DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42685 and pkd1l2a

DIOPT Version :9

Sequence 1:	NP_609717.5	Gene:	CG42685 / 34854	FlyBaseID:	FBgn0261571	Length:	1609	Species:	Drosophila melanogaster
Sequence 2:	XP_017212723.2	Gene:	pkd1l2a / 497373	ZFINID:	ZDB-GENE-050208-89	Length:	2484	Species:	Danio rerio

Alignment Length:	1578	Identity:	285/1578 - (18%)
Similarity:	512/1578 - (32%)	Gaps:	492/1578 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 FAVNLTVDTN---DYLIDEIHSDWKYTKNLRKLMRKWGIRSKRIVYNRCYFHRCTARFYNTKHKY 347
            |..|||...|   .::||....:     .:..::.|:.......|...|    .|:.::.|.||.
Zfish   287 FQGNLTCTLNAGDGHIIDNYSPE-----KMENVVHKYSHAGLYTVTVEC----STSDWHVTAHKT 342

  Fly   348 I----------------VAKVSSLNDRRKLLAHVVRFKIKVRKPPNVSC---------------- 380
            |                :::.::..:.:.|..|.::.::::....||:.
Zfish   343 ITIQEPLREFGTIKCHSMSQSTNSTNCKALYNHPLKIEVQLDAGTNVTYKVQHGSTDLASASAIR 407

  Fly   381 -LPALELEFCKNPEKPVYFSPMGHLEFFASISDACSTVEYDKITWQLCDITENKIIARLKNATGL 444
             :..:.:.|....::.:  .|..|.....::::..:..:...:  :||      ::.:|:..|..
Zfish   408 GMVPVNISFSSEAQQQL--GPGCHQLTVVALNEVTAAGQSSAL--ELC------LLEQLEGLTAE 462

  Fly   445 V----------VKLL----------PYKVHILNEPDRR-------------KVFLLRGKAVINGV 476
            |          |::|          |.::..|...|.:             :|||:....:...:
Zfish   463 VDLGPGLEQCPVRVLNISVSLSRGAPARLQFLLSGDNQSFSETHQMMHGGPQVFLISNTILTGKI 527

  Fly   477 TTVARCYMKYKPPPIEPLIKGN--------------------ERRLVDVRKPIIID------GSS 515
            ..|.:....:....::   .||                    ||........||.|      |::
Zfish   528 NVVVKAENSFSSMKVD---GGNTTVCRSETENQHDGKTTDEHEREARASHVQIIADPEVSVIGTT 589

  Fly   516 SKDRLKIR-ESIKSKQFLWTCISLDDPFNNYCKKYMSKS----PTLRLPPYALKENAVYDFSLTV 575
            |   :|:. :.:|....:|.|..     :..|.:.:.:|    ....|||       ||.||:..
Zfish   590 S---IKLYVKGLKDDNAVWKCTE-----SCRCSEDVIRSEIEISEACLPP-------VYAFSVYT 639

  Fly   576 ISRFDPRNRMTTTQTIKGVAKTTFTPQILCRRNCALGVYAPL---DSIHLISKCDDCPGTVKRYE 637
            :|    .|.....||  |:...|..|....|.:.|.....|:   :|:.|.::|:.|    ::..
Zfish   640 VS----TNANGFAQT--GMKCITVIPGDNLRLSIACSNCDPVNVDESVTLQAQCEGC----QKIV 694

  Fly   638 WWLLDTES-QPTLESSHKYLILHTLEPLVQIRLRVWVKGQGWADAFYTLRRNNGPQHGSCTIYPF 701
            |::..||. ..||...:..::   .:||.|::    .....:.....|||  ...|.....:|..
Zfish   695 WYIESTEEFNGTLGQCNSEML---KKPLTQMK----EDSSSFTIESKTLR--EAKQDIIVVVYGI 750

  Fly   702 L-GVEGFTMFEIDCPG-FESPFPPITYRY-MVSYGVVASNVPYSRIVLTLPAAETIM-------- 755
            . |:.|...:.|...| .|:..|...|.. .||....|..||.:..:|..|.:.||.
Zfish   751 KDGLSGSARYNISIHGSSETEKPSEAYTLTTVSPSHTAETVPVTLPILFRPPSCTISPHEGDVLS 815

  Fly   756 ---IS------ICDAIDMCV---------------EKRVEVKVLSIDKSMLTGQKEVMNYVPNFF 796
               ||      .|.| :.|:               |..||...|.:.......:..|:..|.|
Zfish   816 PFNISCSVDPAFCKA-EPCIFCFKTASGEHIYCGSEPTVESLYLPLGNEHSNYRLTVVVTVKN-- 877

  Fly   797 KRGHWNRAYIMGIAAITFIETSIDGDEFYSYLTGLVASTGSQMEQITTLSSHMLIRLHPVDFRGA 861
                     ..|:.|.|.:.|.:..           .||...::.:..|.|:.:..|........
Zfish   878 ---------TAGVTADTSVTTWVKD-----------TSTKPTVKDLQALVSNQVFHLQQQGRLTG 922

  Fly   862 TVMAEMFSHLGDSFSAIVQEHEWLHREGYYSLTAMHMFFMSILGKKTESHSNAMCSL--HNPACM 924
            ..:|:||..:....:..:.|.:        :.|..:    .:..:..:|.|.|:.|:  .|||.:
Zfish   923 AALAQMFQSVSHRLNNALPEDQ--------NGTVKN----ELRNQMLQSLSTAISSIPPKNPAEV 975

