DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42685 and Pkdrej

DIOPT Version :9

Sequence 1:	NP_609717.5	Gene:	CG42685 / 34854	FlyBaseID:	FBgn0261571	Length:	1609	Species:	Drosophila melanogaster
Sequence 2:	NP_001128338.1	Gene:	Pkdrej / 300124	RGDID:	1306587	Length:	2121	Species:	Rattus norvegicus

Alignment Length:	1484	Identity:	279/1484 - (18%)
Similarity:	492/1484 - (33%)	Gaps:	524/1484 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   369 KIKVRKPPNVSCLPALELEFCKN-------PEKPV------YFSPMGHLEFFASISDACSTVEYD 420
            ||..||..|...:.:.:.|...|       |:..|      |||       .||::|   |.:::
  Rat   108 KIINRKDQNAPLILSRDQEVTLNVTIRWHCPDALVVRKTWLYFS-------VASVND---TPDWN 162

  Fly   421 KITWQLCDITENKIIARLKNATGLVVKLLPYKVHILNEPDRRKVFLLRGKAVINGVTTVARCYMK 485
            :.. ||..:...|:     :...:....|||.|::.|    ..:.|:|...|:..||.....|:.
  Rat   163 RPV-QLPHVQVTKV-----SFLHIPKYALPYGVYVFN----FTLSLVRWDPVLPTVTDSDIIYIW 217

  Fly   486 YKPPPIEPLIKGNERRLVDVRKPIIIDGSSSKDRLKIRESIKSKQ--FLWTCISLDDPFNNYCKK 548
            .|..|::.::.|..|..|.....:|::||.|.|.   ...|.::.  |.|.|.:  :| ..|...
  Rat   218 VKKRPLKAVLPGASRVTVRFSDALILNGSMSYDP---EADIPTEGLIFFWYCTT--NP-RYYSDN 276

  Fly   549 YM-------------------SKSPTLRLPPYALKENAVYDFSLTVISRFDPRNRMT----TTQT 590
            ||                   :..|.|.:|...|:.|.||.|.:.|    ..:||..    |...
  Rat   277 YMLVTNRDVCHPKQDSLDWPWAVGPVLTIPAETLRGNGVYYFRMVV----QKQNRTAFSDKTVHV 337

  Fly   591 IKGVAKTTFTPQILCRRNCALGVYAPLDSIHLISKCDDCPGTVKRYEWWLL---------DTESQ 646
            ::|:....   .|.|..||. ...|..|...|...|..| |:...|.|.:|         |...|
  Rat   338 LQGLQPKA---HISCIENCG-HTLAVSDRFSLFLNCSSC-GSRDFYSWSILSRMGKEVMFDWAGQ 397

  Fly   647 PTLESSHKYLILHTLEPLVQIRLRVWVK--GQGWADAFYTLRR----NNGPQHGSCTIYPFLGVE 705
            ........||.:........:..|.||.  .:.|:....|||.    |.|||.|.|.|.|..|:.
  Rat   398 AVTRRDGAYLSMKAFAFRDFLENRFWVSLILKSWSGVIMTLRHPVVINQGPQVGKCNIDPASGIS 462

  Fly   706 GFTMFEIDCPGFESPFPPITYRYMVSYGVVASNVPYSRIVLTLPAAETIMISICDAIDMCVEKRV 770
            ..|.|.:.|.||:....|:||:                          :::|..|:|.
  Rat   463 MVTKFAVACSGFKDKNLPLTYK--------------------------VIVSELDSIG------- 494

  Fly   771 EVKVLSIDKS-----MLTGQKEVMNYVPNFF-----KRGHWN-RAYIMGIAAITFIETSIDGDEF 824
              .:.|:|::     |..|.:..   .|.||     ...|:| |.|.                :.
  Rat   495 --DISSVDENTLGTIMYLGTQPT---TPAFFLPVGMATNHYNLRLYA----------------QV 538

  Fly   825 YSYLTGLVASTGSQMEQITTLSSHMLIRLHPVDFRGATVMAEMF--SHLGDSFSAIVQEHEWLHR 887
            |..|     .|.||:    ||.:  .::...|......|:.::.  :.|..|.|.::|:.:|| .
  Rat   539 YDSL-----GTFSQV----TLQA--TVKAPTVRDSSKNVVQQLLNVTQLNSSLSTLLQKQDWL-P 591

  Fly   888 EGY--YSLTAMH---MFFMSILGKKT--------ESHSNAMCSLHNPACMNLQII--------DL 931
            .||  |.:|::.   .:.:.:.|.:|        :|...||.:: :..|.::.:|        ||
  Rat   592 AGYLVYVVTSVFNNIKWELELQGDRTRVLEYLVNQSFMLAMRTM-DEICQSVMVITKLTQKALDL 655

  Fly   932 EKPFVIKFDPLILVRINSWLMSTWFLYRCIYFLGVIATQRHHPYDDALTIHKSGIAYQINVTEVT 996
            .:| ..:...|:|.:.|..|.:    |:         .:..|.:...:.|..:||...::
  Rat   656 SQP-TSEATTLLLRQANQALQA----YQ---------QENKHLHSQQIEILCTGILTSLS----- 701

