DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42685 and Pkd1l1

DIOPT Version :9

Sequence 1:	NP_609717.5	Gene:	CG42685 / 34854	FlyBaseID:	FBgn0261571	Length:	1609	Species:	Drosophila melanogaster
Sequence 2:	XP_038948500.1	Gene:	Pkd1l1 / 289796	RGDID:	1564724	Length:	2586	Species:	Rattus norvegicus

Alignment Length:	1732	Identity:	315/1732 - (18%)
Similarity:	532/1732 - (30%)	Gaps:	607/1732 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 VNTEISYGYENQTYENGIEGSKSQNGNVSFSLADFPLVDEYPIYNQSSTCINNS------STEYQ 219
            :|:...:..|:..:.|.:   ..|.|.|....  |..|..|.:...|.|.:.:|      :..|.
  Rat   232 MNSSSIHNNESLAFANSL---PQQEGTVVVHC--FSSVSSYNVSFMSQTRVGSSQAWSGVTVGYT 291

  Fly   220 NQTVNDY-NFAVPCLAPNVNGRTSSVKNQQLLGQKGPLKVYLFMNRNPVYGEEYSVFTTMPSLGK 283
            .|:|:.| |..|  .|.:.|....:|..:.:     ||:...:...||      .|.||..|:.:
  Rat   292 MQSVSVYTNGTV--FAADTNITFVAVTEETV-----PLEFTWYFGENP------PVTTTSRSIRR 343

  Fly   284 -------------------------------KNFAVNLTVDTNDYLID---------EIHSDWKY 308
                                           |....|..|.|...|::         ...:|..|
  Rat   344 RLSIPQWYRVMVKATSRMGSVVSEPHLIRVQKRILANRLVSTASALVNANVSFECRLNFGTDVAY 408

  Fly   309 TKNLRKLMRKWGIRSKRIVYNRCYFHRCTARFYNTKHKYIVAKVSSLNDRRKLLAHVVRFKIKVR 373
            ..|......:.|..|...||:|      ...|  |........:||...|:::.  :|:   :..
  Rat   409 LWNFGDGSIELGSSSSGHVYDR------EGEF--TVEVLAFNNISSATLRKQIF--IVQ---EPC 460

  Fly   374 KPPNVSCLPALELEFCKNPEKPVYFSPMGHLEFFASISDACSTVEYDKITWQLCDITENKI-IAR 437
            :||.|..:...:::..::  :|:............:||...|      .||.........: :..
  Rat   461 QPPPVKNMGPAKVQIWRS--QPLRLGVTFEAAIICNISQGLS------YTWSFVGAEATAVTLPA 517

  Fly   438 LKNATGLVVKLLPYKVHILNEPDRRKVFLLRGKAVIN----GVTTVARCYMKYKPPPIEPLIKGN 498
            ..|.....:.|..|.:...|.....|| .::|..|.:    ||...||.       |:..:.:|.
  Rat   518 AVNTHRQTIMLPSYTLECGNYTAVAKV-QIKGSMVYSNYCVGVEVRARA-------PVSVISEGT 574

  Fly   499 ERRLVDVRK-PIIIDGSSSKDRLKIRESIKSKQFLWTCISLDDP----FNNYCKKYM-SKSPTLR 557
            ...|..... .||:.||.|.|......:::   :.|||.:...|    |::.....| :::|.:.
  Rat   575 HIFLSKATSTSIILSGSQSYDPDNPGAALR---YHWTCTAASSPIWPCFDDSTSYQMDTQAPAIS 636

  Fly   558 LPPYALKENAVYDFSLTVISRFDPRNRMTTTQTIKGVAKTTF---TPQILCR---------RNCA 610
            .|...|.| ....|.:|:......||   ::|.:      ||   .|.:..|         |:.:
  Rat   637 FPAKWLSE-CCDQFLVTLTVSSSGRN---SSQAL------TFLSTRPDLAFRFIHVSWVNFRDIS 691