  Fly   925 NLQIIDLEKPFVIKFDPLILVRINSWLMSTWFLYRCIYFLGVIA--TQRHHPYDDALTIHKSGIA 987
            .:.                                    ..|||  |.:.|...|...:..|.:.
Zfish   976 QMS------------------------------------ANVIAGLTTQGHELTDTTQLQASSLL 1004

  Fly   988 YQINVTEVT------ENTKDI-QVKT--IDHI-HVIKLSTKLLYELQRRLNHSSILLQIISQQNF 1042
            ..::.:.|:      |:::.| |..|  ||.: ::||:|:.                  .|:||
Zfish  1005 TNLSKSLVSLTHAGDESSEQILQASTPIIDAVSNIIKVSSS------------------TSKQN- 1050

  Fly  1043 HNIYWWYPDPFPSKTSVLIVHAYSPVQFFRSAKEFQLTNPLVYKTNITHFNDASFNQY---MTNN 1104
                         :.|..:::....||....|.:.....|:|..|::       |..|   ::::
Zfish  1051 -------------EISGHLLNTVGNVQSALLAGKKVNQEPIVLSTSV-------FGLYVNRISSD 1095

  Fly  1105 SIQNSTEVHIYSVMLNHKAMLAVRIVNCSELMYIKMRLHRWPTLG----------QIRQHACRIT 1159
            .:|..|    ::|..|..|..                  :.|:||          .:|..:..|.
Zfish  1096 GLQKQT----FNVQKNSSASF------------------KLPSLGSDVLSANEPVDVRMTSFDIN 1138

  Fly  1160 P-------------------DMQGKRIWIANSCERSPAYVAIHKPGEIRYKTEDKDQLS------ 1199
            |                   ::.|..|.:||..|....::...:..||.....:....|
Zfish  1139 PFSRCEGKQISGSVGSLSLTNINGSEISVANLTEEIEIFLPRTQVAEINQTLLELGNFSTVVINV 1203

  Fly  1200 -ARGRKKGNRTHDGSETPEVRQKADFIDYDNEDIVEE--VLP-------------LN-------- 1240
             |.......:.....||| ::....|.||.|:...|.  .||             ||
Zfish  1204 TAPNISLVIKLDPSEETP-LQLLLGFQDYPNDTNNEARIQLPQEGNSEEERYTWVLNPSEMAMEV 1267

  Fly  1241 --YSILLE-------------IY------QCNIWKNRSLDPGWSEDHC-----TTSFEHSRGSSV 1279
              |.:|:.             :|      .|..|.  .:...||.:.|     ||:.      ..
Zfish  1268 GVYYLLVRPIVGAGVNSTSALVYITTIAADCLYWD--EIKANWSGEGCRVGPRTTTL------VT 1324

  Fly  1280 QCTCHTLGALSSRIFPISSQLFVEHIPVPIFTF--NMILMIFFALLFL--LLVFKFLLHLNIISA 1340
            ||.|..|....|..|.:.:.:.|........||  |.:::.|...:.|  |||        :|.|
Zfish  1325 QCLCTHLTFFGSSFFVMPNVVDVSRTAELFATFVNNPVVVCFVGAIILAYLLV--------VIWA 1381

  Fly  1341 YLKNPEFRLQCDASVGKSDQSFVSGSEILLVIVTGGQEFAGTTSNVKFYLKSPHRQQTSYQITQD 1405
            ..|:.:..::...:| ..|...::....||.|.||.:..|.|:|.|...|:....:...:.:| |
Zfish  1382 RRKDIQDAVKVKVTV-LEDNDPLAEYRYLLSINTGQRRGASTSSQVTVTLQGSEGESEPHHLT-D 1444

  Fly  1406 PGHPKLLRNSTIKIMVPRGHIYIPTRL----ALRL--VPNGRYPSWYCRSITVVDLKLKVQQLFL 1464
            |..|...|......:     :..|..|    ::||  ..:|.||:||...:||.||:...:..||
Zfish  1445 PEKPVFERGGLDLFL-----LTTPFSLGELQSIRLWHDNSGYYPAWYVNKVTVQDLENGQKWHFL 1504

  Fly  1465 VESW--IEGGSHIQFMRSKYF---TYGNYSRYPKYTWCKRFRS-RAEQLYFSWYLINAITGPSQS 1523
            ..||  |:.|   :....|.|   |..:..|:....:.|..:. |...::||     .|:.|..|
Zfish  1505 CNSWLSIDLG---ECTLDKVFPVATEMDLKRFSNLFFAKTAKDFRDGHIWFS-----VISRPPSS 1561

  Fly  1524 KVGGIIMNQFERTCVWICKTAITLAFVTLYFGKHTVSSIQEETRENVDNSLKVHLV---VMLGFF 1585
            .     ..:.:|..........|:....:::|      |..:..|...:..|:...   ||:|..
Zfish  1562 N-----FTRVQRVSCCFSLLLCTMLTSIMFWG------IPSDPSEQTMDLGKIEFTWQQVMIGIQ 1615

  Fly  1586 AFLIGLAIHVLFEVIILR 1603
            :.:|...|::|. |.|.|
Zfish  1616 SSIIMFPINLLI-VSIFR 1632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..753	CDD:307914	77/412 (19%)
CG42685	NP_609717.5	PLAT	1367..1480	CDD:238061	34/120 (28%)
pkd1l2a	XP_017212723.2	CLECT	40..159	CDD:153057
		Gal_Lectin	174..258	CDD:307994
		PKD	275..346	CDD:214510	15/67 (22%)
		GPS	1298..1343	CDD:321989	13/52 (25%)
		PLAT_polycystin	1406..1525	CDD:238850	36/127 (28%)
		PKD_channel	2025..2437	CDD:332708
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010