  Fly   997 ENTKDIQVKTIDHIHVIKL------STKLLYELQR-----------------RLNHSSILLQIIS 1038
                          :::||      |..||:.:|.                 |.::.::.::.:.
  Rat   702 --------------NLLKLAKTYHTSETLLFIMQSLSDMILANMVPGSKTVLRTSNFNMYVEKVE 752

  Fly  1039 QQNFHNIY---------------------------------WWYPDPFPSKTSVLIVHAYSPVQF 1070
            ..|.|..:                                 .:..||||..|        .|...
  Rat   753 NWNVHQAFRNESRCSNCLRATLNTSTVPGLPAKAPVSVMFCKFVDDPFPWLT--------YPENI 809

  Fly  1071 FRSAKEFQLTNP-----------------LVYKT------NIT---HFNDASFNQYMTNNSIQNS 1109
            ......|::|..                 ||.|.      |:|   ....|.|:: ||...|...
  Rat   810 STDVVGFRMTGAADNGNAIEIAPDTAEVYLVRKDLTSSSFNLTVGPGIKSAGFSK-MTTGGISFE 873

  Fly  1110 TE--------VHIY-SVMLNHKAML--AVRIVNCSELMYIKMRLHRWPTLGQ---IRQHACRITP 1160
            .:        :||. :|.:..:|::  .::::. :.||.|.:..|..|.:.:   :....|.:
  Rat   874 VDGRGFGEVLIHIVTNVTVLFEALVYEGIQLIP-TNLMAIFLVPHDIPPIAKWSGLFDPNCSV-- 935

  Fly  1161 DMQGKRIWIANSCERSPAYVAIHKPGEIRYKTEDKDQLSARGRKKGNRTHDGS-ETPEVRQKADF 1224
             .:.:.:.::::..|:.|                            .|.|... ....|.|.:.|
  Rat   936 -KEARVVCLSSTLLRTIA----------------------------QRRHSFKYNISVVLQASRF 971

  Fly  1225 IDYDNEDIVEEVLPLNYSILLEIYQCNIWKNRSLDPGWSEDHCTTSFEHSRGSSVQCTCHTLGAL 1289
            :          ..|.|..:.:.::..:......:...|.:..|... |.:...::.|.|..  |.
  Rat   972 V----------FKPTNKLVRIALFMVHCLDMYGIQSDWGQSTCVLG-ERTTWKTIHCICRK--AR 1023

  Fly  1290 SSR---------IFPISSQLFVEHIPVPI---------FTFNMILMIFFALLFLLLVFKFL---- 1332
            .||         |..:::::.|  :|.|:         .|.|.:.::  |:|.:::|:..|
  Rat  1024 RSRRQLTYSYMHIHFVTAKVIV--VPNPVDLRLQVISNVTQNPVTLL--AVLCIMIVYVILASWA 1084

  Fly  1333 LHLNIISAYL--------KNPEFRLQCDASVGKSDQSFVSGSEILLVIVTGGQEFAGTTSNVKFY 1389
            ||.::|..||        .|..|...|                .|:.|.||.:..:||.:||...
  Rat  1085 LHRDVIDQYLHDNVVILTDNDPFDTIC----------------YLVTIFTGSRWGSGTKANVFIQ 1133

  Fly  1390 LKSPHRQQTSYQITQDPGHP---KLLRNSTIKIMVPRGHIYIPTRLALRLV--------PNGRYP 1443
            |........::.:|    ||   .|.|.|       |....:.|:..|..:        .:|:.|
  Rat  1134 LMGTEGTSDAHCLT----HPYFQTLYRGS-------RNTFLLTTKNDLGDIHSIHVWHDNSGKAP 1187

  Fly  1444 SWYCRSITVVDLKLKVQQLFLVESWIEGGSHIQFMRSKYFTYGNYSRYPKYTWCKRFRS---RAE 1505
            |||..       ::||:.||....|:       |:                  |:|:.|   ..|
  Rat  1188 SWYLS-------RVKVENLFSKRIWL-------FV------------------CRRWLSVDTTLE 1220

  Fly  1506 QLYFSWYLINAITGPSQS-------------KVG----------GIIMNQFERTCVWICKTAITL 1547
            :.:       .:|.|.:|             |:|          .|:...|.|.....|..|:.|
  Rat  1221 ETF-------PVTHPDESLKKTDFFMIDLNDKLGKNHMWFSIFTDIVPKPFNRLQRLSCCLAMLL 1278

  Fly  1548 AFVT---LYFGKHTVSSIQEETRENVDNSLKVHLV--VMLGFFAFLIGLAIHVL 1596
            :.:.   ::|..:...  |.|:|:.       |::  :::|..:.||...:.:|
  Rat  1279 SSLVCNIMFFNLNITK--QPESRQG-------HIIRSMVIGVESALITFPVQLL 1323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..753	CDD:307914	88/381 (23%)
CG42685	NP_609717.5	PLAT	1367..1480	CDD:238061	29/123 (24%)
Pkdrej	NP_001128338.1	REJ	132..598	CDD:280229	126/566 (22%)
		PLAT_polycystin	1111..1226	CDD:238850	34/180 (19%)
		PKD_channel	1616..2046	CDD:285288
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8695
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010