----------WA 2923

  Fly  1147 TLGQIRQ----HACRITPDMQ-GKRIWIANS--------------------CERSPAYVAIHKPG 1186
            ..|....    ::..:.|... |..:.:.:|                    .|....|:|::...
Human  2924 ARGHRSSANSANSVVVQPQASVGAVVTLDSSNPAAGLHLQLNYTLLDGHYLSEEPEPYLAVYLHS 2988

  Fly  1187 EIRYKTEDKDQLSARGRKKGNRTHDGSETPEVRQKAD------FIDYDNEDIVEEVLP------- 1238
            |.|   .::...||..|.:          ||..|.||      ||...:.|      |       
Human  2989 EPR---PNEHNCSASRRIR----------PESLQGADHRPYTFFISPGSRD------PAGSYHLN 3034

  Fly  1239 ---------LNYSILLEIYQCN-------IWKNRSLDPGWSEDHCTTSFEHSRGSSVQCTCHTLG 1287
                     |..|:.|....|.       :|:...|.|          .|.:......|....|.
Human  3035 LSSHFRWSALQVSVGLYTSLCQYFSEEDMVWRTEGLLP----------LEETSPRQAVCLTRHLT 3089

  Fly  1288 ALSSRIF-PISSQLFVEHIPVPIFTFNMILMIFFAL-LFLLLVFKFLLHLNIISAYLKNPEFRL- 1349
            |..:.:| |.|...||  .|.|....|.|:|:..|: |...:|...:||             :| 
Human  3090 AFGASLFVPPSHVRFV--FPEPTADVNYIVMLTCAVCLVTYMVMAAILH-------------KLD 3139

  Fly  1350 QCDASVGKS----DQSFVSGSEILLVIVTGGQEFAGTTSNVKFYLKSPHRQQTSYQITQDPGHPK 1410
            |.|||.|::    .|......|||  :.||....:|||::|...|         |.:....||..
Human  3140 QLDASRGRAIPFCGQRGRFKYEIL--VKTGWGRGSGTTAHVGIML---------YGVDSRSGHRH 3193

  Fly  1411 L------LRNS--TIKIMVPR--GHIYIPTRLALRLVPNGRYPSWYCRSITVVDLKLKVQQLFLV 1465
            |      .|||  ..:|..|.  |.::   ::.:.....|..|:|:.:.:.|.||:......|||
Human  3194 LDGDRAFHRNSLDIFRIATPHSLGSVW---KIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLV 3255

  Fly  1466 ESWI------EGG---------SHIQFMRSKYFTYGNYSR--YPKYTW 1496
            ..|:      .||         |....:|.:........|  :.|:.|
Human  3256 NDWLSVETEANGGLVEKEVLAASDAALLRFRRLLVAELQRGFFDKHIW 3303

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42685NP_609717.5 REJ 411..753 CDD:307914 77/395 (19%)
PLAT 1367..1480 CDD:238061 33/137 (24%)
PKD1XP_024306066.1 LRR <50..>126 CDD:227223
leucine-rich repeat 70..92 CDD:275378
leucine-rich repeat 93..116 CDD:275378
PCC 97..2768 CDD:188093 152/798 (19%)
leucine-rich repeat 117..129 CDD:275378
GPS 3051..3100 CDD:197639 10/58 (17%)
PLAT_polycystin 3158..3277 CDD:238850 32/132 (24%)
PKD_channel 3751..4153 CDD:332708
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 52 1.000 Domainoid score I11438
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1276906at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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