  Fly   611 LGVYAPLDSIHLISKCDDCPGTVK--RYEW--WLLDTESQPTLESSHKYLI-------------- 657
            :...   :.:.|.:.|:|| |.|.  .|.|  :|::...:..:|....|.|
  Rat   692 VNWN---EEVSLRAVCEDC-GDVSDLTYSWDLFLVNATEKNAVEGKSCYSILLIGKVHGPVAGSG 752

  Fly   658 ----------------------------------------------------------------- 657

  Rat   753 EPMEDYGSLSPAPSSLAEEALMMSDPEGSWPFPSSSTAFDGISANFQEAGSSLSAEESASYGDNL 817

  Fly   658 ----LHT--LEPLVQIRLRVWVK------------------------------GQ---------- 676
                |||  .:|.:.|.   |.|                              |:
  Rat   818 LGPFLHTGRAKPTLMID---WPKALVSRAVFHGYTTSGIMGPDVTIKPFSLSSGEMYVLQASVAS 879

  Fly   677 -----GWADAFYTLRRNNGPQHGSCTIYPFLGVEGFTMFEIDCPGFESPFPPITYRYMVSYGVVA 736
                 |.|..:.|:  |..||..||.:.|..|:|..|:|.|.|   .|..|...|.:....|..:
  Rat   880 KHVLLGKAQLYLTV--NQAPQDMSCQVRPHRGMEAHTIFSIFC---MSGKPDFHYEFRYRIGNAS 939

  Fly   737 SNVPY----SRIVLTLPAAET-----IMIS--ICDA----IDMCVEKRVEVKVL----------- 775
            |:..|    ::....|||.::     :::|  :.|.    :..|.   |||.||
  Rat   940 SHTLYRGQDTQYYFLLPAGDSSDSYKVIVSTEVTDGQGSKVQPCT---VEVTVLPRYHGNDCHDK 1001

  Fly   776 --------SIDKSMLTGQ-KEVMNYVPNFFKRGHWNRAYIMGIAAITFIE---TSIDGDEFYSYL 828
                    ::....|.|. .|:.||:           |.|.||.:..::|   ||..|.  :|.:
  Rat  1002 DLYNSTLENLSTLQLVGSYTEIRNYI-----------AMITGILSRLYVESRNTSSCGQ--WSQI 1053

  Fly   829 TGLVASTGSQM---EQITTLSS-HMLIRLHPVDFRGATVMAEMFSHLGDSFSA--------IVQE 881
            ..::..:..::   :|.|.:.| |:|..|.....:.:.:.||:.......|.|        :|.|
  Rat  1054 QDVLIFSACKVPYTDQETMMDSIHILRDLISFPNKLSLMSAELIYKYAQMFLAQGQVSRRLLVDE 1118

  Fly   882 H---EWL-------------HREGYY-----------------SLTAMHMFFMSI--LGKKTESH 911
            .   |::             .|:|||                 ||:..|...:|.  :..:|..|
  Rat  1119 KLRVEFILLISGVWEAAKEDVRDGYYLQKEGMKIVSDMLLACLSLSPKHQIHISTGQMEFQTLVH 1183

  Fly   912 SNAMCSLHNPACMNLQIIDLEKPFVIKFDPLILVRINSWLMSTWFLYRCIYFLGVIATQRHHPYD 976
            .:...|:.|                                           ||.|..  |.|.|
  Rat  1184 RSPQSSIQN-------------------------------------------LGFIRV--HLPND 1203

  Fly   977 DALTIHKSGIAYQINVTEVTENTKDIQVKTIDHIHVIKLS--TKLLYELQRRLNHSSILLQIISQ 1039
            .||  |                 ...|.:|....::.:|:  .|..|..::....   |..::|.
  Rat  1204 VAL--H-----------------SPTQEETQSPCYISQLTFFMKSPYSGEQAPGQ---LGGVMSP 1246

