DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42685 and PRY

DIOPT Version :9

Sequence 1:	NP_609717.5	Gene:	CG42685 / 34854	FlyBaseID:	FBgn0261571	Length:	1609	Species:	Drosophila melanogaster
Sequence 2:	NP_001104126.3	Gene:	PRY / 26067055	FlyBaseID:	FBgn0267489	Length:	1247	Species:	Drosophila melanogaster

Alignment Length:	1440	Identity:	316/1440 - (21%)
Similarity:	562/1440 - (39%)	Gaps:	320/1440 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 VYLFMNRNPVYGEEYSVFTTMPSLGKKNFAVNLTVDTNDYLIDEIHSD---------WKYTKNLR 313
            :|:|.||...:|:. .|..|:.||.::.|...:::: ...|:|...::         |..|.||.
  Fly    21 LYVFTNRYHTFGKG-RVIITLHSLHQEWFTTKVSLN-GLILVDYFQTNSSERKEAFLWYRTSNLE 83

  Fly   314 KLMRKWGIRS-KRIVYNRCYFHRCTARFYNTKHKYIVAKVSSLNDRRKLLAHVVRFKIK--VRKP 375
            |.:..:|:.: .::.|:.||||.....|::.....::|.::|    ..|..:.|:.|..  |:..
  Fly    84 KTLAFFGVSTDMQMPYDECYFHASEVNFFSNGFFSVIALITS----DGLYGNEVQAKTYTFVKTN 144

  Fly   376 PNVSCLPALELEFCKNPEKPVYFSPMGHLEFFASISDACSTVEYDKITWQLCDITENKIIARLKN 440
            .:::|.|...:..|.:..:|:::                   |..|:
  Fly   145 LHITCEPTFYIPRCHDSSRPLHY-------------------ETSKV------------------ 172

  Fly   441 ATGLVVKLLPYKVHILNEPDRRKVFLLRGKAVINGVTTVARCYMKYKPPPIEPLIKGNERRLVDV 505
                                          .||..|.| ..|       |::..|
  Fly   173 ------------------------------VVIRAVFT-RHC-------PMDNFI---------- 189

  Fly   506 RKPIIIDGSSSKDRLKIRESIKSKQFLWTCISLDDPFNNYCKKYMSKSPTLRLPPYALKENAVYD 570
                                    |:.||.....|....:...|.:.:..: :|.|:...|....
  Fly   190 ------------------------QYYWTLHDSTDTGKLHNTAYSTGNRVI-IPAYSQPNNQTLR 229

  Fly   571 FSLTVISRFDPRNRMTTTQTIK-GVAKTTFTPQILCRRNCALGVYAPLDSIHLISKCDDCPGTVK 634
            ..|.:.|.|||....||.|:|. ..::......|.|..||....|.....|||..:|..|..  |
  Fly   230 VMLLIRSTFDPLRTATTKQSIVFSSSRQLINVNIACVSNCNGNKYTIQMPIHLKGQCLRCQN--K 292

  Fly   635 RYEWWLLDTESQPTLESSHKYLIL---HTLEPLVQIRLRV----------WVKGQGWADAFYTLR 686
            :...|:...|..| :|.:.|.||.   .|.:.|:.|.|.|          ...|..|.    .|.
  Fly   293 KISKWIWRVEGLP-VEGASKRLIFDVKETKKRLLGIHLNVEAVNRYNSKLTYYGTSWV----FLE 352

  Fly   687 RNNGPQHGSCTIYPFLGVEGFTMFEIDCPGFESPFPPITYRYMVSYGVVASNVPYSRIVLTLPAA 751
            :|.||....|||.|.:|....|.|.:.|...::.|.|:.|...|...:|........|.:.||..
  Fly   353 KNMGPADTMCTISPRVGNAHETQFLLHCNQSQARFKPLQYCIGVENFLVDECKSDEDIQVRLPPT 417

  Fly   752 ETIMISICDAIDMC--VEKRVEVKVLSIDKSMLTGQKEVMNYVPNFFKRGHWNRAYIM--GIA-- 810
            |.:::.|||...:|  |...|||:.|.:|.|..| .||.::...::|:...|.:|:::  .:|
  Fly   418 EHVVVMICDHFSVCDDVTVTVEVRRLEMDDSDNT-VKEALSLARHWFEYADWQKAFLLLYQVAKL 481

  Fly   811 ------AITFIETSIDGDEFYSYLTGLVASTGSQMEQITTLSSHMLIRLHPVDFRGATVMAEMFS 869
                  .:.||:|      .|.|    ...|..|:..:..|:..:::.|.|:|.....|:|.|..
  Fly   482 IKSKERLLNFIDT------LYVY----EPQTTVQLAHLVRLTKRVVLSLEPLDDMEVNVVARMLQ 536

  Fly   870 HLGDSFSAIVQEHEWLHREGYYSLTAMHMF--FMSILGKKTESHSNAMCSLHNPACMNLQIID-- 930
            .:..:|..|:..:|.......|..|.::..  .::.|..:.|....:.|...:.:|:|   ||
  Fly   537 LISSTFRLIINSNELNTLMDIYYETMVNELCDILNKLNTEWEYIPKSQCRAESESCLN---IDNF 598

