Protein Alignment CG42685 and PKD1L3

DIOPT Version :10

• Sequence 1: NP_609717.5
• Gene: CG42685 / 34854
• FlyBaseID: FBgn0261571
• Length: 1609
• Species: Drosophila melanogaster
• Sequence 2: NP_853514.1
• Gene: PKD1L3 / 342372
• HGNCID: 21716
• Length: 1732
• Species: Homo sapiens
• Alignment Length: 870
• Identity: 180/870 - (20%)
• Similarity: 316/870 - (36%)
• Gaps: 195/870 - (22%)

  Fly   823 EFYSYLTGLVASTGSQMEQITTLSSHMLIRLHPVDFRGATVMAEMFSHLGDSFSAIVQEHEWLHR 887
            :|.|.|:.:.:       |:|:.:|....:..||..:  ..|....:|.|.|.:......:   .
Human   205 QFPSVLSSITS-------QVTSAASEPSSQPLPVITQ--LTMPVSVTHAGQSLAETTSSPK---E 257

  Fly   888 EGY------YSLTAMHMFFMSILGKKTESHSNAMCSLH-----NPACMNLQIIDLEKPFVIKFDP 941
            ||:      |...::......::.:...:.|.|:..|.     ..||..||.:....|...|  |
Human   258 EGHPNTFTSYLQVSLQKASGQVIDEIAGNFSRAVHGLQALNKLQEACEFLQKLTALTPRFSK--P 320

  Fly   942 LILVRINSWLMSTWFLYRCIY----FLGVIATQRHHPYDDALTIHKSGIAYQINVTEVTENTKDI 1002
            ..:..|||.:..:..|.|..:    .||........|:.....:.|:|....:.....||..:||
Human   321 AQVNLINSLIYLSEELLRIPFQNNNSLGFKVPPTVCPFHSLNNVTKAGEGSWLESKRHTEPVEDI 385

  Fly  1003 -QVKTIDHIHVIKLSTKLLYELQRRLNHSSILLQ------IISQQNFHNIYWWYPDPFPSKTSVL 1060
             ::..::..::.:...:     |.:...||:.|.      ::|:||...:      |..|.|
Human   386 LEMSLVEFGNIGEAFLE-----QNQSPESSVTLTSANATLLLSRQNISTL------PLSSYT--- 436

  Fly  1061 IVHAYSPVQF-FRSA---KEFQLTNPLVYKTNITHFNDASFNQY--MTNNSIQNSTEVHIYSVML 1119
            :.|. :||:. |.||   ||....:|.|   |: .....:||.:  :.|.:|..|    |.||:|
Human   437 LGHP-APVRLGFPSALALKELLNKHPGV---NV-QITGLAFNPFKDLDNRNIVGS----IGSVLL 492

  Fly  1120 --NHKAMLAVRIVNCSELM-YIKMRLHRWPTLGQIRQHACRITPDMQG-KRIWIANSCERSPAYV 1180
              |.|.:....::...|:| :..:.|...||...:..|...||.::.. ::..|.:....||..:
Human   493 SANRKLLQVHDLMEDIEIMLWRNVSLETHPTSLNMSTHQLTITVNVTSLEKSLIVSIDPDSPLLM 557

  Fly  1181 AI-----HKPGEIRY---------KTEDKDQ-----LSARGRKKGNRTHDGSETPEVRQKADFID 1226
            .:     ::|....:         |...||:     |:....:.|..|:..:.....||:.
Human   558 TLYLGFQYQPNCTHFHLNITLPKDKVWQKDEEYTWVLNPEHLQHGIGTYYITAVLSERQEG---- 618

  Fly  1227 YDNEDIVEEVLPLNYSILLEIYQCNIWK--NRSLDPGWSEDHCTTSFEHSRGSSVQCTCHTLGAL 1289
                   .:..|...|::..:.||..|:  |::    ||...|... ..|.....||.|:.|...
Human   619 -------AQQTPSLVSVITAVTQCYYWEIHNQT----WSSAGCQVG-PQSTILRTQCLCNHLTFF 671

  Fly  1290 SSRIFPISSQLFVEHIPVPIFTFNMILMIF-----FALLFLLLVFKFLLHLNIISAYLKNPEFRL 1349
            :|..|.:...:.||.      |..:.|.:.     .:||..||.|..   :.::.|..|:
Human   672 ASDFFVVPRTVNVED------TIKLFLRVTNNPVGVSLLASLLGFYV---ITVVWARKKD----- 722

  Fly  1350 QCDASVGK----SDQSFVSGSEILLVIVTGGQEFAGTTSNVKFYLKSPHRQQTSYQITQDPGHPK 1410
            |.|....|    :|....:....|:.:.||.:..|.||:.|...|.....:...:.:. ||.
Human   723 QADMQKVKVTVLADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLC-DPQ--- 783

  Fly  1411 LLRNSTIKIMVPRG--HIYIPTRL-------ALRL--VPNGRYPSWYCRSITVVDLKLKVQQLFL 1464
                   |.:..||  .:::.|..       :|||  ..:|..||||...:.|.|:.:|.:..||
Human   784 -------KTVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFL 841

  Fly  1465 VESW--IEGGS------HIQFMRSKYFTYGNYSRYPKYTWCKRFRSRAEQLYFSWYLINAITGPS 1521
            ...|  ::.|.      .|...:.:.|::       ::.:......:..|.|. |..| |...|
Human   842 CNCWLAVDLGDCELDRVFIPVSKRELFSF-------RHLFSSMIVEKFTQDYL-WLSI-ATRHP- 896

  Fly  1522 QSKVGGIIMNQFER----TC---VWICKTAITLAFVTLYFGKHTVSSIQEETRENV----DNSLK 1575
                    .|||.|    :|   :.:|...|.:.|..:   ..|.:...|:.|...    :..:.
Human   897 --------WNQFTRVQRLSCCMTLLLCNMVINVMFWKI---NSTTAKRDEQMRPFAVAWSELLVS 950

  Fly  1576 VHLVVMLGFFAFLIGLAIHVLFEVI 1600
            :|..|:|    |.|.|.|..||.:|
Human   951 IHTAVIL----FPINLVIGRLFPLI 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..>728	CDD:366875
		PLAT	1367..1480	CDD:238061	30/131 (23%)
PKD1L3	NP_853514.1	CLECT	33..138	CDD:153057
		GPS	633..672	CDD:470616	12/43 (28%)
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	635..685		13/54 (24%)
		PLAT_polycystin	743..859	CDD:238850	29/126 (23%)
		PKD_channel	1467..1678	CDD:462341
		Channel pore-region	1613..1651