  Fly  1040 QNFHNIYWWYPDPFPSKTSVLIVHAYSPVQF-FRSAKEFQLTNPLVY-----KTNITHFNDASFN 1098
                   |.|  ...|:..:|.....:||.. |.........||.::     :.|:..|...|.|
  Rat  1247 -------WLY--SCKSRRPILRGRLETPVTIEFGEEDHLHKKNPAMFVLLRDEVNVHQFTGLSEN 1302

  Fly  1099 QYMTNNSIQNSTEVHIYSVMLNHKAMLAVRIVNCSELM----YIKMRLHRWPTLGQIRQHACRIT 1159
            .       |.|.::||.......:|...:.:|..||..    ::..:::.|
  Rat  1303 S-------QESLQIHIEFSKPVIRAFPIILLVRFSEKATPSDFLMKQVYFW-------------- 1346

  Fly  1160 PDMQGKRIWIANSCERSPAYVAIHKPGEIRYKTEDKDQLSARGRKKGNRTHDGSETPEVRQKADF 1224
             |.|..::::..:..|..      ..|.:.....|.|      ||..|:...|:
  Rat  1347 -DEQTVQMYVPAAPWRGA------NVGYLSLLDADYD------RKPPNKYLAGA----------- 1387

  Fly  1225 IDYDNEDIVEEVLPLNYSILLEIYQCNIWKNRSLDPGW-SEDHCT---TSFEHSRGSSVQCTCHT 1285
                          :||::..:..||..|....    | ||..|.   ||.|     .|.|:.|.
  Rat  1388 --------------VNYTVHFQWIQCVFWDKTE----WRSEGPCPQPGTSPE-----KVNCSYHR 1429

  Fly  1286 LGALS------SRIFPISS-QLFVEHIPVPIFTFNMILMIFFALLFLLLVFKFLL-HLNIISAYL 1342
            |...|      :..|.:|| ..|..|      ..|::..||  .:|.|:::.||: ..:.:..:.
  Rat  1430 LAPFSVLRRKLNATFQVSSVSEFQSH------PHNLLPSIF--SVFFLVLYGFLMSKSSCVDCHK 1486

  Fly  1343 KNPEFRLQCDASVGKSDQSFVSGSEILLVIV-TGGQEFAGTTSNVKFYLKSPHRQQTSYQITQD- 1405
            |.       |......::..:.|.::..|:: ||.:..|..||.|...|..    :..:..|::
  Rat  1487 KK-------DPGCIFLEEEALLGHQLYAVVIDTGFRSPARFTSKVFIVLCG----ENGHSETKEL 1540

  Fly  1406 --PGHPKLLRNSTIKIMVPRGHIYIP-TRLALRLVPNGRYPSWYCRSITVVDLKLKVQQLFLVES 1467
              |..|...|||....::...|...| .::.|....:|..|||:...:.|.:|.......|..:.
  Rat  1541 CCPEKPLFGRNSRHTFILSTPHQLGPLQKIRLWHDSSGLSPSWFISHVMVKELCSGQAWFFSAQC 1605

  Fly  1468 WI----EGG---------SH------------IQFMRSKYFTYGNYSRYPKYTWCKRFRSRAEQL 1507
            |:    .||         ||            .:::...:..:..||:.|...:....|......
  Rat  1606 WLAVSKRGGQVLGEFFCLSHGLSFWKLFYSKFTEYLEDFHIWFSLYSQPPSSNYLHTQRLAVSFC 1670

  Fly  1508 YFSWY--LINAITGPSQSKVGGIIMNQFERTCVWICKTAITL 1547
            ..|.|  |...:|      |||     .|:..:.:..|||||
  Rat  1671 LLSVYSCLTALVT------VGG-----HEQRPLGVGPTAITL 1701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..753	CDD:307914	89/502 (18%)
CG42685	NP_609717.5	PLAT	1367..1480	CDD:238061	29/142 (20%)
Pkd1l1	XP_038948500.1	PCC	<242..725	CDD:188093	105/546 (19%)
		GPS	1398..1436	CDD:413374	15/46 (33%)
		PLAT_polycystin	1504..1622	CDD:238850	27/121 (22%)
		PKD_channel	2063..2389	CDD:400395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I10909
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010