DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42685 and brv2

DIOPT Version :9

Sequence 1:	NP_609717.5	Gene:	CG42685 / 34854	FlyBaseID:	FBgn0261571	Length:	1609	Species:	Drosophila melanogaster
Sequence 2:	NP_648970.2	Gene:	brv2 / 39932	FlyBaseID:	FBgn0036712	Length:	736	Species:	Drosophila melanogaster

Alignment Length:	757	Identity:	139/757 - (18%)
Similarity:	231/757 - (30%)	Gaps:	282/757 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   781 MLTGQKEVMNYV-PNFFKRGHW-NRAYIMGIAAITFIETSIDGDEFYSYL-TGLVASTGSQ---- 838
            |:..|::..||. .|..:|..| |.:...|::.:.||.      :.:||: ..||.:..:|
  Fly   142 MVVLQEDHTNYYNTNNMQRLFWDNTSVTFGLSQVYFIY------QVHSYMKITLVEAFYAQKTNG 200

  Fly   839 ------MEQITTLSSHMLIRLHPVDFRGATVMAEMFSHLG---DSFSAIVQEHEWLHREGYYSLT 894
                  |||...:....|.::.|||           .|:|   ..:.......||  |..|:.:.
  Fly   201 YEGWWAMEQWQKIGVVRLRQMRPVD-----------CHIGLGKPEWDKKTYAPEW--RLPYHRMH 252

  Fly   895 AMHMFFMSILGKKTESHSNAMCSLHNPACMNLQIIDLEKPFV-IKFDPLILVRINSWLMSTWFLY 958
            ....|:                          :|.|   ||| .:|:|..|   |..|::
  Fly   253 YTEKFW--------------------------RIYD---PFVPAEFEPSFL---NGLLLN----- 280

  Fly   959 RCIYFLGVIATQRHHPYDDALTIHKSGIAYQINVTEVTENTKDIQVKTIDHIHVIKLSTKLLYEL 1023
                            ||.        ..|.:|..||....            |:.:|||
  Fly   281 ----------------YDH--------YGYLLNYPEVAGYV------------VLMMSTK----- 304

  Fly  1024 QRRLNHSSILLQIISQQNFHNIYWWYPDPFPSKTSVLIVHAYSPVQFFRSAKEFQLTNPLVYKTN 1088
                      :..:.|..:...|.|    ....||.|.:                         :
  Fly   305 ----------INCLKQIEYLRDYSW----LDKNTSALFI-------------------------D 330

  Fly  1089 ITHFN-DASFNQYMTNNSIQNS------TEVHIYSV-MLNHKAMLAVRIVNCSELMY-----IKM 1140
            :|.:| ||:....:|.. ::||      ..||:.|| ||.:     |...:.|||:.     :.:
  Fly   331 LTMYNADANLFTLITLR-VENSPFGIQLPRVHVDSVSMLGN-----VETRSNSELLILFVYTVLV 389

  Fly  1141 RLHRWPTLGQIRQH--ACRITPDMQGKRIWIANSCERSPAYVAIHKPGEIRYKTEDKDQLSARGR 1203
            .|.......:|..|  |......|....|:|.|..                        |:....
  Fly   390 ILFARGVFTKIWHHPAAAHEAWTMVDLAIYILNVF------------------------LTVLAI 430

  Fly  1204 KKGNRTHDGSETPEVRQKADFIDYDNEDIVEEVLPLNYSILLEIYQCNIWK-----------NRS 1257
            .:...|....:..|...|..::|:.....:.::|.:....|:.|....:||           .::
  Fly   431 MRDIETDALLQIIETATKGQYLDFQRPLRLHQMLFIVKGFLVCITTLRLWKVLQFASVFQHFTQT 495

  Fly  1258 LDPGW-----------------------SEDHCTTSFEHSRGSSVQCTCHTLGALSSRIFPISSQ 1299
            |...|                       ...:....|.|...|.|.|..:::|
  Fly   496 LFSAWRAVASLGVIILVVLMAIGITLAVPNGNNAVVFSHMVQSVVTCMWYSMG------------ 548

  Fly  1300 LFVEHI-PVPIFTFNMIL--MIFFALLFLLLVFKFLLHLNIISAYLKNPEFRLQCDASVGKSDQS 1361
             |...| |...|....||  :::.||:|||.:....:..::|..|. |...|:..:    .|::|
  Fly   549 -FNGDIHPADFFHGGRILGILLYLALVFLLAIILMNVFASVIYDYF-NETSRILKE----HSNRS 607

  Fly  1362 FVSGSEILLVIVTGGQEFAGTTSNV-----KFYLKSPHRQQTSYQITQDPGHPKLLRNSTIKIMV 1421
            .::..|.|.|      |:|....:.     |.|....|....:.::       :|.|...||.
  Fly   608 SITFLEFLHV------EYADLFGDAFRCLRKTYESRGHTVAENVEL-------ELNRRELIKF-- 657

  Fly  1422 PRGHIYIPTRLALRLVPNGRYPSWYCRSITVVDLKLKVQQLF 1463
            .|..|..|..|...|:...:      ||   .|.:|:.::||
  Fly   658 KRDLIKSPQELKRALLTEEQ------RS---ADYRLRGEKLF 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..753	CDD:307914
CG42685	NP_609717.5	PLAT	1367..1480	CDD:238061	23/102 (23%)
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	105/606 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010