  Fly   931 ---LEKPFVIKFDPLILVRINSWLMSTWFLYRCIYFLGVIATQRHHPYDDALTIHKSGIAYQINV 992
               ||:..|::  |..|..||:||.:.|.|..|::::|:...:|.||.:....|.:|..:.::..
  Fly   599 RNRLEQMSVLR--PQGLEHINNWLHAHWKLSSCLFYMGMGTARRLHPEEGPKLIERSTFSMRMES 661

  Fly   993 TEVTENTKDIQVKTIDHIHVIKLSTKLLYELQRRLNHSSILLQIISQQNFHNIYWWYPDPFPSKT 1057
            .::.:: ::::.::.|.:|.:..:.|||.||:|||....:|:.|.|.:  .:.|||||:. .|.|
  Fly   662 FDLDQD-RNLEFQSADSMHTLIFTDKLLDELKRRLRTDEVLISIRSHK--QSQYWWYPEQ-ESHT 722

  Fly  1058 SVLIVHAYSPVQFFRSAKEFQLTNPLVY----KTNITH-----------------FNDASFN-QY 1100
            .||:|:||:....::.::|  :..|..|    |.|::.                 |:|...: :.
  Fly   723 QVLVVNAYTINNIWKKSQE--VAEPFQYISKLKINLSEGDPINEPTRQISKRGIDFDDPEEDIEN 785

  Fly  1101 MTNNSIQNSTEVHIYSVMLNHKAMLAVRIVNCSELMYIKMRLHRWPTLGQIRQHA--CRITPD-M 1162
            :.::.:..|.||.:|...|...::|.|..........:.:|:...|.|.::.:.:  |.:... :
  Fly   786 VIHDCVYTSLEVRMYRTELYGHSVLGVTFTQADIDFCVLIRMTNIPKLNEMERDSSTCLVRAGVL 850

  Fly  1163 QGKRIWIANSCERS-PAYV-----AIHKPGEIRYKTEDKDQLSARGRKKGNRTHDGSETPEVRQK 1221
            :...:.:.|.||:| |.|:     .|.:|.                   .|..|.|:
  Fly   851 KQTTLLLRNRCEKSQPVYIYLRAANISEPW-------------------NNFFHSGA-------- 888

  Fly  1222 ADFIDYDNEDIVEEVLPLNYSILLEIYQCNIWKNRSLDPGWSEDHCTTSFEHSRGSSVQCTCHTL 1286
                              .::...:|..|.||.....:|.|....|......|....:.|.|:.:
  Fly   889 ------------------FFAFSTDIRSCRIWNYARPEPSWQNFACMPELNKSIHFGIHCRCNYI 935

  Fly  1287 GALSSRIFPISSQLFVE-----HIPVPIFTFN-MILMIFFALLFLLLVFKFLLHLNIISAYLKNP 1345
            ....:...||   :.|.     |:..||...: .|::.||:|...::::.|
  Fly   936 SDFDADGMPI---IAVPMNLKCHLERPIVGQSYQIIIFFFSLSSFVIIYIF-------------- 983

  Fly  1346 EFRLQCDASVGKSDQSF------VSG----SEILLVIVTGGQEFAGTTSNVKFYLKSPHRQQTSY 1400
             :.:|   ||...|:..      |.|    .:::|:...||:..|||::|:.|..|. ..|....
  Fly   984 -YSMQ---SVSDWDKKLYTELFPVGGKCYRGDLVLMCTFGGRYNAGTSANIIFAFKF-FNQTRDI 1043

  Fly  1401 QITQDPGHPKLLRNSTIKIMVPRGHIYIPTRLALRLVPNGRYPSWYCRSITVVDLKLKVQQLFLV 1465
            .:.|||......|||||.:.:...|..|||.:|:|...:|.||.::||::.|.||:....|||.:
  Fly  1044 IVYQDPVFRTFKRNSTISLRLQNKHFCIPTGIAMRHDNSGVYPHFFCRNVVVCDLQTNEGQLFSI 1108

  Fly  1466 ESWIEGGSHIQFMRSKYFTYGNYSRY----PKYTWCK-RFRSRAEQLYFSWYLINAITGPSQSKV 1525
            :.||:       ..:.|.|..::|..    .|:...| ||....|....:|||...|.||.:...
  Fly  1109 QQWIK-------CYTVYKTVTSFSLINTDDGKFHCGKLRFLHAMENFMGNWYLFQPIIGPWRFGT 1166

  Fly  1526 GGIIMNQFERTCVWICKTAITLAFVTLYFGKHTVSSIQEETRENVDNSLKVHLVVMLGFFAFLIG 1590
            ..:...::||:|::|.|..|.:.||.|:||:....:.....::..|    :.:|:.|.|..::..
  Fly  1167 ERLAFCKWERSCIFIGKLFIAITFVVLFFGRTEPMACDPSPKKYND----IDVVLRLCFSCYVAN 1227

  Fly  1591 LAIHVLFEVI 1600
            ..:....|.:
  Fly  1228 CIVQASLETV 1237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..753	CDD:307914	71/355 (20%)
CG42685	NP_609717.5	PLAT	1367..1480	CDD:238061	37/112 (33%)
PRY	NP_001104126.3	REJ	<189..452	CDD:280229	76/305 (25%)
PRY	NP_001104126.3	PLAT	1019..1111	CDD:294016	34/92 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468728
Domainoid	1	1.000	52	1.000	Domainoid score	I11438
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	1	1.000	-	-		FOG0016889
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940